Acetaminophen/aspirin/caffeine Interactions
There are 588 drugs known to interact with acetaminophen/aspirin/caffeine, along with 21 disease interactions, and 6 alcohol/food interactions. Of the total drug interactions, 72 are major, 442 are moderate, and 74 are minor.
- View all 588 medications that may interact with acetaminophen/aspirin/caffeine
- View acetaminophen/aspirin/caffeine alcohol/food interactions (6)
- View acetaminophen/aspirin/caffeine disease interactions (21)
Most frequently checked interactions
View interaction reports for acetaminophen / aspirin / caffeine and the medicines listed below.
- Adderall (amphetamine / dextroamphetamine)
- Adderall XR (amphetamine / dextroamphetamine)
- Advil (ibuprofen)
- Alcohol (contained in alcoholic beverages) (ethanol)
- Aleve (naproxen)
- Ambien (zolpidem)
- Aspirin Low Strength (aspirin)
- Benadryl (diphenhydramine)
- Benadryl Allergy (diphenhydramine)
- Celebrex (celecoxib)
- Claritin (loratadine)
- CoQ10 (ubiquinone)
- Crestor (rosuvastatin)
- Cymbalta (duloxetine)
- Fish Oil (omega-3 polyunsaturated fatty acids)
- Lamictal (lamotrigine)
- Metoprolol Succinate ER (metoprolol)
- Probiotic Formula (bifidobacterium infantis / lactobacillus acidophilus)
- Prozac (fluoxetine)
- Singulair (montelukast)
- Synthroid (levothyroxine)
- Topamax (topiramate)
- Tylenol (acetaminophen)
- Vitamin B Complex 100 (multivitamin)
- Vitamin B12 (cyanocobalamin)
- Vitamin C (ascorbic acid)
- Vitamin D3 (cholecalciferol)
- Xanax (alprazolam)
- Zinc (zinc sulfate)
- Zyrtec (cetirizine)
Acetaminophen/aspirin/caffeine alcohol/food interactions
There are 6 alcohol/food interactions with acetaminophen / aspirin / caffeine.
Acetaminophen/aspirin/caffeine disease interactions
There are 21 disease interactions with acetaminophen / aspirin / caffeine which include:
- alcoholism
- liver disease
- coagulation
- cardiac disease
- hypertension
- psychiatric disorders
- PUD
- asthma
- GI toxicity
- renal dysfunction
- Reye's syndrome
- PKU
- cardiotoxicity
- liver disease
- renal dysfunction
- seizure disorders
- GERD
- anemia
- dialysis
- G-6-PD deficiency
- hepatotoxicity
Report options
More about acetaminophen / aspirin / caffeine
- acetaminophen/aspirin/caffeine consumer information
- Compare alternatives
- Pricing & coupons
- Reviews (388)
- Drug images
- Latest FDA alerts (4)
- Side effects
- Dosage information
- During pregnancy
- Drug class: analgesic combinations
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Qulipta
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Celebrex
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Verapamil
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Sumatriptan
Sumatriptan is a prescription medicine used to treat acute migraine headaches and cluster ...
Metoclopramide
Metoclopramide is used short-term to treat heartburn caused by gastroesophageal reflux. Learn about ...
Celecoxib
Celecoxib is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain or inflammation ...
Topiramate
Learn about topiramate, an anticonvulsant used for seizures, migraine prevention, and weight loss ...
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
