Rexulti for Depression User Reviews (Page 2)

• Liz...
• October 20, 2020

"I was taking Rexulti for about 8 months. At first, it was amazing, and all of a sudden, everything went downhill. I will NEVER go back on the drug. It made me extremely depressed, suicidal, and reckless. It put me in a mental hospital because of how dark my mood went. This medication is awful!!!!"

• squ...
• January 17, 2017

"Started and have stayed on the very lowest mg. of Rexulti. (For roughly four months.) Almost immediately I felt so much better, and as the days went on, I felt 'alive' again. Did have an issue with hot flashes, but it didn't last long. My Pdoc is trying to see if I can get a reduction on the cost of this med. Hope he can, because if not, I have no other med that works for me, and it's back to doomsville again. I have D.I.D., PTSD, anxiety, and panic disorder. This drug really keeps me focused and on an even emotional keel. Very pleased."

• Anonymous
• Taken for 1 to 6 months
• January 29, 2019

"I was put on 0.25 mg of Rexulti to help the effect of my Lexapro. After increasing the Rexulti to 0.50, I had my first major seizure. I was taken to the hospital, and they said it was probably a non-epileptic seizure. I called my doctor, who said it could not be caused by the Rexulti and increased the dosage to 1 mg. After that, my seizures increased to three or four times a week. I weaned myself off Rexulti, and now I am seizure-free. Please be careful with this drug."

• Anonymous
• Taken for 1 to 6 months
• May 27, 2020

"I started on Rexulti at the low dose of 0.5 mg. It was really helping with my breakthrough depression. I have been taking Wellbutrin for about 2 years, and I needed a little boost. Well, 2 months later, and I gained 10 pounds. Super disappointed. The medication works, but be ready to be depressed about how much weight you've gained from it. Won't recommend."

• lri...
• August 9, 2019

"This is my 3rd time trying Rexulti. Honestly, the first 2 times I took this medication, my other psychiatrist only gave me 2 mg. It did not work for me. But, I switched psychiatrist, and they gave me 4 mg for my depression. What a major difference. I am on Weight Watchers Freestyle, and I actually lost 3 lbs on this medication while doing this program. Yes, it can cause weight gain. But, as soon as I started taking this medication, I immediately went on Weight Watchers Freestyle. The only thing is my sugar was high when I got blood work. You really need to watch your sugar when on this medication and eat a healthy diet. People say this medication causes weight gain, so you have to be really careful and watch what you eat."

• Jil...
• Taken for less than 1 month
• May 28, 2022

"I’ve read these reviews, like you, desperately hoping that I could find a medication that worked for me. I’m ultra-sensitive to psych meds, am a slow metabolizer, and can’t take any SSRIs or SNRIs. I’ve had anxiety and depression for 23 years that started postpartum, and I am a 56-year-old female. Rexulti, when added to my AD Nortriptyline, worked in 3 days to calm the agitated, panicky anxiety I was still struggling with. I take it in the morning, 0.5 mg, and I don’t have any side effects. First time ever! I urge sensitive people to try this! God bless all of you that are struggling and trying!"

• Geo...
• November 7, 2016

"I was prescribed Rexulti when my daily depression meds began to no longer work for me. It started working almost instantly. I have been on Rexulti along with my daily meds, and I have been feeling better than ever."

• Jhm...
• Taken for 6 months to 1 year
• August 17, 2018

"I am one of those people who went through every antidepressant ever (Paxil, Pristiq, Effexor, Wellbutrin, etc.). Finally, I landed on Prozac. I felt much better, but far from okay. After several months, Rexulti was added. I am one of the lucky ones, I suppose, because within hours I knew I had just won my own personal lottery - a medication combination that worked for me. I now know what I have never known my whole life - what it's like to feel normal. I feel like this drug combination saved my life. My wife and kids do too. Best of luck to those struggling, because it took me 36 years to get the combination right. I tried it all. I recommend trying this combination to all. If it doesn't work, keep trying. It's worth the frustration when you feel it for the first time - normalcy. It is expensive unless you are willing to fill out the paperwork and get it for free."

• Not...
• January 10, 2020

"I was on this for a depressive episode / delusions. The side effects doctors won’t tell you about that happened to me: high blood sugar, high blood pressure, fast weight gain, lethargy, heart palpitations, constant panic attacks, insomnia, migraines, stomach and digestive issues, and much, much more that ruined my entire summer. BTW: it only “works” for two weeks to a month, then it stops completely, as shown by literally half of the reviews on this. Disgusting. Put in more research before shoving experimental antipsychotics into people's mouths whenever they even feel a tad bit sad."

• LFR...
• September 25, 2018

"I have had depression for years. I have ADHD also. I take Wellbutrin, Adderall, and Trazodone for it all. I have been on Rexulti for 3 weeks now. I have not gained any weight. I have lost 10 lbs so far with WW on it. I am a full-time college student. Rexulti has helped me more with my ADHD symptoms. It has helped with my concentration also. I am glad they finally have come out with something that I am able to actually lose weight on."

• Ban...
• Taken for 1 to 2 years
• May 2, 2019

"Rexulti works if you are in a rough spot, but I have gained 80 lbs using this. My brain works, but the weight gain is not healthy for me. My doctor and I have agreed to discontinue this medication and are looking into alternatives. I lost 15 pounds the first week I lowered my dosage in half. I will continue to reduce the dosage until it is out of my system. Anyone that uses this, I would recommend keeping tabs and seeing what effect it has on your body during the first few months."

• Liz...
• June 29, 2017

"I have chronic depression (dysthymia) and anxiety, and the depression worsened recently despite being on Zoloft and Wellbutrin. My psychiatrist suggested we try Rexulti and wean me off the Wellbutrin. I started on 1 mg, and I had a slight headache for the first two days. After that, I felt like I was doing a little better, and my husband commented that I was more active than usual. My dose went up to 2 mg a couple of days ago. Now I feel like I can really tell a difference! I haven't felt depressed, I have more focus and creativity at work, and I've actually had enough motivation to do chores at home. I'm a little restless, which I'll keep an eye on, but I haven't noticed any other side effects besides that and the temporary headache. I'm optimistic!"

• Cut...
• Taken for 1 to 6 months
• August 30, 2018

"I think I have finally found what works for me! It took a lot of trial and error. I am currently on Pristiq (the generic kind) 100 mg, Rexulti 1 mg, and Vyvanse 75 mg every day. I take the Vyvanse and half a mg of Rexulti in the morning and Pristiq and another half a mg of Rexulti at night. The 1 mg Rexulti all at once gave me anxiety by the end of the day. Now I have back my passion, my drive, and excitement for life! I have anxiety, depression, and ADD, but these medications balance out everything correctly."

• Gre...
• Taken for 1 to 6 months
• October 1, 2020

"I was taking Zoloft for depression, and Rexulti was added to it. At first, I felt great, but after about 2 weeks, I became very reckless. I didn’t care about anything. I didn’t care about the consequences of my actions. I did lots of stupid stuff. I stopped taking it."

• Pep...
• Taken for 6 months to 1 year
• February 20, 2020

"I was given Rexulti as an add-on for depression. At the time, I was constantly in a dark place. Lots of thinking of death. Not suicidal. It helped overnight. However, I had some bad side effects. Tardive dyskinesia of the mouth. Although not in the way this condition is talked about. I was unable to chew. It was as if I lost that automatic chewing. I lost weight as I was unable to really eat anything except fluids. I was then put on yet another medication (can't recall the name). This helped a little but did not help the way I had hoped. I decided to go off the Rexulti cold turkey, and I felt as though my body was failing me. I felt worse than the flu. I gave it 2 weeks before I had to start taking it again. Now I am slowly tapering to lower doses. Please listen when I say DO NOT go off cold turkey. I was on 3 mg. I am now on 2 mg and hope to change the dose to 1 mg next."

• WR2...
• Taken for less than 1 month
• August 17, 2017

"I've been trying different combinations of medicines for a good 6 years. I was put on Trintellix about a year ago, and that helped some, but my depression was still disabling. Recently, I went to my psychiatrist and asked for a change in medication. She decided to add Rexulti as an add-on to my Trintellix. The result has been phenomenal. I feel better than I have in years. I have more energy, I'm less anxious, and I've been able to leave my house without feeling overwhelmed at all. This medicine is working VERY well for me."

• Riv...
• Taken for 1 to 6 months
• May 2, 2020

"I have been on Rexulti 4 mg with Wellbutrin XL 300 mg, Zoloft 200 mg, and Adderall 90 mg a day. Rexulti is for my depression. Yes, I have gained some weight, but I feel better on 4 mg of Rexulti. I need to figure out how to lose weight with this drug. But I also have other thyroid issues that mess with my weight constantly. I would rather be happy and gain a little weight than be miserable. I have come to the conclusion that the medications are what you make it. I feel lots of relief from my depression. For years, I felt like, even with 2 antidepressants, I need something to stabilize me more. This Rexulti is the only medication that doesn't change my personality or change who I am as a person."

• dee...
• Taken for 1 to 6 months
• December 15, 2022

"Effective as anything, but at great cost. It quickly quieted my intrusive thoughts and gave me a boost of energy. But only 4 months later, I've gained 35 lbs on only 1 mg of Rexulti. My BMI is over 25. My doctor says the sugar cravings and impulsive shopping are a good sign because it's dopamine-seeking activity. My mental health is better than it has been in years, and I'm going to be stopping this medication because of its detrimental effects on my weight, blood sugar, cholesterol, and self-esteem. I don't even recognize my own body anymore. Not how it looks and not how it feels to move around in it. I almost wish I'd never experienced this because it feels like a tragedy to find something that works so well and not be able to keep taking it. It's, quite ironically, super depressing."

• No...
• Taken for less than 1 month
• June 5, 2016

"I have been on citalopram (Celexa) 40 mg for years, and it just wasn't working anymore. My psychiatrist added the Rexulti 0.5 mg three weeks ago, and I have never felt better! I take them both at bedtime. The only real side effect is nausea sometimes in the middle of the night. I am so grateful to be able to live again. My doctor has given me a month’s more samples while they work to try and get my insurance to accept this new medication. I hope they do because my pharmacy quoted me $1,000 (not a typo) for my prescription!"

• Hap...
• Taken for 1 to 6 months
• July 19, 2024

"0.5mg I felt like my life was given back to me. I felt the urge to stop drinking and going back to the gym. I was making plans for the future, even thinking straight. I felt 30 years younger again. Loved shopping again... can't say enough. Did get some cherry stools but I had eaten cherries. I actually lost weight."

• Kel...
• Taken for 2 to 5 years
• May 1, 2020

"Ok, so I've been on Rexulti for a few years now for depression. This is the best advice I can give someone thinking about taking this medication. Currently, I am on 2 mg, I take it for major depression. My doctor started me off on 1 mg. It seems like I had side effects from the drug in the beginning: dry mouth, weight gain, irritability, and fatigue. So I started taking it at night. After about 2 weeks, I then switched to morning again. Side effects went away except for me eating :(. Overall, it's a good drug if it helps. I would recommend it. DOWNSIDE: do not just stop taking the drug! You must taper down on the medication. You will have effects if you just stop taking it. For example, moody as heck. Then it takes a few days to build the medicine back up in your body for it to go away."

• Rob...
• Taken for 2 to 5 years
• November 3, 2024

"I started taking Rexulti about 2 years ago. I was in the middle of a total mental breakdown. I've struggled with anxiety since I was 12 and been medicated since 13. But for some reason, in 2020, at age 21, I became inconsolable and unstable. I was in the ER twice in one week for panic attacks that got so severe I thought I'd die. I was miserable, my body felt like it was shutting down, but every test was normal. I was ready to give up. All the medicines I tried failed - clonazepam, aripiprazole, everything. Then my psychiatrist found Rexulti. Within a matter of days, I was cured. I felt great. I felt alive. I felt even better than I did before the breakdown. And ever since, I've been doing amazing. I love life again and am safe and happy. I only take 0.5 mg a day, in addition to my venlafaxine 225 mg. My psychiatrist thinks this works as an additive to the venlafaxine and bolsters the effects. Whatever it is, I'm so thankful for what this treatment has done for me. It saved my life."

• Mel...
• February 19, 2020

"I have been on Rexulti for approximately a month now, starting at the 0.5 mg dose and now I am titrating up to 1 mg. I’m on an 8-day cycle of alternating between the 0.5 mg and 1 mg, respectively. This medication was prescribed to me as an add-on to Persistent Depressive Disorder (dysthymia) by my psychiatrist. I am also prescribed Wellbutrin XL 300 mg and Cipralex 20 mg. This cocktail seems to help me enough to get up for work and continue my duties in home life as a husband and father without considering killing myself. Before I was given Rexulti, I was semi-suicidal daily, so I guess it is helping. It is supposed to stabilize mood and give me an extra boost to get going, however, I do feel somewhat sedated while on this drug, especially on the days I take 1 mg, which to me is not a bad thing. I would rather feel okay and sedated vs. sad but energetic."

• rex...
• May 5, 2016

"In my third week of 5 mg as an add-on to Paxil. After the first week, I thought to myself, 'So this is what it's like to feel good, upbeat, and happy.' Now this week, I definitely notice an increase in appetite, constantly snacking and looking for something to eat. That will not make me happy, as weight issues were already a problem. Also a bit troublesome is I am feeling tingling in my arm from the wrist all the way up to my elbow. Tingling numb, something is off. My guess it's the Rexulti. See the doctor on Monday and will update. If it gets worse, I will follow up sooner."

• Kat...
• Taken for 1 to 6 months
• April 22, 2021

"I'm rating this a 10 because I've never had a med work so well on my bipolar depression, and the effect was immediate! I can do things again with ease and not be unsteady. I couldn't even get out of bed most days, now I'm up early, I shower and take care of myself, see friends, do hobbies like painting, writing, and exercising. I laugh again, and it felt like a light switch turned on in my brain. Very thankful for this medication. I take it along with Lamictal."