Acetaminophen/aspirin/caffeine Interactions
There are 579 drugs known to interact with acetaminophen/aspirin/caffeine, along with 21 disease interactions, and 6 alcohol/food interactions. Of the total drug interactions, 72 are major, 433 are moderate, and 74 are minor.
- View all 579 medications that may interact with acetaminophen/aspirin/caffeine
- View acetaminophen/aspirin/caffeine alcohol/food interactions (6)
- View acetaminophen/aspirin/caffeine disease interactions (21)
Most frequently checked interactions
View interaction reports for acetaminophen / aspirin / caffeine and the medicines listed below.
- Adderall (amphetamine / dextroamphetamine)
- Adderall XR (amphetamine / dextroamphetamine)
- Advil (ibuprofen)
- Aleve (naproxen)
- Ambien (zolpidem)
- Aspirin Low Strength (aspirin)
- Benadryl (diphenhydramine)
- Benadryl Allergy (diphenhydramine)
- Celebrex (celecoxib)
- Claritin (loratadine)
- CoQ10 (ubiquinone)
- Cymbalta (duloxetine)
- Fish Oil (omega-3 polyunsaturated fatty acids)
- Glucosamine & Chondroitin with MSM (chondroitin / glucosamine / methylsulfonylmethane)
- Imitrex (sumatriptan)
- Lamictal (lamotrigine)
- Metoprolol Succinate ER (metoprolol)
- Probiotic Formula (bifidobacterium infantis / lactobacillus acidophilus)
- Prozac (fluoxetine)
- Singulair (montelukast)
- Synthroid (levothyroxine)
- Topamax (topiramate)
- Tylenol (acetaminophen)
- Vitamin B Complex 100 (multivitamin)
- Vitamin B12 (cyanocobalamin)
- Vitamin C (ascorbic acid)
- Vitamin D3 (cholecalciferol)
- Xanax (alprazolam)
- Zinc (zinc sulfate)
- Zyrtec (cetirizine)
Acetaminophen/aspirin/caffeine alcohol/food interactions
There are 6 alcohol/food interactions with acetaminophen / aspirin / caffeine.
Acetaminophen/aspirin/caffeine disease interactions
There are 21 disease interactions with acetaminophen / aspirin / caffeine which include:
- alcoholism
- liver disease
- coagulation
- cardiac disease
- hypertension
- psychiatric disorders
- PUD
- asthma
- GI toxicity
- renal dysfunction
- Reye's syndrome
- PKU
- cardiotoxicity
- liver disease
- renal dysfunction
- seizure disorders
- GERD
- anemia
- dialysis
- G-6-PD deficiency
- hepatotoxicity
Report options
More about acetaminophen / aspirin / caffeine
- acetaminophen/aspirin/caffeine consumer information
- Compare alternatives
- Pricing & coupons
- Reviews (387)
- Drug images
- Latest FDA alerts (4)
- Side effects
- Dosage information
- During pregnancy
- Drug class: analgesic combinations
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
See also:
Ubrelvy
Ubrelvy (ubrogepant) tablets are used for the acute treatment of migraine. Includes Ubrelvy side ...
Nurtec ODT
Nurtec ODT (rimegepant) is used to treat acute migraines and prevent episodic migraines, by ...
Qulipta
Qulipta is used to help prevent episodic or chronic migraine headaches in adults. Qulipta is an ...
Paracetamol
Paracetamol (Panadol, Calpol, Alvedon) is a widely used over-the-counter painkiller and fever ...
Propranolol
Propranolol is a beta-blocker that is used to treat tremors, chest pain, high blood pressure, heart ...
Diclofenac
Diclofenac is a nonsteroidal anti-inflammatory drug used to treat pain and inflammation associated ...
Naproxen
Naproxen is a nonsteroidal anti-inflammatory drug used to treat pain or inflammation caused by ...
Amitriptyline
Amitriptyline is a tricyclic antidepressant used to treat depression and, off-label, conditions ...
Duloxetine
Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor antidepressant used to ...
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
