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Vagifem and Pain: What Users Say

Pain: mentioned by 8 users (7.8%)

Based on user experiences from 102 Vagifem reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

burning 13.7%
headaches 10.8%
pain 7.8%
bloating 5.9%
irritation 5.9%
dizziness 4.9%
hair loss 4.9%
itching 4.9%
back pain 3.9%
vaginal issues 3.9%

Reviews for Vagifem

Commonly mentioned side effects
  • Lol...
  • Taken for 1 to 6 months
  • May 9, 2021

For Atrophic Vaginitis "I've been using Vagifem for a few months now & definitely took several weeks for my symptoms to calm down. Before using this, my entire vaginal area had become dry, hypersensitive & sore, and sex was so painful. Vagifem has restored lubrication & I feel like me again, so happy with results. Also, I have had no hot flashes since I started taking it & these were happening multiple times a night. I also have not had a UTI since & have been having them every couple of months most of my adult life."

10 / 10
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116 Report
  • Lol...
  • Taken for 1 to 6 months
  • May 9, 2021

For Atrophic Vaginitis "I've been using Vagifem for a few months now & definitely took several weeks for my symptoms to calm down. Before using this, my entire vaginal area had become dry, hypersensitive & sore, and sex was so painful. Vagifem has restored lubrication & I feel like me again, so happy with results. Also, I have had no hot flashes since I started taking it & these were happening multiple times a night. I also have not had a UTI since & have been having them every couple of months most of my adult life."

10 / 10
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116 Report
  • Bil...
  • Taken for 1 to 6 months
  • January 9, 2023

For Atrophic Vaginitis "I was prescribed Vagifem vaginal inserts as I have severe vaginal atrophy. This medication is extremely painful to insert 8-10 cm into the vagina of a woman who has a dry and shrunken vagina, even if copious quantities of lubricant are used. It has had absolutely no positive effects on my symptoms, and I am still getting up to pee several times a night. What a disappointing waste of money."

1 / 10
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14 Report

See also:

Frequently asked questions

  • Ang...
  • Taken for less than 1 month
  • July 27, 2022

For Atrophic Urethritis "47 years old. Prescribed by gynecologist. 1 month of being in a nightmare. Severe vaginal swelling, itchiness, burning, pain, and thrush-like symptoms without discharge but severe pain. My vagina since taking this medication feels like an overripe, rotten, juicy tomato. I also have severe water retention and swelling in my lower body. Just waiting until it's out of my system."

1 / 10
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12 Report
  • Anonymous
  • March 4, 2021

For Atrophic Vaginitis "Please say that Vagifem works? My vagina is so sore, and it throbs like mad! Plus, I feel terrible. I’m on antibiotics at the moment. I hope when the antibiotics finish, that I feel better. I hope all you girls don’t get these burning throbs! Soooooo bad, please help."

2 / 10
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10 Report

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  • Jul...
  • Taken for 1 to 6 months
  • October 27, 2021

For Atrophic Vaginitis "Prescribed this for vaginal atrophy and UTIs related to sex. After much hesitation, I tried this, and within a week, the vaginal irritation after sex stopped. A miracle, however, I did start to get pelvic pain, and after 8 weeks, started with irritation in my urethra. I'm taking a break from it."

7 / 10
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5 Report
  • Mum...
  • Taken for less than 1 month
  • March 15, 2025

For Atrophic Vaginitis "I was prescribed Vagifem after a failed smear test. The nurse couldn’t perform the smear test because she said I was very inflamed. It did hurt, so I wanted her to stop. I had no symptoms of VA until she tried to insert the speculum. I was prescribed 2 weeks of Vagifem and told to return on the 3rd week. The first week was grand, all went to plan. Insertion was fine until the first day of week 2, and oh my God, I just couldn’t get the applicator to insert fully. It was like it was hitting a brick wall, the pain was horrible. So I phoned the nurse who said that was normal and not to force it, just insert as far as possible and release the tablet. But the pain when I click the button was like I was letting off a bullet into my vagina. I could feel the tablet fire out and a sharp pain, but then the pain goes away fast. But I have lots of blood. The thought of having to do it puts me off using Vagifem. I’m not sure what’s causing the applicator to not fully insert until I see the nurse again."

5 / 10
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0 Report
  • Joy...
  • February 19, 2016

For Atrophic Urethritis "Awful leg pain, vaginal burning like on fire, back pain, pounding heart, dry cough, stomach pain, and diarrhea"

1 / 10
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78 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.