Skip to main content

Acetaminophen / aspirin / caffeine and Headaches: What Users Say

Brand names: Excedrin, Excedrin Migraine, Migraine Relief, Goody's Headache Powders, Excedrin Extra Strength, Pamprin Max Menstrual Pain Relief, Migraine Formula, Extra Pain Relief, Goody's Extra-Strength Headache Powders, Goody's Extra Strength, Bayer Migraine Formula, Arthriten, ConRx Pain Reliever, Genace, Anacin Advanced Headache Formula, Backaid Inflammatory Pain Formula, Arthriten Inflammatory Pain Formula, PainAid Extra-Strength Formula CVS Extra Strength Headache Relief Medique Pain-Off Vanquish …show all brand names

Headaches: mentioned by 6 users (1.6%)

Based on user experiences from 387 Acetaminophen / aspirin / caffeine reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

nausea 7.2%
anxiety 4.9%
dizziness 3.1%
vomiting 2.8%
upset stomach 2.6%
increased heart rate 2.1%
tremors 2.1%
headaches 1.6%
lightheadedness 1.6%
stomach pain 1.3%

Reviews for Acetaminophen / aspirin / caffeine

Commonly mentioned side effects
  • unf...
  • Taken for 6 months to 1 year
  • July 27, 2022

For Migraine "As someone who's been experiencing severe chronic aura migraines (5-7 days/week) since age 10 (17 now), I have tried a lot of different pain medications. Due to my hEDS, drugs such as acetaminophen and Excedrin work for some months before I grow a tolerance to them. I tried everything: lowering my dosage, taking fewer pain meds, going cold turkey and trying again a month later, but alas nothing seemed to work until I heard about Vanquish. I've been taking Vanquish for a little less than a year now and my dosage of 2 pills still works within 30 minutes to 1 hour with no noticeable side effects. Unfortunately, Vanquish is not a miracle drug and after taking it, I still usually have a slight headache and the occasional visual aura, but it has allowed me to live my life again. My only suggestion is to avoid taking it with Benadryl. I had an allergic reaction and needed it an hour after taking Vanquish, leading to an experience I can only imagine is comparable to taking copious amounts of meth."

9 / 10
Was this helpful?YesNo
1 Report
  • Sun...
  • Taken for less than 1 month
  • May 3, 2022

For Migraine "Been getting migraines a lot more frequently lately. The last one I had, I ended up in the E.R. The prescription they sent me home with (ket.. something I think.. ketorol?? Idk but) whatever it was, didn't work! Yesterday another migraine set in. I spent last night in the tub in the dark, soaking my throbbing neck and shoulders in hot water and allowing the water to ease my nausea (as I always do with my endometriosis). I had my husband get me some coffee (for the caffeine), some chicken soup (to get something in my stomach to help with the nausea), and an ice pack for my head. I also took the last pain pill I had from the E.R. The pain subsided some but not for long. This afternoon I BEGGED my husband to get me some Excedrin Migraine because I looked up online what to take and that was the first thing that popped up, along with some more coffee. I took 2 of the Excedrin 30-40 mins ago, and the stabbing in my left temple is gone. I still have a bit of a headache, but nothing I can't handle!"

7 / 10
Was this helpful?YesNo
0 Report
  • mir...
  • April 29, 2016

For Pain/Fever "Because I have a Morena birth control, headaches are a side effect and can be as painful as a migraine. I ran out of ibuprofen, so my husband told me to get more but try Excedrin. My headache was gone within 30 minutes, and I had energy. I'm never going back to ibuprofen again. Plus, 4 hours later, my headache is still gone, no need to pop more pills!"

10 / 10
Was this helpful?YesNo
1 Report
  • Old...
  • Taken for 10 years or more
  • July 16, 2019

For Pain/Fever "New packaging intensifies my headache when I am struggling to get the product separated from the new package - why not offer both, if you please -"

2 / 10
Was this helpful?YesNo
11 Report
  • Plu...
  • October 19, 2018

For Migraine "The best product for pain relief, but gives me a headache just trying to use the new packaging. PLEASE go back to the original packaging."

1 / 10
Was this helpful?YesNo
7 Report
  • Anonymous
  • Taken for 10 years or more
  • July 17, 2021

For Migraine "I am going to stop buying Goody's because of the packaging. Getting all the powder out makes my headache worse. Big mistake. Big."

3 / 10
Was this helpful?YesNo
0 Report

Are you taking this medicine?

Your review helps others make informed decisions.
Write a review
Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.