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How long does it take for Vagifem to dissolve?

Medically reviewed by Carmen Pope, BPharm. Last updated on Nov 7, 2022.

Official answer


It takes several hours for a Vagifem insert to fully dissolve, sometimes over 24 hours, and you may find that when you insert a Vagifem the next day, the applicator comes out covered with a sticky gluey substance – this is the previous days dissolving insert which you have touched with the applicator.

This is perfectly normal and Vagifem has been designed to release slowly.

  • Vagifem. Estradiol Vaginal Inserts.

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