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User Reviews for Diclofenac/misoprostol

Also known as: Arthrotec

The following information is NOT intended to endorse any particular medication. While these reviews might be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare practitioners.

Condition Avg. Rating Reviews Compare
Osteoarthritis 8.2
31 reviews 352 medications
Rheumatoid Arthritis 8.1
11 reviews 360 medications
Sciatica 9.0
9 reviews 281 medications
Summary of Diclofenac/misoprostol reviews 8.3 51 reviews

Reviews may be moderated or edited before publication to correct grammar and spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest in the medication will not be published. As reviews and ratings are subjective and self-reported, this information should not be used as the basis for any statistical analysis or scientific studies.

Reviews for Diclofenac/misoprostol

Robbear · Taken for 10 years or more July 30, 2020

Arthrotec (diclofenac / misoprostol) for Osteoarthritis: “I have had problems with my back for decades. Now, at 73, the challenges are worse. The family doctor says my whole back is degenerating (arthritis and compressed discs primarily). I have used Arthrotec in the past (at 50 mg. or 75 mg.). I got away from it when I developed chronic kidney disease. My family doctor has me on Tylenol Arthritis (the maximum amount I can take). I've been taking that for a while, but now I'm getting breakthrough pain. My kidney specialist said Arthrotec would be ideal for breakthrough, but no more than one tablet a day. It all works. I am very happy with the results.”

9 / 10
DR · Taken for 10 years or more October 29, 2019

Arthrotec (diclofenac / misoprostol) for Osteoarthritis: “I have been on Arthrotec 50mg three times daily for 25 years. I have never experienced any of the negative symptoms some other reviewers have mentioned. I have severe osteoarthritis. It is especially severe in my spine. As a result I have had numerous surgeries, fusions etc. each time before and following surgery I am told to stop taking Arthrotec for an extended time. Two weeks ago I had cervical spine surgery, so no arthrotec. Today I can hardly walk up and down stairs or get out of a chair! I am 77 yrs old and in good health. I weigh only 117 so it is not my weight that is holding me back. For me Arthrotec is a firm 10!”

10 / 10
Another fan of Arthrotec June 20, 2019

For Osteoarthritis: “I couldn’t take Celebrex for more than 3 days in a row because it would cause stomach pain, but I had found relief from arthritis pain only if I took the recommended dose. One day, my orthopedic doctor gave me samples of Arthrotec 75 to last until a new re-supply of Celebrex came in through my mail order pharmacy. With the very first Arthrotec, I got complete relief from my arthritis aches and pains. As a result, I decided to wait until my pain came back before taking another. I was able to wait several days before needing another (I’m patient with pain as long as I can function without medication), and I found that I got complete relief with each tablet. I never take 2 a day, and I never have to take them 2 days in a row. I never went back to Celebrex, incidentally. I recommend taking Arthrotec only as needed due to the risks involved with ANY medication. I can honestly recommend it to anyone except a high-risk patient. The effects are dramatic.”

10 / 10
Ashleigh · Taken for 1 to 2 years February 3, 2019

Arthrotec (diclofenac / misoprostol) for Rheumatoid Arthritis: “Two 50 mg daily. Usually knocks the pain level back to manageable. Without it I would be miserable with a poor quality of life . Generic did not work for me.”

9 / 10
Thriftyboy · Taken for 2 to 5 years July 11, 2018

Arthrotec (diclofenac / misoprostol) for Rheumatoid Arthritis: “I have been diagnosed with RA and X-rays also show degenerated disk disease. I usually take Celebrex, but when my back flares up I go to the one and only Arthrotec 50 mg / twice a day. I can actually get back on the treadmill again. The only medication that loosens up my back. A wonder drug!”

10 / 10
11Q11 May 26, 2018

Arthrotec (diclofenac / misoprostol) for Rheumatoid Arthritis: “Suffering from RA, Osteo, Fibro, and Sjogrens. Diagnosed at 41, am now 53. On Enbrel and Arthrotec75. This combination works very well for me, I still have pain but it is manageable. I tried to do generic arthrotec but it did not work. I usually take one tab before bed. If I am going to be very active, I will take one on the morning as well, but that is rare. The gas and stomach upset is expected along with feeling very hungry, and I do have bathroom issues from it. I have lost weight while taking this. I believe a lot of inflammation stems from the digestive track and when it is emptied I suffer a lot less. I will watch my kidneys, but as for this med I love it and the pros outweigh the cons.”

10 / 10
Laura · Taken for less than 1 month April 8, 2018

Arthrotec (diclofenac / misoprostol) for Osteoarthritis: “After taking two 50mg doses am and pm I am having to sit up in bed hoping that the gas and stomach upset will pass so I can get some sleep. I did notice some pain relief but I won't take it again due to the stomach upset.”

3 / 10
FLAP · Taken for 2 to 5 years March 1, 2018

Arthrotec (diclofenac / misoprostol) for Osteoarthritis: “I have Multiple sclerosis (MS) AND severe arthritis. The pain of arthritis is difficult sometimes to define from the other pain effects. If I fall, which is often, that pain is much worse. Lately, I was stupid so I increased the Arthrotec, after having frequent falls and finding the pain too much. Because of the higher dose, now I have edema (swelling) in my legs, and feet. I must start weaning back to a lesser dose since edema may not be likely, but it IS listed as a possibility. Even with my MS, I never had edema. I have to wing it from here. I'd rather have pain from ages-present arthritis, than edema because I stupidly thought a rather low dose would be a good thing to increase without considering the cost of really bad side effects. Lesson to take away: leave the dosing to your doctor and don't play at being a know-it-all because that never, ever works.”

6 / 10
06Honda · Taken for 1 to 6 months October 22, 2017

For Sciatica: “After taking 50 mg twice a day for a few months the pain started coming back. I talked to my doctor and we are currently trying 75 mg twice per day. After about a month I have decided it may be time to slowly go off it as it is not really doing a whole lot to relieve my lower right buttock pain that radiates down my leg/hamstring/calf and into one side of my foot. Only other med on file from the surgeon who did my L5-L6 operation a few years ago is Lyrica. The side effects that they show on TV are quite numerous but I may have not other option but to try it.”

LailaMay · Taken for 1 to 2 years August 28, 2017

For Osteoarthritis: “I have been taking this medication for well over a year now and I am totally satisfied. It has made my arthritis bearable. Even though my prescription allows me to take 2 a day, so far I have only taken 1 before bed time. I am nearly 76 years old. My husband who is 65 started taking the same medication but he takes at least 2 every day. He also has 2 slipped discs from a back injury along with the arthritis.”

10 / 10
Anonymous · Taken for less than 1 month July 5, 2017

For Sciatica: “Lower right hand back started acting up. So mornings are not great. I am taking Diclofenac/misoprostol 50mg/200mcg 2 pills a day. It has given back my quality life. I thought I would try just one in the evening, was a bad idea. take after a meal with a full glass of water np.”

10 / 10
06Honda June 2, 2017

Arthrotec (diclofenac / misoprostol) for Sciatica: “Started taking this medication about a week ago for Sciatica related pain, I had L5-L6 back surgery 10 years ago and get flare ups of pain from post surgery. It has helped the pain a fair bit, I still feel the right buttock pain when driving my car but other types of sittings is much better. The side effects are not so good, ablot of bloating. I feel like I have a balloon in my tummy; upset stomach; light headed and dizzy. With having vertigo in the past its hard to tell if is Vertigo or the medication. Doctor wanted me to try it for 2 weeks but will go see him today after 1 week and have a chat with him about it. My dosage is 2 pills per day with food 50MG. I will ask if taking 1 per day may be and idea and who knows it may be enough?”

7 / 10
SySa November 19, 2016

Arthrotec (diclofenac / misoprostol) for Osteoarthritis: “I have been on Arthrotec for 23 yrs now and can not recommend it for everyone but for me it was a life saver. I have RA and went threw many back surgeries (7) to repair degenerated disks. For a year I was in a wheel chair unable to walk and never left the house. MANY doctors told me that I had to resolve myself to living a life of a person who only has limited mobility. My intern a young man right out of med school recommended this. In the last 23 years I have lived a full and VERY active life and could keep up with a 35yr old (im 77 now). It saved my life , I could not live without it, I am active, travel, have sex and do anything I could (almost) when I was 50. For me it is wonder drug...”

10 / 10
LailaMay September 30, 2016

For Osteoarthritis: “I am 75 years old and this drug is very effective to treat my arthritis pain.”

10 / 10
T. Zen September 3, 2016

For Osteoarthritis: “Very helpful with arthritis pain but side effects outweigh helpfulness. I noticed nausea, severe leg cramps, feeling uncomfortable after eating small amount of food, fast weight gain. The main reason I quit this medication was because I felt it was making my antidepressant medication (Effexor) way less effective.”

6 / 10
Thatsnotmyrealname July 3, 2016

Arthrotec (diclofenac / misoprostol) for Rheumatoid Arthritis: “This drug has put my mom into kidney failure as she was on it for several years. I strongly caution anyone using this for extended periods.”

1 / 10
MChel June 6, 2016

Arthrotec (diclofenac / misoprostol) for Rheumatoid Arthritis: “I have had RA for 6 yrs. Recently I changed Docs, and he suggested Arthrotec as it was discovered I have early onset OA as well, I needed something else besides Metho and Humira. Let me say, Arthrotec is AMAZING, I hadn't felt so good in years! I am 35 yrs old and I was able to play with my kids, run around which I haven't been able to do. All was great until I ended up in the ER. I thought I was having a heart attack. Luckily it was not but it was an Ulcer. At least I had a little time with my kids.”

5 / 10
Dave D17 October 1, 2015

Arthrotec (diclofenac / misoprostol) for Rheumatoid Arthritis: “I recently switched from Celebrex to Arthroc. Although my stomach has been very upset most days, the pain in my shoulders, hips and knee has been greatly reduced. Also, I have gained considerable mobility in the range of motion in my leg/knee.”

8 / 10
Valzy · Taken for less than 1 month September 30, 2015

For Osteoarthritis: “Tried several anti inflammatory drugs with 0 pain relief. I was ready to try cortisone shots in my painful crippling hips ( both ) til my Dr said let my try this last pill for you with Immediate pain relief!!! I cried & felt like giving my Dr a big tearful hug! Wow...what a difference. Taking 75”

10 / 10
painny · Taken for 1 to 6 months May 31, 2015

For Osteoarthritis: “I was taking Diclofenac-Mistrust 75-200 TB twice daily. It caused me to have gastritis so severe that I thought I would die. Had to stop taking it and begin another medication for my stomach. Don't like it at all”

1 / 10
cuddles1961 May 5, 2015

Arthrotec (diclofenac / misoprostol) for Sciatica: “I have suffered with sciatica for 3 years and now have pain in my right foot along the arch. I took this medication when I was first diagnosed and it did nothing to relieve the pain. I decided to give it another shot last week because of the foot pain and it started helping right away with both issues. The only problem I have is I am bloated and feel like I have gained 10lbs! This is a huge bummer since I am also on a weight loss plan! But I will keep taking it for now.”

9 / 10
Anonymous · Taken for less than 1 month August 3, 2014

For Osteoarthritis: “I was prescribed 50-0.2 mg twice a day. This medicine did work to relieve my back pain, but it came at a cost. It caused me to have severe stomach cramps and constantly feel nauseous. I had to stop taking the medicine because of this problem.”

6 / 10
soozilla · Taken for 5 to 10 years November 8, 2013

For Osteoarthritis: “Prescibed two arthrotec 75 daily plus two tramadol due to osteoarthritis in both knees had to drop to one arthrotec taken in the morning due to reflux and vomit during night.Feel hunger constantly even when fed.Weight hard to manage and can still feel sick and dizzy with a burbling stomach for hours after taking arthrotec”

4 / 10
not sure what to do · Taken for 10 years or more July 7, 2013

Arthrotec (diclofenac / misoprostol) for Osteoarthritis: “I have been taking Arthrotec for 25 years and gradually have had to increase to get the same relief. I was taking 75 mg two times a day. My concern at this time is that my Kidneys have been slowly deteriorating over time and I did not even notice it until my doctor called me yesterday after some blood work and asked me to stop taking it. I am having blood work again Monday and I already know that my Kidneys are working better. It is a tough call because the pain is coming back full force. I also have Fibromyalgia and type 2 diabetes and other issues. I wish there was a way to find relief from pain without medicines and if you had asked me a week ago I would have told you that I would be hooked on Arthrotec and could not imagine life without it.”

8 / 10
Rita011 June 26, 2013

Arthrotec (diclofenac / misoprostol): “I have been taking Arthrotec for two days now. I feel a lot better. Today I can walk, stand up and sit. The only problem is it makes me feel hungry all day. Its like I haven't eaten even though I did 10 minutes ago.”

8 / 10