User Reviews for Pristiq
The following information is NOT intended to endorse drugs or recommend therapy. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners in patient care.
Learn more about Pristiq.
Reviews for Pristiq to treat Depression
"After five antidepressants this is the one that brought me back to myself. I'm not 100%, but I was at 40% and now 80% myself. I am able to laugh again, appreciate the beauty of the out doors, and to enjoy my kids without yelling due to being constantly overwhelmed. My insurance switched me to generic pristiq and within a month I started feeling the anxiety and depression return. I was back to feeling like a zombie and in addition had withdraw symptoms from stopping the name brand pristiq including headaches, fatigue, muscle aches, and insomnia. I have switched back to name brand 4 days ago and feel a tiny bit better, but praying name brand pristiq kicks back in quicker. No generic!"
Plutohomer (taken for 2 to 5 years) July 3, 2017
15 users found this comment helpful.
"Originally I would have given this drug 10/10. I had anxiety so bad that at one point I could not even leave the house without having a panic attack. On Pristiq, from my experience, a few wonderful things will happen: 1. You couldn't have a panic attack if you tried to talk yourself into it. 2. You will not gain weight (I lost weight originally and then went back to normal after 6 months). 3. Your depression will subside - though there is a BUT with that. The not great: 1. It is really hard to get off of, brain zaps, no step down options. 2. You become a bit zombie-like, lost creativity etc. A lot of not caring so much. 3. Sexual side-effects, though they do improve over time. Solid 5/10"
beesy24 (taken for 2 to 5 years) June 21, 2017
9 users found this comment helpful.
"I took one dose and ended up in the ER with a horrible pounding, predominately right sided migraine. Along with about 6 hours of vomiting. It had to have been the worst migraine of my life."
xixi (taken for less than 1 month) June 15, 2017
5 users found this comment helpful.
"I've been on 100mg Pristiq for 6 years for panic and depression. Prior, I had been on 150mg Effexor XR for 7 years. For panic, this drug is excellent. If you've experienced "brain shivers" or "shocks" when missing a dose on other medications, this one has managed to remove them, which I feel is great. I want to note, that you will get withdrawal headaches every so often on Pristiq which can be slept off. Over the years, I found that I had a more stable experience when taking my 100mg dose at intervals of 50mg at breakfast and the other 50mg at bedtime. This strategy attempts to keep your body with a consistent supply so you are "topped up" to minimize the withdrawl effects."
ExerciseToo June 7, 2017
13 users found this comment helpful.
"I have been on pretty much every antidepressant that is out there. Nothing has really helped and the few times I felt a slight improvement in my condition, the side effects outweighed the benefits. Pristiq has been totally different. Within a week of starting it I see a positive change. My overall mood is better, I have more energy, and I am more productive. Also, when my mood does take a dip, it seems that the "bottom" has been raised. In other words, the lows aren't as low as they once were. I have only been on it a couple of weeks and I am told that I still may not be experiencing the full benefit, which is great considering how much better I already feel. No side effects whatsoever. Very grateful for this medication."
Much Better (taken for less than 1 month) June 5, 2017
24 users found this comment helpful.
"I was on Celexa for 5 years before it stopped working. Took the DNA test and celexa and others were in red but pristiq was green. Pristiq I took for 2 months and it was the worst hell I've ever gone through. Ditched the DNA test as it's garbage and been on zoloft for 5 months with good results again"
Matt4567 (taken for 1 to 6 months) May 18, 2017
11 users found this comment helpful.
"I am almost 24 and have been on pristiq for about 5 weeks. I am now up to 100 mg but started at 50. I have no negative side effects besides maybe a light headache. I have been on over 10 anti-depressents in the past with nothing but bad side effects and had sworn them off 6 years ago. Nothing worked for my anxiety and depression in the past besides of course my take as needed klonopin. Pristig has been good. No side effects or appetite increase. I am also going through an extremely tough and stressful time in life at this point and once I was upped to 100 mg, I have noticed an increase in my mood positively. Like I said, I had sworn off meds for years, but I feel like this one may be working. Give it a try and work with your doctor"
Nat attack (taken for 1 to 6 months) April 29, 2017
27 users found this comment helpful.
"I tried Pristiq, which had been listed on my Genesight review in the positive column. Was on it for three weeks and had to stop as I had developed hypermania: no sleep, talkative, spending, messy, walking around confused and generally felt very high. Felt very unsafe driving and was also eating everything in sight until I had a stomach ache. Gained weight and just felt plain bloated. While I recognized that something was wrong, I was not thinking straight enough too judge. Fortunately, the prescriber recognized it and I am now stopped 3 days. Don't feel great, but I am glad I was not on it long enough to have withdrawal problems."
jmsagain April 29, 2017
16 users found this comment helpful.
"I'm taking Pristiq for the second time, I have experienced episodes of depression since 14 or 15 but always managed to come out eventually by my own means. When I was 28 I took Pristiq for the first time because I had a lot of anxiety and was depressed. My side effects were some mild headaches, feeling sleepy during the day, waking up during night. Now I'm 31 and was feeling very angry, anxious and depressed because a "professional failure". I'm on day 3 taking 50mg in the morning and my mood and anxiety are better already but feel sleepy during the day and wake up in the middle of the night feeling ready to go for a full day. "
I know I have potential but... (taken for less than 1 month) April 23, 2017
18 users found this comment helpful.
"I have BPD II, PTSD & anxiety with agoraphobia. I've tried a LOT of different meds & gone unmedicated as well, probably over the last 15 years or so. Right now, I'm on Lithium 900mg. Just stopped Gabapentin 900-1200mg. On Desvenlafaxine 100mg (start, 50mg) about 1 year - Since I started, I've been lifted out of a suicidal & debilitating depression. Take into consideration lithium, my moods are more levelled out and I don't feel like crying at the drop of a hat. I don't feel completely hopeless. However, I do feel unnecessarily agitated, sleep issues - too much or insomnia, low energy, incessant nausea. I've also gained an incredible amount of weight, without appetite. DNA test "Green-lit" Pristiqu... Going to see Dr. today."
S Dove April 13, 2017
9 users found this comment helpful.
"I recently took a DNA test which determines which best antidepressants that your most compatible with since I'm very extremely sensitive to meds and pristiq was listed in the green column that would give no side effects, yeah right after nearly giving this med a fair two months trial of hell being on this toxic chemical I've encountered practically all the severe side effects reported from worsening depression of feeling hopeless and being in a thick fog everyday that made it almost impossible to hold a conversation and more like a robot, depersonalization / derealization, blurred vision along with seeing distorted objects and shapes that makes me sensitive to light, mood swings, horrible word finding difficulties, this med ain't me!"
kevin572 (taken for 1 to 6 months) April 10, 2017
19 users found this comment helpful.
"Pristiq was great for me but seem to stop working after 5 years. Definitely start on the 25mg dose. Let your body get use to it, before increasing. I went to 50 mg but didn't like the side effects, so went back to 25 mg. Nothing else has worked as well, so I am thinking of giving Pristiq another try after trying numerous other drugs."
Ryskke10 (taken for 2 to 5 years) April 9, 2017
14 users found this comment helpful.
"Gained 30 pounds while on prednisone. It was my 5th medicine to try. I was skeptical but it actually worked. Pristiq made me so sleepy and in a constant state of lala land. Gained 30 pounds while on prednisone and Started pristiq at the same time. I have gone a year and a half and still haven't lost the weight. It's different for everyone, and weight gain isn't normal, apparently. I tapered off the 100mg almost a month ago and now I have so much energy! On the meds I was still depressed but was ok with it. off the meds, I'm attacking the issues head on and trying to make up for the last 1.5 year stupor. I'd just had enough of missing out on life. Good meds if you want to sleep thru life and just not have to think about issues anymore."
Blondie80 (taken for 1 to 2 years) March 30, 2017
17 users found this comment helpful.
"Started on 50mg now up to 100mg. The main side effect I am experiencing is tingling and numbness of the face, head and ears. The sensations vary location and intensity, usually peaking in the afternoon/evening 6-8 hours after ingestion. The overall effectiveness of the medication is unclear due to concurrent methamphetamine use, however I am feeling better than I was prior to commencing treatment."
Freakin (taken for less than 1 month) March 9, 2017
15 users found this comment helpful.
"I have been on Pristiq for at least six years for post-menopausal anxiety/depression. I tried several other medications without success, but this one is great. No side effects other than headache and mild nausea the first couple days. I feel "normal" 99% of the time - moods have evened out, almost no anxiety/irritability and have an overall happy feeling. I would take it in the morning, as it can cause mild insomnia. I will stay with this one."
waffles62 February 5, 2017
47 users found this comment helpful.
"My experience with this drug was definitely not positive. I was on 25mg for about 2 weeks and noticed little effect, so I increased to 50mg. About a week after increasing to the 50mg, I started having severe anxiety attacks for no reason. I am in college and I had to leave school because I couldn't handle it. It is so so horrible. This has continued for about a week now. I stopped taking it a few days ago and am still waiting for it to get out of my system because I feel so horrible. I am going back to my old drug, Zoloft, because I didn't have any issues."
Anonymous (taken for less than 1 month) February 2, 2017
10 users found this comment helpful.
"MY PCP prescribed pristiq for my depression, anxiety, mood issues etc. He told me that the drug takes a few weeks before you could see a difference but I feel like I experienced everything the first day I took the drug. Although my mood and energy improved and felt better overall the side effects were so severe I decided to discontinue after the first day. My side effects started with heart palpitations, sweating, dizziness and a faint feeling. This later subsided but turned into nausea and loss of appetite I couldn't eat anything that day and even water made me gag. That night I slept for a total of 3 hours I couldn't stay asleep and the time I did fall asleep it felt like I wasn't asleep at all. My body felt numb and my heart was racing."
SaraS19952009 (taken for less than 1 month) January 28, 2017
21 users found this comment helpful.
"Psychotropic medications are appropriate for the small percentage of us who would literally die by our own hands if we didn't take them. For that reason, their relative levels of effectiveness are often viewed by us through a completely different lens (realistically) than by those who take them for less serious reasons. Even bouts of major depression don't constitute a definite reason for taking pharmaceuticals. If it keeps you alive & lets you to work towards having something better BEYOND just 'existing', it's working. Try to reevaluate the manner in which YOU are evaluating the medication's effectiveness based upon what it is TRULY intended to do. As with everything in life, maintaining realistic goals & expectations is key to happiness."
Candles17 (taken for 1 to 6 months) January 27, 2017
73 users found this comment helpful.
"Pristiq changed my life for the good. I tried others, this was the only one that worked and worked wonders for me. The only downside was a weight gain first year or two which is now under control."
John1111 January 25, 2017
21 users found this comment helpful.
"For a few weeks I had a dry mouth. I still waken during the night but straight back to sleep again. At the beginning some brain zap things. But I love it! This medication makes me feel normal, happy, awake and life is much better. A little concerned about coming off it but I'll deal with that at the time."
NouraMcC January 19, 2017
31 users found this comment helpful.
"I've tried many different medications over the years, and Pristiq has been the only one that I can seem to tolerate. I started on sample packs at 50 mg for a few months, and it was actually working, until my doctor's office conveniently ran out. I was forced to go on Effexor, and though it may be a similar drug, it is absolutely NOT the same. I felt shaky, agitated, and suicidal thoughts also came back while on it. Now finally back on Pristiq, and after two days, my anxiety/depression is almost completely gone. It's like some sort of "switch" went off in my brain. I don't feel desperate and I'm not texting someone 20 thousand times per day because I feel so suicidal and needy. I am a trashy mess without this drug."
Sarah F. January 18, 2017
32 users found this comment helpful.
"Anyone who appreciates their physical health as much as their mental health I'm warning/begging you not to take Pristiq. It's intolerable in every way. I've been on it 4 weeks and 2 days. NO POSITIVE BENEFITS! However I have experienced the following from Pristiq: severe nausea, vomiting, nightmares, night sweats, headaches and migraines, brain zaps, loss of concentration , blurred vision.... If I can help only one person to not put this horrid dug into their body this comment will be worth it. Please, do yourself a favor, ther are other drugs out there. I regret every single day on Pristiq. I feel even more depressed than when I began."
Jessthebest (taken for 1 to 6 months) January 17, 2017
12 users found this comment helpful.
"It's an amazing drug. I have started having GAD due to the nature of my job, I had tried several meds and nothing worked for me. Pristiq made a huge difference in my life, where I felt alive again. For people afraid of withdrawal symptoms, I have weaned off Pristiq over a period of 2 months with no issues. Now after 2 months pristiq free , I am scheduling an appointment with my GP to go back on pristiq as stress levels has heightened again. The only side affect I had was lower sex drive which can be stressful, yet manageable. That's the only reason I have rated it 9"
Hassan1234 (taken for 6 months to 1 year) January 15, 2017
34 users found this comment helpful.
"I just want to share my experience with Pristiq I had suffered depression since I was 15 and tried many antidepressants that made me hallucinate, gain weight and sleep all day. The day since my doctor changed my medicine to Pristiq my life has changed for ever I can safely say that my depression is completely gone. It also diminished my anxiety by 90%. I have absolutely no side effects no weight gain, tiredness, dizziness. On the contrary, it gives me energy, and I feel happy and calm all the time. I am more social, and I laugh and live life like I used to. Pristiq saved my life, and I know that for some people it may not be the best but if you are trying to look for a new antidepressant you should definitely try Pristiq."
Jessica Sanchez January 13, 2017
85 users found this comment helpful.
"This med works well for norepinephrine uptake inhibition which is my problem. However, it can cause anorgasmia in men over 50 years of age. I can have an erection and sexual intercourse but I never finish the job. One of the side effects listed for this drug if you read the small print. I stopped using it years ago and still have side effects."
Senior M January 10, 2017
5 users found this comment helpful.
More about Pristiq (desvenlafaxine)
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- Drug class: serotonin-norepinephrine reuptake inhibitors
Other brands: Khedezla