Skip to Content

User Reviews for Wellbutrin to treat Depression

Wellbutrin has an average rating of 7.0 out of 10 from a total of 445 ratings for the treatment of Depression. 62% of those users who reviewed Wellbutrin reported a positive effect, while 20% reported a negative effect.

Wellbutrin Rating Summary

7.0/10 average rating

445 ratings from 476 user reviews.

Compare all 189 medications used in the treatment of Depression.

10
27%
9
19%
8
16%
7
5%
6
4%
5
5%
4
4%
3
2%
2
6%
1
12%

Reviews for Wellbutrin

Nathalie21 June 6, 2021

“Just starting this med. The first couple days, I didn’t think it was doing much, but I noticed I couldn’t sleep for very long. I wasn’t as hopelessly sad as I had been the week prior, but I was experiencing an array of stomach-related side effects (constipated until I was very much no longer constipated, bloating, stomach aches, & VERY nauseous the first night). Fast forward a few days, I still can’t sleep very much. I’m artificially active is the best way to describe it. I’ve been pretty inactive throughout the pandemic, but I walked to get iced coffee in 90 degree heat, cleaned my apartment, had people over, then went to the gym later because I was so jittery and couldn’t sit still. It also has given me quite a bit of anxiety and some irritability alongside the constant need to be active. I hope that over the next few days, the anxious thoughts, stomach issues, & insomnia calm down.”

8 / 10
Was this helpful?YesNo
Claire · Taken for less than 1 month May 1, 2021

“I’m that patient that smokes you know what... My doctor knows. This time around being 20 now and taking this pill again, I’m on day 4 or 5 and my appetite is absolutely gone even when elevated. But I think I’m feeling more balanced out overall, but when I have my anxiety moments, they are very intense. Too soon to tell if I could recommend it, but it has interacted fine with maryJ past 4-ish days:”

6 / 10
Was this helpful?YesNo
Courtney R · Taken for 1 to 6 months April 23, 2021

“Background: depression, anxiety, intrusive thoughts, seasonal depression I went with Wellbutrin because it had the least side effects compared to most depression medications and it was recommended by many people. I must say it really has been life changing. When I started Wellbutrin it made me think much clearer. While I still do get thoughts, they are not intrusive. My mood is stable and I feel generally happy! Week 1- sensitivity to caffeine, racing heart for one day, increased energy, appetite decreased Week 2- energy balanced out, appetite low Week 3- appetite back, energy consistent, mood improving, felt happy and no intrusive thoughts Week 4- I feel great! I do sometimes experience ringing in my ear, but nothing that is bothersome. Overall, this medication has saved me. I recommend taking this medication while seeing your therapist. Both of them together have really pushed me in the right direction.”

10 / 10
Was this helpful?YesNo

Frequently asked questions

Cancer2Depression September 5, 2020

“I was a 250 pound fat and happy married man until I was diagnosed with stage 3B cancer. My wife and kids convinced me to see a Psych and get treated. Anyway, he started my on Wellbutrin (BUPROPION generic) at 200mg per day. He said this med has been around a long time and it's very safe and effective. Note that I don't have Anxiety. After a week on BUPROPION, I would sing on the way to work and was unable to take the smile off my face. After about 6 months these feelings wore off, but I was still better than before. My Psych upped the dosage to 300mg per day. I take two 100mg pills at 9am and then one 100mg pill at 230pm. Overall, I'm happy. It worked for me. Only side effects are a little insomnia twice per month and ringing in my ears 4 times per month, which lasts for hours each time. The ringing is very low. I get my meds Generic for a 90 day supply each time and my insurance charges me $24 for that 90 day supply (300mg/day).”

9 / 10
Was this helpful?YesNo
TheTwizler · Taken for less than 1 month June 1, 2020

“I'm on day 3 of wellbutrin. So far it's been miserable. I'm on the lowest dose and still having horrible stomach side effects. I can't eat, I have no appetite, severe diarrhea with intense stomach pain. I'm also exhausted but can't seem to sleep more than a few hours at a time. My mouth is dry and my eyeballs feel like sandpaper. And to top it all off, just looking at my husband arouses me. I'd actually enjoy that side effect if I could stay off the toilet. I'm gonna try to stick it out in hopes that this will pass. I know I need to give it some time.”

Was this helpful?YesNo
Kai2277 October 10, 2018

“I had an odd situation where I was not really depressed with sadness but I just felt nothing. I never got angry, never got happy- never wanted to do anything besides lay in bed. I tried to fake it as much as possible but I couldn’t anymore. I stopped answering my phone, lost all interest and motivation. I had taken all the antidepressants on the market but they made me feel crazy. My hands shook and I felt out of my body. I started researching the symptoms of low dopamine and I had almost all of the symptoms- poor memory, poor concentration, excessive worrying, lack of motivation- and overall just not giving a $#|+ about anything. I asked my doctor for Wellbutrin. In a couple of days I was calling old friends, kicking butt at work, and motivated for life again. My problem all along was dopamine not serotonin. I am thankful I figured it out. DON'T GIVE UP. Read about brain chemicals- dopamine, serotonin, and, norephenephrine- and make the choice based on research.”

10 / 10
Was this helpful?YesNo
rasinsomniac · Taken for less than 1 month May 27, 2020

“After a break up with my girlfriend and one true love of my life I went to a really dark place and had serious suicidal thoughts. I was first put on Brintellix, then Valdoxan and three weeks ago to Wellbutrin. It's been six months since the break up and after using this med for 3 weeks I'm finally able to enjoy life again and have energy to get through the days with pleasure. This med has so far been a life safer for me. First two weeks were hard and I had serious insomnia but now for the first time in 6 months I don't need Ambien to sleep anymore. I seriously recommend this med, at least for me its working perfectly so far. Just give it time to start working and you will feel better.”

10 / 10
Was this helpful?YesNo

More FAQ

Woody October 2, 2020

“I began Bupropion about a year ago. Took a while to kick in, Waiting eight weeks for the hoped-for effect was like waiting eight months. I had tried another med and it left me with negative sexual side effects which is why the doctor suggested Bupropion. I've been taking low dose Viagra, honestly don't know if I need it . . . but Viagra works. I told my doctor that I'm okay, but don't seem to feel any drastic change from when I first began the med. She suggested upping to 300 mg extended release. After a week I began to feel better but, don't know if it is from the med or the high of knowing I made the attempt at trying to feel better. Wishful thinking is a good way to put it. So here's my question: Since I was already taking Bupropion at 150 mg/day extended release should I expect the new dosage of 300 mg to take eight weeks to fully kick in? Has anyone had this experience?”

9 / 10
Was this helpful?YesNo
struggler79 January 17, 2015

“I am a 35 year old woman, who has taken meds for 1/2 her life. I struggle with obsessive compulsive disorder, intrusive thoughts and overall depression. Wellbutrin.. I take 150mg a day. It has changed my life.. I have less obsessive thinking, more motivation and for some reason care way less about what people think.”

9 / 10
Was this helpful?YesNo
Leigh · Taken for 1 to 6 months January 2, 2021

“When I tried an SSRI I ended up lying on the floor almost unresponsive. I won't take one again. In the last year my depression and anxiety got really bad. Horrible panic attacks, slamming doors, screaming, irritability... then came the suicidal thoughts. My doctor suggested Wellbutrin. I have a very sensitive body so I started on 75 mg once a day. Man. I noticed a difference within the first day or two. The third day I woke up with tons of energy and unpacked my suitcase that had been sitting in my closet for a week, before I even started working! Unheard of for me. My outlook on life has improved, I don't snap at my husband, I don't get annoyed. Plus I've lost 4 lbs and my sex drive has increased slightly. The only side effects I've had were the brain "zingers" people talk about (they have subsided) and pretty bad insomnia. I'm hoping the insomnia goes away, but right now the positives definitely outweigh the negatives! A world of difference!”

9 / 10
Was this helpful?YesNo
Pr23 December 23, 2019

“Okay, I came back to rate again. It has now been about a little over a month on Wellbutrin and wow it has saved my life. It was like a total switch in the way I think and feel everyday! For years and years I’ve been depressed but this year was so bad,I didn’t care about myself. I was also so unmotivated.. crying multiple times a day even while at work.. I’d be triggered by anything and start having anxiety attacks. Now, I can finally say I am happy with my life! It’s like I can see my life clearly now, it’s no longer a fog, I don’t obsess over all the negative things... I have energy to go to the gym often and eat right and I’ve lost over ten pounds. I have goals again and I have my self confidence back.I t feels unreal I did miss a few pills every other day for about a week and a half and I felt a difference, I cried once and I was also binge eating. But I went back to normal once I went back to taking all my pills on time.”

10 / 10
Was this helpful?YesNo
Anonymous March 30, 2021

“Saved my life and marriage after I had severe PPD and PPA. I would still have some bad anxiety every once in a while but overall totally worth it. I also found that Benadryl really helps if you have anxiety with this at night. I was able to gain the confidence to start my own business and actually believe for the first time in my life I could truly accomplish something. I pray this med helps others like it’s helped me.”

10 / 10
Was this helpful?YesNo
jkn1416 January 1, 2015

“Before starting Wellbutrin I was so depressed, crying all the time, no motivation, no energy, no ability to make decisions or follow through with them, no desire to go anywhere. I've been taking Wellbutrin for about 3 weeks and within a 5 days I was noticing a difference. The crying has stopped, I'm more motivated, I have more energy and I'm making decisions I couldn't before. I have been active, forcing myself to go to the gym but now I'm more eager to go. Wellbutrin has made a huge difference for me.”

9 / 10
Was this helpful?YesNo
AB · Taken for 2 to 5 years August 17, 2020

“I had Bipolar Disorder with depression and psychotic symptoms. I was put on Ability 15mg but I got Tardive Dyskinesia. The dosage was lowered to 10mg and then 5mg. I stopped with the psychotic symptoms immediately. But I was still depressed and not enjoying my life. So they added 150 mg Extended Release Wellbutrin and I got much better. I felt a little nauseous when I first started taking it but that stopped a few months into treatment. I still was requiring daily 1 to 2 hour naps to get through my day. Then my medicine was increased to Wellbutrin 150MG SR two times a day. Finally I felt like myself again. I had energy and felt like I could take on all my responsibilities again. It worked beautifully with Abilify for me. Hope it works for you!”

10 / 10
Was this helpful?YesNo
ZT March 12, 2014

“Five months after my Daughters fatal car accident, my Dr. suggested Celexa for my depression. I took it for 6 months. It made me worse, my Dr. thought that Wellbutrin might be better. It has really helped, just after 3 weeks I've noticed a big difference in my life. I take 200mg per day and now I can finally get on with my life knowing that some day we will be together.”

9 / 10
Was this helpful?YesNo
Anonymous October 25, 2014

“I am not a proponent of Big Pharma, and have always had to try to "deal" with my problems on my own. I have a really excellent diet, exercise, don't smoke, eat an organic diet - I'm just saying I really take care of myself. I have had anxiety (with a little bit of depression) all of my life. I was diagnosed with PTSD a few years ago, as I was having severe anxiety about being accepted into nursing school, and if I would be able to handle to stress and constant pressure, and I also have concentration problems. I have been off and on SSRIs, which have been nothing but terrible for me...Paxil, Zoloft, & Prozac, of which made me feel like a zombie. Wellbutrin is GOLD. Not tired, less irritable, not panicky. It has changed my life.”

10 / 10
Was this helpful?YesNo
Hannah · Taken for less than 1 month December 8, 2019

“Best medication I’ve ever taken. I didn’t realize how depressed I was before taking it. Now I have energy to get through the day. It also helped with my obsessive thoughts. I’ve never felt so much relief in my life. The only side effect is a slightly dry mouth but I’d take that any day over the hell I was living in.”

10 / 10
Was this helpful?YesNo
KB80 October 6, 2014

“Well I am very pleased to tell you that I started Wellbutrin XL 150mg for depression and anxiety and I can honestly say that it is a miracle drug! I started feeling much better after just one day, I could not believe it. It has been 30 days now and I have not had even one side effect. My depression went away almost right away and the anxiety took a couple weeks. But 30 days later I feel completely myself again. This medication is definitely doing its job 100%.”

10 / 10
Was this helpful?YesNo
Shy Cab February 5, 2021

“I started taking 100mg of Wellbutrin 2 months ago. I was prescribed it for ADHD but I also suffer from severe depression. The first four days of this drug were absolutely awful, I cried and felt an extreme hopelessness. After the second week the sadness was fading but I felt numb, the only positive thing is that it has decreased my irritability HEAVILY like I used to snap at so many small things and now I am unbothered but this has been replaced with sensitivity and getting emotional/crying easily. Also has helped with my sex drive. It hasn’t helped for my ADHD, I also no longer have an appetite. Two days ago I was bumped up to 300mg a day and the first day taking it I went back into the same despair I felt, but the suicidal thoughts were worse this time but luckily my boyfriend was there. I’m not sure if this is worth taking in the long run but I’d rather be more emotional then have the irritability come back. Wishing everyone suffering from depression lots of love:)”

6 / 10
Was this helpful?YesNo
sad panda no more · Taken for 1 to 6 months January 22, 2019

“Wow. What an amazing drug. I have been on cymbalta for about 5 years, it was a life saver after a really bad period but began to lose its effectiveness. My doctor added wellbutrin 200mg and I feel like my old self again. Lots of energy, no feeling like the day is to hard to attack. No more feelings about giving up. No need for my daily nap. Wish I would have tried it 20 years ago could have saved a lot of needless pain. I am 40 now and have only been treated for depression for the last 5 years. If anyone out there feels sad all the time for no reason go to your doctor, it doesn't have to be that way. Anyway loving wellbutrin.”

10 / 10
Was this helpful?YesNo
Dee · Taken for 6 months to 1 year December 15, 2019

“I have suffered with anxiety and depression since I was around 16 years old..I am 32 now and I have tried many different antidepressants none of which really helped until I was put on wellbutrin about a year ago. It took a little while of me taking it before I really noticed a difference, but I stuck with it and I am so happy I did. I have completely given up smoking cigarettes (have been smoking regularly since 18) and it has saved my marriage...my mood has changed completely! I feel so thankful for life now and I look forward to the future. Wellbutrin saved my life.”

10 / 10
Was this helpful?YesNo
Sara987 · Taken for 1 to 6 months February 17, 2017

“This has become my miracle medicine. Some days I wonder if it's too good to be true!! I've battled depression and anxiety on and off for years. My doctors over the years kept giving me different SSRIs and those made me like a zombie barely able to get out of bed. With a toddler that's just not an option! I've been on it for about 6 weeks now and let me tell you the benefits: I'm HAPPY - like I have a desire to move and do things as opposed to sitting on the couch after work not wanting to do a thing until bedtime. It's almost like I'm on speed. I'm SO productive at work and home. I'm sleeping better - I was worried it would keep me awake but nope. Sex drive thru the roof. I've lost 10 lbs so far from suppressed appetite and working out!”

Was this helpful?YesNo
It Can Work Fast · Taken for less than 1 month November 25, 2014

“My wife passed away and I went into a deep depression. I was put on Wellbutrin and told by my nurse it would be at least 4 weeks. In just 3 days and I was feeling great, clear headed, I smiled, I ate normally.”

10 / 10
Was this helpful?YesNo
depressed no more · Taken for 1 to 2 years December 10, 2014

“I have been on bupropion for about a year, 150mg taken every morning. I noticed a difference on day 2. Everything was just normal. Not bad normal, but good normal, like you woke up after having a really good sleep - and like a weight or pressure has been lifted. It's really hard to describe. Everything seems better. I kid you not. Music sounds clearer, looking around outside, it looks clearer...like I am out of a fog. So...I tried an experiment while I went on vacation. Didn't take anything for 2 weeks. My mood slowly returned to negative. Little things ticked me off, that shouldn't have. I decided to go back on. Same effect on the next day, mood lifted. It gives me slight insomnia, but also takes away some appetite. Great.”

10 / 10
Was this helpful?YesNo
Tessa January 14, 2019

“I started taking generic Bupropion XL 150 my once a day 8 days ago. The anxiety and depression I was feeling were paralyzing me from moving in any direction. I tried every natural option I could research. On day 1 I felt different, motivated and better immediately. In the days following side effects started. Heart palpitations, anxiety, afraid of everything, nightmares, a rash on my neck, eye twitching, staring into space thoughtless unable to make decisions, fear of leaving the house. Day 8 and I’m feeling much more at peace. I’m more focused on myself than issues I have with others. No insomnia and feeling less tolerant of binge drinking to calm down. I want to exercise, clean my house, set goals, eat clean foods and I feel everything is going to be ok. My self confidence is improved and orgasms unaffected. I am hopeful that Wellbutrin was exactly what I needed to be the healthy person I need to be no matter what happens in my life. I just needed a boost and reset.”

8 / 10
Was this helpful?YesNo
new me10 · Taken for 1 to 6 months November 20, 2013

“I was deeply depressed. I slept a lot, I lost interest in work (and I am self-employed). I suffered from chronic procrastination, lost many clients and went to trouble with my bank, an awful period. I tried SSRIs like sertraline and Lexapro but it didn't help me rise up and boost my motivation. Since I have discovered after 50 years that I am also suffering from ADD. I read about Wellbutrin. I tried 150 mg with no significant change for a month, and then, switch to 300 mg. What a change! I am full of energy, focused, full of self confidence, working full hours, and enjoy writing. ”

10 / 10
Was this helpful?YesNo
BEX October 17, 2019

“I have been on so many antidepressants in the last 17 years. You name it, i've probably tried it. Yet not once was Wellbutrin recommended to me until a couple of months ago when I told my doctor I keep going off of my meds because of the awful side affects. My daughter was recently diagnosed with ADHD and her shrink told me I should be evaluated for it as well. I told my doctor about my thoughts on being evaluated for ADHD and that I was a lot like my daughter when I was younger. She told me that Wellbutrin used to treat ADHD off label. The first month I was on 150mg XL I felt better but not amazing. I told her as much at my checkup. She upped it to 300mg. Within 4 days, I felt like myself but better! I quit vaping, started running again, started cooking and many other hobbies I haven't done in years because I have been so depressed. I feel more focused at work and have had zero sexual side effects which has never happened on any other antidepressant. I will never switch back to an SSRI again!”

10 / 10
Was this helpful?YesNo
Janedoe March 7, 2020

“DO NOT TAKE THIS IF YOUR PRIMARY ISSUE IS ANXIETY. I got on this medication because I was having trouble with anxiety and insomnia. My NP wanted to start me on Wellbutrin 150mg XL and I kept reiterating to her that I have no depression what so ever, I’m just anxious, but she said it would help. Within 2 weeks I was so nauseated, in a complete brain fog, my anxiety got so much worse, my heart would race, I was having panic attacks daily, couldn’t sleep, my mind was racing non stop, and although I’ve never felt as if I had issues with depression I was so depressed on this medication! I went from being very high functioning with mild to moderate anxiety to completely useless on this medication. I called into work multiple times (which I had never done before-I’m a nurse) I couldn’t focus was so disoriented and felt like I was just floating. I stopped and feel much better after a few days and I got on a prn benzo for anxiety.”

1 / 10
Was this helpful?YesNo

This information is NOT intended to endorse any particular medication. While these reviews might be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare practitioners.