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Wellbutrin XL User Reviews & Ratings (Page 4)

Wellbutrin XL has an average rating of 7.5 out of 10 from a total of 492 reviews on Drugs.com. 66% of reviewers reported a positive experience, while 16% reported a negative experience.

Reviews for Wellbutrin XL

Commonly mentioned side effects
  • Roc...
  • Taken for 1 to 6 months
  • December 8, 2022

For Depression "This medication saved me. I know it sounds dramatic and cliché, but it honestly did. After the first 2 days, I noticed a difference. Funny, I didn’t realize how depressed I was until the darkness started to lift, and I started feeling better. I was in so much pain mentally that I actually hurt physically, my body ached every morning. I was hurting so bad. I was tired all the time, I could hardly make it through the day, and I was in such a dark place I felt nothing could help me but death. It was that bad. I quit smoking and drinking, started exercising, and was shocked at how good I felt mentally. This might not work for you, I get that. There is no such thing as a miracle pill, we all have to give it a 100 percent too. It won’t work if you don’t work with it, it’s an aid, not a cure. Good luck to you all. Wishing you nothing but peace and happiness. It will get better. ❤️‍"

10 / 10
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  • Vic...
  • Taken for less than 1 month
  • December 8, 2014

For Major Depressive Disorder "It's only been four days - I've been told it takes about 2 to 3 weeks for full effect. I am taking 300 mg per day. I definitely feel better, but it's subtle at this point (I wanted to go outside and be part of society). What I'm most surprised about is the lack of side effects (other than no appetite). I have not one side effect."

8 / 10
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  • Bet...
  • Taken for 1 to 6 months
  • August 9, 2018

For Depression "I’m very wary of meds as I hate the idea of a band-aid for something that could be fixed in other ways... however, my depression got so bad I couldn’t stand myself anymore. I work in the mental health field so obviously I need to be well to help others. When nothing I tried was working and I was really beginning to lose hope, I finally gave in and tried Wellbutrin. I’ve had excellent results! Occasionally have weird dreams, but it’s nothing I can’t handle (I enjoy dreams!). My energy is back to normal, I’m able to enjoy the things I’d lost enthusiasm for! I’m hopeful again. I do want to note that I also work at doing a bit of exercise each day, eating healthy, sleeping better, and avoiding substances that harm me in any way. The meds also helped me reconnect with my spirituality! It’s truly been an amazing experience."

9 / 10
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Frequently asked questions

  • 14...
  • Taken for 1 to 6 months
  • January 22, 2015

For Major Depressive Disorder "The lowest dose made him stop saying he wanted to kill himself. The doctor upped his dosage, and I can see my son smile and laugh again. No side effects at all. He even dances now. He's so funny. Before, it was a nightmare with him. He's also on Latuda, but that takes 3 weeks to kick in. Wellbutrin XL is a lifesaver for major depression. No more ups and downs."

9 / 10
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  • Anonymous
  • Taken for 1 to 6 months
  • July 5, 2014

For Major Depressive Disorder "I was started on 100 mg of Wellbutrin in January. Initially, did not note much of a mood alteration other than feeling more energetic. I was upped to 200 mg, and I had never felt better in my entire life. I started performing great in school, had a high energy level and motivation. I was happy and felt good. I lost initially 5 pounds and now I lost a total of 20 in three months (note I also was attempting to lose weight). The only side effects I experienced were hot flashes the first week I took 200 mg, which was odd but manageable. Also, I had insanely vivid dreams. Recently upped to 300 mg, and I feel manic. It is bizarre, this amazing medicine now does not work. My doc said I may possibly have bipolar depression, so I still highly recommend."

9 / 10
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  • abc...
  • Taken for 6 months to 1 year
  • December 14, 2015

For Major Depressive Disorder "I have been on bupropion XL 300 for around 6 months and I'm really glad that I stuck through it. For me, it definitely got worse before it got better. Around the second and third month, my anxiety had me on edge, and I had a very short temper. The positive definitely outweighed the negative though. I'm no longer sleeping all day, I finally have the energy to work out and carry out basic activities, and no more emotional eating. As a result, I've lost 25 pounds, and it has really helped me with my confidence. Not every day is great, but that's just part of life. I'm no longer irritable, and my anxiety is not perfect, but manageable. I finally feel like I'm taking control of my life. If you can stick it out past the 3-month mark, I think it's worth a try."

10 / 10
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  • Edn...
  • July 22, 2016

For Depression "I have been taking Wellbutrin XL 450mg/day for 9 years, the brand only (I have done some personal research about brands versus generics and do not believe that generics are as good, effective, or reliable as brands). This medication saved my life, so I guess that I was lucky that it suited me. Within the first year, I remember having a dry mouth, more energy, loss of appetite, and weight loss. With time, these side effects stopped. I have no side effects now, and what this medication clearly helped me with is to still feel myself and go through my emotions without falling into the hole of depression. So I feel functional, which was not the case before taking it (for example, staying in bed because of feeling a deep sadness etc...)."

10 / 10
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More FAQ

  • cnt...
  • Taken for 5 to 10 years
  • December 21, 2014

For Major Depressive Disorder "I was diagnosed with major depression several years back. I've been on almost everything out there. I would try the medicine and hate the side effects or how it made me feel and taper myself off. Wellbutrin came on the market and I asked to be put on it. I take 300mg every day and up until recently, it was working great. As I age, other emotional problems occurred (anxiety disorder) that Wellbutrin was not helping with, and Effexor was added. Wellbutrin is the ONLY psychotropic medicine I've not had any side effects with and have stayed on as long as I have. It also helped me quit smoking after being a 25-year, 1-pack-a-day smoker."

9 / 10
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  • Pan...
  • Taken for 1 to 6 months
  • March 28, 2019

For Depression "I have had anxiety and depression all my life. It got to its worst point and started affecting my relationships where I was very irritable, upset, and just overall in a terrible mood. I came to a point where I couldn't even talk about my emptiness without crying. I was never someone to take medication but my doctor prescribed this to me. I take 1 pill a day and over the course of 2 months I was visibly seeing the changes. I had a lot of the anxiety lift away - not all of it but my mood was definitely more stable. I was able to think clearer. I don't want to increase my dose but it really helped me. I noticed when I missed a day of taking it I felt my anxiety coming back. I realized the anxiety and depression were coming back and then remembered I wasn't really consistent for a week. Just be on a schedule with this. I am thankful for this medication... And that it has improved my day to day life."

9 / 10
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  • Lem...
  • Taken for less than 1 month
  • April 10, 2018

For Depression "I started taking WELLBUTRIN when I was 14 and I’m 40 now. In between that time, I stopped and started because I was being stubborn. But after realizing that it really is a struggle for me to do it all on my own, I started taking Wellbutrin again and it’s been three weeks. I honestly have gotten so much accomplished: I communicate better, I am so focused, I don’t get really annoyed or irritated like I used to, I’m a better mom, and I’m working harder at work. I’ve only had a few side effects - slightly shaky and a few weird dreams. But I have to be honest with myself, I need to take this medication in order to be a better person. I definitely recommend sticking through it, especially if you can see better results happening in your life. Good luck!"

10 / 10
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  • Jru...
  • Taken for 1 to 6 months
  • August 12, 2014

"I never really want to share an experience about a medicine but honestly this is an awesome medicine. I was never depressed, but I had pretty bad anxiety when it came to taking tests, and I had trouble focusing and remembering things, and I am only 20. After taking this for a week, I started to wake up early and feel energized throughout the day. I felt great at work, remembering tasks, and being really nice and helpful to customers. I've been on it for almost a month now, but I feel like it's lost its effect on me just a little. I've asked to be bumped up to 300 mg. I hope it works."

9 / 10
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  • Ale...
  • Taken for 1 to 6 months
  • August 26, 2020

For Depression "After taking Lexapro, I gained weight. I did not take anything for more than a year until the depression relapse began. The doctor prescribed Wellbutrin. For the first 3 weeks, there were bouts of anger. I waited for it to pass. Then I began to have daily tears and dark thoughts. The condition is worse than before taking the medicine. I gave up, and after a few days, I felt like another person. I do not recommend it. It was a terrible experience for me."

1 / 10
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  • Ski...
  • Taken for 10 years or more
  • March 10, 2016

For Depression "I have been taking Wellbutrin 300 mg XL for over 10 years after a major depression. It was very effective at stabilizing my mood. It also helps with my mental concentration and focus. I tried the generic which didn't seem to work as well. I am under extreme stress with a challenging job and a difficult relationship (separated now) because of my partner's alcohol abuse. I was very fearful of another episode but so far have managed to remain stable. I would be lost without it."

10 / 10
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  • Ang...
  • Taken for less than 1 month
  • August 3, 2017

For Depression "I've been on medicine 150 for less than a week. I feel a little high, anxious, nervousness. But that is a relief compared to the last year sleeping upwards of 20 hours a day with no will to live. I took 300 mg. 10 years ago and lost 35 lbs within months. Already 4 days in I'm down 3 lbs quit smoking and keep trying to nap because of habit but can't sleep my life away. Thank God. I feel a little manic at times but remember this from before it will wear off. I already got up the last 2 days and exercised haven't done that in 3 years. I'll report feeling in a few months once I'm up to 300mg and stable. 1st day in 3 years where I'm not feeling dread."

10 / 10
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  • Anonymous
  • December 19, 2009

For Weight Loss (Obesity/Overweight) "I used Wellbutrin XL for two years, and in conjunction with sensible eating and a walking regimen, lost 75 pounds. I believe the Wellbutrin gave me the motivation to stick with the eating and exercise plan. It may have also provided a pharmacological effect. I've since stopped using Wellbutrin due to it not being specifically recognized as a weight loss product, but rather as an antidepressant. Choosing this product in assisting my weight loss categorized me as being depressed, and adversely affected my ability to obtain favorable life insurance premium rates. After using Wellbutrin, I was given Bupropion XL due to managed care requirements to switch to generic prescription. I stopped taking Bupropion because it proved ineffective for me."

10 / 10
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  • Kat...
  • Taken for 6 months to 1 year
  • March 16, 2014

For Depression "I have been on 150 mg of Wellbutrin with 50 mg of Pristiq daily with nominal results. My doctor upped the Wellbutrin to 300 mg and it has made all the difference. It is like day and night. I just hope I keep responding to this medication forever. It has changed my life and given me hope again. Keep trying and talking to your doctor. Good luck!"

9 / 10
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  • AHa...
  • Taken for 1 to 6 months
  • September 4, 2019

For Major Depressive Disorder "After previously being on the commonly prescribed SSRI, Prozac, the enormously unhealthy weight gain and a regression in progress prompted a change in medication. My professional thought we’d give Wellbutrin a try. It’s only been two months and I’ve quickly bounced back to the best I’ve felt in over a year (compared to months later on Prozac, but it could be attributed to better knowledge and expectations). But the weight loss has been absolutely dramatic. I’ve lost at least 40 pounds that I’d steadily gained over the last year in no more than two months."

10 / 10
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  • cas...
  • Taken for 6 months to 1 year
  • April 19, 2016

For Depression "It takes about 2 weeks to feel Wellbutrin kick in and about a month for it to be full effect. I am on 300 mg a day and take it in the morning only. If you take it too late, it will keep you awake. I am on other meds for bipolar that cause weight gain, but this med seems to be the opposite and has actually helped me lose weight. Sometimes the med 'runs out' in the afternoon and you can kind of feel the let down. It works great for depression and would be good if used by itself for weight loss. Would recommend using it, but you have to be patient with it."

10 / 10
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  • Val...
  • Taken for 2 to 5 years
  • August 10, 2013

For Seasonal Affective Disorder "I started taking Wellbutrin because of a Vitamin D deficiency and Seasonal Affective Disorder. It was like night and day. It took about 2-3 weeks, but I was no longer having crying sessions or getting angry over nothing. A Vitamin D supplement had side effects, so I had to quit taking it. I now take a multiple vitamin."

10 / 10
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  • Jus...
  • March 26, 2014

For Depression "This stuff worked wonders for me, and additionally I had absolutely no side effects whatsoever from it, so talk about a double win when we tried this medicine out. Started on 300mg and it took about 75-80% of the edge off of the depression. Proceeded to add ability (had a rare side effect, made my eyesight horrible), added Prozac 40mg (helped but made me go limp in ways a guy never likes to happen), then down to 20mg (side effects mostly went away) but still not enough, went to 600mg of Wellbutrin and have been 100% depression free for the past 1 year."

10 / 10
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  • Hor...
  • Taken for 2 to 5 years
  • April 11, 2017

For Major Depressive Disorder "My personal experience may differ for others, but the best combo for me so far has included Wellbutrin XL 300mg. Many years receiving mental health services (27 years). Had to stop SSRIs. Wellbutrin, however, helped increase my motivation, I had none. It was so bad I laid in bed for months from severe depression, I was immobile for so long that both legs filled with blood clots and I was near death! I survived on blood thinners and was in the hospital for over a week. With Wellbutrin, I had no weight gain, I lost the 50 pounds other meds helped put on me! Lowered cholesterol, quit smoking as a nice bonus, and had no sexual issues, in fact, it helped in my opinion."

8 / 10
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  • gem...
  • Taken for 1 to 2 years
  • November 10, 2012

For Depression "Wellbutrin XL has saved my life. I have been on this medication for 18 months, and my only regret is that I didn't start years earlier. I did not realize that I have been depressed for nearly 20 years, and with that came many side effects, which included a full-blown eating disorder. I was a compulsive overeater that had nothing to do with willpower. It was more like an alcoholic or drug addict. I am so happy now and love my life. Thank you, Wellbutrin XL."

10 / 10
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  • Sha...
  • August 21, 2019

For Major Depressive Disorder "I started taking Wellbutrin XR 150 mg after having major depression and tried several other medicines over 3 years. Other medicines worked well but partially, with side effects including sexual ones. Before Wellbutrin, I had no interest in doing lots of basic things I used to do. After I started Wellbutrin 150 mg, positive signs started just a few days after, with the peak after 4-5 weeks. Wellbutrin gives energy and motivation to do things. The only drawback is that this energy sometimes continues even after midnight. So sometimes I could stay awake until morning without feeling tired or mentally exhausted when I go to the office, which led to some mild anxiety. To overcome this issue, my doctor gave me another medicine to help with it. And now all is perfect. Note: you may not face the same side effects I had. Finally, I have no sexual side effects with Wellbutrin, unlike with my old medicines."

9 / 10
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  • Anonymous
  • June 25, 2016

For Depression "Absolutely recommended if your body does not like SSRIs. This medicine has helped me AMAZINGLY-before taking it, I was experiencing ridiculous mood swings going between anxious and having panic attacks to depressed and crying. This medicine has given me my life back. I am no longer trapped in the hole of depression and my anxiety, while still present, has gone from being this massive panic to contained, manageable, and approachable anxiety. Bupropion (Wellbutrin) is a stimulant, and because of this, it does make you feel stimulated. I've noticed some muscle weakness, but that's it. I switched to XL and I'm not sure how I like it yet-it seems like the releases are kind of random. Take it early if you can so you can sleep! :)"

10 / 10
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  • Vet...
  • Taken for 2 to 5 years
  • June 9, 2014

For Major Depressive Disorder "Was very depressed and hadn't slept in 4 days. Was diagnosed with manic depression and insomnia. Was put on Wellbutrin XL and trazodone for sleep. They both have been a miracle for me. No side effects from either except for dry mouth."

10 / 10
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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.