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Acetaminophen / aspirin / caffeine and Upset Stomach: What Users Say

Brand names: Excedrin, Excedrin Migraine, Migraine Relief, Goody's Headache Powders, Excedrin Extra Strength, Pamprin Max Menstrual Pain Relief, Migraine Formula, Extra Pain Relief, Goody's Extra-Strength Headache Powders, Goody's Extra Strength, Bayer Migraine Formula, Arthriten, ConRx Pain Reliever, Genace, Anacin Advanced Headache Formula, Backaid Inflammatory Pain Formula, Arthriten Inflammatory Pain Formula, PainAid Extra-Strength Formula CVS Extra Strength Headache Relief Medique Pain-Off Vanquish …show all brand names

Upset stomach: mentioned by 10 users (2.6%)

Based on user experiences from 387 Acetaminophen / aspirin / caffeine reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

nausea 7.2%
anxiety 4.9%
dizziness 3.1%
vomiting 2.8%
upset stomach 2.6%
increased heart rate 2.1%
tremors 2.1%
headaches 1.6%
lightheadedness 1.6%
stomach pain 1.3%

Reviews for Acetaminophen / aspirin / caffeine

Showing 10 reviews tagged with "upset stomach". Clear filters to view all 387 reviews.
Commonly mentioned side effects
  • Par...
  • Taken for less than 1 month
  • February 15, 2019

For Migraine "I had a very bad reaction. My stomach burning, cramping, and feeling nauseated, very ill to the point I had to go to urgent care. Now it’s going on 4 days feeling sick. Be glad when this gets out of my system. Never ever take this again."

1 / 10
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12 Report
  • She...
  • Taken for 5 to 10 years
  • April 8, 2019

For Pain/Fever "What is wrong with Goody's now? I have been taking them for years, they never made me sick. Now it upsets my stomach. And it no longer works. You changed something that was very good to something that is very bad. I'm done with Goody's powders."

1 / 10
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8 Report
  • Anonymous
  • June 8, 2010

For Migraine "I have over 20 migraines a month, which can be very costly with Imitrex. If I catch my headache early enough, Excedrin for Migraines will eliminate my migraine for 8-12 hours. It is tough on my stomach, though, after years of fighting migraines with aspirin (before Imitrex came along). Thank you, Excedrin!"

10 / 10
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17 Report
  • Gma...
  • May 25, 2011

For Migraine "I have lived with migraine headaches for over 24 years. I did not know what to do with my head until I found a miracle 7 years ago. I am from the country where access to medication is not possible, so I had to learn how to live with an ongoing headache for several years. One day I was sitting in the lab with a female colleague, and she saw me rubbing my head badly. She carried the pills, so she pulled out and gave me two. In 15 minutes, I felt the most amazing relief I never had in 17 years. I totally depend on Excedrin Migraine pills for the last 7 years now. I feel stomach burning afterward, but that discomfort does not match the migraine headache. I take it twice or three times a week."

9 / 10
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16 Report
  • Sro...
  • June 30, 2015

For Migraine "Kills my migraines, but kills my stomach too. Sometimes I just have to decide which is the lesser evil. Intense migraines trump hours of burning stomach, but the sensation of digesting razor blades trumps mild migraines. Know your body and medicate accordingly."

5 / 10
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11 Report

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  • Any...
  • Taken for 5 to 10 years
  • April 25, 2015

For Migraine "I am absolutely in LOVE with Excedrin Migraine! Whenever I have the worst migraine, I always take this pill, and it goes away so fast. I've been having migraines since I was about 11, and at first, I would take Advil because I didn't know about Excedrin. But, as soon as I found this, I never went back. I swear by this pill. It's the only thing that really works for me. I don't know why for me it doesn't give me a stomach ache. I just took some this morning because I had the worst migraine, and I couldn't wait to eat something first. But my stomach is fine still. I would 1000% recommend Excedrin to anyone!"

10 / 10
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7 Report
  • Kay...
  • Taken for 10 years or more
  • April 12, 2021

For Migraine "I started using Excedrin Migraine in my twenties for migraines. I'm now 62 and continue to use it. It's a miracle drug for me. I do get stomach upset from it, so I try to take it with food. I can't take it around bedtime because I could never sleep (caffeine is in it). I take one pill. I took 2 once, and the shakiness and anxiety were through the roof. I hope they never stop manufacturing this product."

10 / 10
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  • CCa...
  • Taken for 10 years or more
  • February 5, 2020

For Pain/Fever "Used this for TMJ pain instead of narcotics. Relief comes fast. The only OTC that works: Excedrin. I have used generic brands from Wal-Mart, Walgreens, or Meijer brands of Excedrin too. All are great. I go by cost and coupons. Tylenol alone does nothing. Advil works sometimes but causes stomach irritation. Excedrin can cause a spike in blood pressure, which is monitored. My endocrinologist monitors but approves Excedrin."

10 / 10
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  • edw...
  • May 7, 2009

For Pain/Fever "It is the only medicine I had fast results with and more effective than all the prescription medicines I have tried in the past, but it has irritated my stomach a lot."

9 / 10
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6 Report
  • Anonymous
  • August 3, 2010

For Osteoarthritis "Works good for the back and body. Works a little better. Be careful not to take too much because it will mess up your stomach."

6 / 10
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2 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.