Evolocumab and Fatigue: What Users Say (Page 4)

• Doc...
• July 30, 2021

Evolocumab for High Cholesterol "I’ve been taking Repatha for seven months, every two weeks, 140 mg. For the first three months, I had mild myalgia and fatigue; not severe enough to discontinue dosing. After that time period, I’ve experienced shortness of breath, severe myalgia, and joint pain. Additionally, my vision is periodically blurry, and I developed a UTI. Recently, I was simply walking, and my right knee popped, causing pain so severe weight-bearing was difficult to impossible. An MRI revealed a torn medial meniscus, sprains of the ACL and MCL, as well as bruising of the medial tibial area. I am scheduled for surgery in two weeks. Unfortunately, my left knee is painful in the same area. I have decided to discontinue this drug and will inform my cardiologist of my decision."

• Rai...
• April 18, 2022

Evolocumab for High Cholesterol "Been on all the statins. My body is unable to tolerate them. The worst being Lipitor. It is a horror drug and was a current affair program in Australia some years ago. Unfortunately, my diet has a limited impact. Triple bypass and three stents further down the track, I felt doomed. Then my new cardiologist suggested this Repatha. Great! And it worked wonders for me, and there appeared to be no side effects other than a nose drip when I did physical stuff. Been on it for approximately three or so years, and it helped keep my cholesterol in check. But in the last six or so months, I have been feeling more fatigue, plagued with lightheadedness, a rubbery weak sensation in my legs, arms at times feeling weakish, along with a head fog. I now suspect it being Repatha. Been on a plant-based diet and now just try that on its own."

• Joh...
• Taken for 1 to 6 months
• June 12, 2025

Evolocumab for High Cholesterol "3 stents over a 15-year period, cholesterol being the cause. Has brought my bad cholesterol down, with an every-other-week dose. Do feel a bit more fatigued and not making weight loss progress. Going to request a reduction to once a month next doctor's visit."

• Pal...
• July 27, 2024

For High Cholesterol "After a profound ADR to statins with confirmed motor neuron disease, resolving after discontinuation, I managed chronically elevated cholesterol with diet, exercise, niacin, and Zetia; however, I was never able to reach the desired target levels for LDL and was started on Repatha 7 months ago. After two doses, I noted multiple low-grade but rather obvious constellation of symptoms, all listed on the Repatha drug information. None were debilitating at that time as they are presently. After a dramatic lowering of my LDL (160 to 50), I elected to stay on and see if the symptoms abated; however, they never did. A common thread in the patient reports herein, as well as in my experience, is the insidious nature of these symptoms, including easy muscle soreness/fatigue with activity, reduced athletic endurance, back pain, stiffness, general fatigue, and a general feeling of rapid aging and unwellness. I am due for my 8th injection next week and will not be taking any more, only hoping that I can recover to my baseline."

• Pal...
• July 27, 2024

For High Cholesterol "After a profound ADR to statins with confirmed motor neuron disease, resolving after discontinuation, I managed chronically elevated cholesterol with diet, exercise, niacin, and Zetia; however, I was never able to reach the desired target levels for LDL and was started on Repatha 7 months ago. After two doses, I noted multiple low-grade but rather obvious constellation of symptoms, all listed on the Repatha drug information. None were debilitating at that time as they are presently. After a dramatic lowering of my LDL (160 to 50), I elected to stay on and see if the symptoms abated; however, they never did. A common thread in the patient reports herein, as well as in my experience, is the insidious nature of these symptoms, including easy muscle soreness/fatigue with activity, reduced athletic endurance, back pain, stiffness, general fatigue, and a general feeling of rapid aging and unwellness. I am due for my 8th injection next week and will not be taking any more, only hoping that I can recover to my baseline."

• RSa...
• Taken for 6 months to 1 year
• February 13, 2021

Evolocumab for High Cholesterol "I am a 60-year-old male. Very fit and active. Family history of very high cholesterol led me to a triple bypass last year. Tried statins (all of them) for years with little reduction in my cholesterol. On Repatha now for almost a year. Worked beautifully to lower my cholesterol to almost nothing. Have some minor side effects I attribute to this medication (neck muscle tension pain, fatigue). But without it, my bypass plumbing would soon clog, and I would be a dead man. Of course, I will keep taking it. By the way, if it isn't obvious, this forum isn't scientific. Nobody should make a decision about whether to take this (or any) medication based on what they read here. The reason is, most respondents are here precisely because of their side effects. Thus, feedback from folks like me, who have had a generally positive experience, is fewer. Listen to your doctor."

• Ala...
• Taken for 6 months to 1 year
• February 5, 2021

Evolocumab for High Cholesterol "I just read some of these comments and cannot relate to them. I started on Repatha and my LDL went from high 90s to 24, and I was very happy. Other than old age pains and pains from statins, which I have been working with my doctor to reduce, it might be causing, it seems I am taking something different from what I have read in these comments. It does what was expected. It lowered my LDL and cholesterol. I am monitoring my fatigue, but I believe it is work-related and caused by my gym being closed for one year now. I have read scientific articles on the drug and have not come across these other comments. Age mid-70s."

• dog...
• Taken for 1 to 6 months
• January 11, 2016

Evolocumab for High Cholesterol, Familial Homozygous "Fatigue, headaches, muscle aches."

• DJW...
• Taken for 1 to 6 months
• March 12, 2025

Evolocumab for High Cholesterol "While this drug does what it is supposed to do, lower cholesterol, the side effects were unbearable. Back pain, shortness of breath, headache, muscle pain, severe fatigue."

• Car...
• Taken for 1 to 6 months
• June 20, 2019

Evolocumab for High Cholesterol "Three months on this drug and I lost all my energy and got chronic diarrhea. One year later and I still have the side effects. It has not been proven that this drug saves lives. BEWARE."

• Nei...
• Taken for 1 to 6 months
• January 16, 2019

Evolocumab for High Cholesterol, Familial Heterozygous "POISON. Flu syndrome immediately after one injection, followed by 8 months of muscle pain, cramps, and tightness, mostly in legs. Fatigue as well. No help from baclofen, diazepam, OTC pain meds."

• Jil...
• Taken for 1 to 2 years
• April 23, 2025

Evolocumab for High Cholesterol "Repatha lowered my cholesterol and kept it down. Side effects were bladder pain, multiple UTIs, and extreme fatigue."

• Lad...
• Taken for 1 to 6 months
• June 18, 2018

Evolocumab for High Cholesterol, Familial Heterozygous "Only took 12 doses and couldn’t move. Extreme fatigue and lethargy, back pain, and horrible leg cramps. Doctor has stopped for now."

• Rob...
• Taken for 1 to 6 months
• August 26, 2024

Evolocumab for Cardiovascular Risk Reduction "I am sleepy and fatigue easily. Could Repatha be a cause?"

• Mrs...
• Taken for less than 1 month
• May 8, 2023

Evolocumab for High Cholesterol, Familial Homozygous "I just had my first dose, 140 mg. I woke the next morning with a very swollen face and edema of my lower extremities and unusual fatigue. It’s the weekend. I will call my cardiologist on Monday."

• Way...
• Taken for 1 to 2 years
• April 19, 2023

Evolocumab for High Cholesterol "Random aching in shoulders and knees, blurred vision, low energy, lethargic."

• Ken...
• Taken for less than 1 month
• July 26, 2022

Evolocumab for High Cholesterol "After one week, fatigue, personality change, and loss of sex drive/libido! After the first week! Not sure if I will continue."

• Mik...
• Taken for 2 to 5 years
• June 28, 2025

Evolocumab for High Cholesterol, Familial Heterozygous "Extreme fatigue, some body aches, and muscle pains. Runny nose, sore throat, coughing, and sneezing."

• eil...
• Taken for less than 1 month
• June 2, 2025

Evolocumab for High Cholesterol, Familial Heterozygous "On my second injection, I did get a bruise, but soon went away. But on the 10th day of that injection, I started to feel cold/flu-like symptoms, dizziness, and fatigue."

• Ano...
• Taken for 1 to 6 months
• June 13, 2025

Evolocumab for Cardiovascular Risk Reduction "I feel fatigue after taking it. I also have lower back pain. The question below (on the effectiveness) is not applicable yet because I have not yet had a new cholesterol test."