Acetaminophen / aspirin / caffeine Drug Interactions
A total of 411 drugs are known to interact with acetaminophen / aspirin / caffeine.
- 54 major drug interactions
- 276 moderate drug interactions
- 81 minor drug interactions
Check for interactions
Most frequently checked interactions
View interaction reports for acetaminophen / aspirin / caffeine and the medicines listed below.
- acetaminophen / caffeine
- Adderall (amphetamine / dextroamphetamine)
- Aleve (naproxen)
- Ambien (zolpidem)
- Aspirin Low Strength (aspirin)
- aspirin / caffeine
- Benadryl (diphenhydramine)
- Celebrex (celecoxib)
- CoQ10 (ubiquinone)
- Cymbalta (duloxetine)
- Fish Oil (omega-3 polyunsaturated fatty acids)
- Flexeril (cyclobenzaprine)
- Morphine Sulfate ER (morphine)
- Omega-3 (omega-3 polyunsaturated fatty acids)
- Singulair (montelukast)
- Synthroid (levothyroxine)
- Tylenol (acetaminophen)
- Vitamin B12 (cyanocobalamin)
- Vitamin C (ascorbic acid)
- Vitamin D3 (cholecalciferol)
- Xanax (alprazolam)
- Zyrtec (cetirizine)
Acetaminophen / aspirin / caffeine alcohol/food interactions
There are 6 alcohol/food interactions with acetaminophen / aspirin / caffeine
Acetaminophen / aspirin / caffeine disease interactions
There are 21 disease interactions with acetaminophen / aspirin / caffeine which include:
- alcoholism
- liver disease
- coagulation
- cardiac disease
- hypertension
- liver disease
- PUD
- asthma
- GI toxicity
- renal dysfunction
- Reye's syndrome
- PKU
- cardiotoxicity
- psychiatric disorders
- renal dysfunction
- seizure disorders
- GERD
- anemia
- dialysis
- G-6-PD deficiency
- hepatotoxicity
More about acetaminophen/aspirin/caffeine
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Images
- Compare Alternatives
- Pricing & Coupons
- 264 Reviews
- Drug class: analgesic combinations
- FDA Alerts (3)
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
