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User Reviews for 5-HTP

5-HTP has an average rating of 6.7 out of 10 from a total of 126 ratings on Drugs.com. 58% of reviewers reported a positive effect, while 22% reported a negative effect.

Condition Avg. Rating Reviews Compare
Anxiety  
6.8
109 reviews 54 medications
Insomnia  
5.9
14 reviews 106 medications
ADHD  
7.0
2 reviews 42 medications
Headache  
10.0
1 reviews 221 medications
Summary of 5-HTP reviews 6.7 126 reviews

Reviews may be edited to correct grammar/spelling, or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published.

Reviews for 5-HTP

Andres · Taken for less than 1 month May 3, 2020

For Anxiety: “Hi everyone, I hope that this message reaches out to as many people as possible. I suffered from anxiety for over 15 years. I tried everything possible, like EMDR, CBT, antidepressants (quite a few with no success as the anxiety was worse on medication than off). I came across this supplement 5-HTP a few days ago and it has changed my life radically! My anxiety was gone the same day I started taking it. Such a huge difference in outlook and interacting with people! I used to have SAD/GAD. Since I have been on this, nothing matters anymore. I do not think about the things I used to think about (e.g. getting anxiety for no reason, or being worried about how others perceive my accent). I do not care. I hope these meds continues to work and I will make sure to give you an update in a month. I wish you all the sufferers out there peace and fast recovery! Anxiety is awful!”

10 / 10
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Gannu · Taken for less than 1 month October 29, 2019

For Anxiety: “Yes it works. I am floating after taking 5-HTP. I take 100 mg after breakfast and 100 mg after dinner. Also I stopped smoking. Good for my anxiety and stress. In the past talking to people was hard. I am shy guy. I think too much, which is not at all required. After taking 5-HTP I feel the confidence . I am skinny guy and used to worry people around me is watching. Now I don’t care it’s my life and got my confidence now . I used to get tears automatically while talking to people because of nervousness. 5 HTP gave me my life back . Thanks”

10 / 10
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Shawn July 11, 2019

For Anxiety: “Took SSRI (Prozac) for Anxiety/Depression for 18 years with the only side effects being needing more sleep (8.5-9 hours a night minimum) than normal people. Four months ago, decided to quit the Prozac cold turkey because I thought I could manage without it. No issue initially, but couple months later I started getting very irritable and quite moody. Not wanting to go back to clinical drugs, decided to try 5-HTP. Taking slow time released 5-HTP 100mg twice a day. Two weeks in, the effects are undoubtable. The moodiness is under control, the 'overall feeling of well being' is back, sleep quality is much improved. Remember to take it with food. You might feel drowsy with mild headaches initially, this goes away in a week or so. Give it at least a couple weeks to fully kick in. Now, just hope the effects lasts long term and doesn't 'plateau' out. Maybe I'll make another post a year later, haha. Good luck!”

9 / 10
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Calepria · Taken for less than 1 month June 9, 2019

For Anxiety: “I have been suffering from severe panic disorder, depression, and anxiety for over a decade. I have tried different antidepressants and they only made it worse. I was at the lowest point I've ever been and I finally decided to give 5HTP a shot. I took 50mg yesterday afternoon, and another 50 mg before bed. I woke up this morning happy. I can't even describe how incredible that feels to me. Everything is normal now. I'm not afraid of people. I'm not afraid to go outside anymore. I no longer feel like I need to self-medicate with alcohol just to cope, and I am no longer suicidal. Everything is gone. But I'm still here. I highly recommend this, just to make sure you do your research or talk to a doctor.”

10 / 10
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NuttyFruitLoop · Taken for 10 years or more February 16, 2021

For Anxiety: “Be very mindful it's all about the dosage & type.. Always Always start with lowest dosage this is a very strong drug not to be messed about with.. 25-50mg is all that is needed to start with & use slow release to avoid bad side effects.I started this for PTSD, ADHD, depression, insomnia mood swings. I use 50mg slow release as soon as I open my eyes & if need be during stressful times another 50mg after lunch.. At 1st I did take the recommended dosages which in my experience are dangerous!!!. Horrendous side effects. Trial, error & masses of research was the key in the end. I have now been taking 5-HPT for 13yrs on & off due to PTSD & Undiagnosed ADHD Which was causing me all sorts of issues from Depression..Anxiety..Insomnia.. Terrible Mood Swings..Migraines the list goes on.. This stuff has helped tremendously with all the above.. I cannot rate it enough, actually saved my life :)”

10 / 10
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Sufferer of GAD + insomnia April 11, 2017

For Anxiety: “I have been troubled with severe generalised anxiety disorder (GAD) and social anxiety disorder for several years. I occasionally get panic attacks as well, and I struggle with insomnia. I have tried escitalopram, venlafaxine and sertraline in the past; and while they all helped a lot (specially the first 6 months) they did by no means take off more than 40-50% of the anxiety - max. I have been on 5-HTP for 1 week now. I am astonished of how well it works! I have absolutely no anxiety left! I feel completely normal... I don't have social anxiety, I don't even think or worry about issues that I usually always did and that has tormented me so long. Of course all this can be placebo, but I have tried many medications and no one can compare to this!”

10 / 10
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Shan · Taken for less than 1 month December 13, 2020

For Anxiety: “I have been taking 5-HTP for 1 week 100mg at night. I can tell you this works better than any other SSRI or SNRI that I have tried. The only side effect that I get is sometimes weird dreams. But the next morning after I take my dose I feel so good and I don't have much anxiety through out the day and I'm a lot happier as if the black cloud has been lifted. I struggle with anxiety and PTSD. For me this herb works better than prescription drugs and I'm thankful that Ive tried it!”

9 / 10
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Jiggs · Taken for less than 1 month October 1, 2018

For Anxiety: “Retired LEO ( Law Enforcement Officer) with PTSD & GAD. Have tried the Big Pharma route, assorted Tricylics, SSRI'S and many drugs that had names ending with "Pam". All had major side effects so gave them all up. Been drug free for over a decade but its been a daily battle with intrusive thoughts, mood swings, depression, over the top anxiety, lots of nightmares, flashbacks. Finally gave this a try. Started with 100mgs per day in conjunction with b complex vitamins. After a week, I must say that I'm feeling more grounded than I have in years. Even my wife has noticed a big difference. Going to increase it another 50mgs per day and we'll see how it goes from there.”

8 / 10
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autiem001 January 18, 2016

For Anxiety: “I am taking 5-htp (100MG) combined with a complex B vitamin (100MG) and Sam-e 200MG everyday.. IT WORKS.. I am taking these three to treat depression and anxiety. I did not want to be on an anti depressant. My mood is lighter, I feel happier and I feel OKAY. I feel into a deep depression and felt very hopeless and these, along with counselling, are helping me through it. I am blown away by the effectiveness of these three supplements together. I highly recommend them. I can sleep just fine and I don't feel like there is a rain cloud over my head anymore. I've been waiting to see the sun shine through my heart (sounds cheese lol) but it's true! AND I FEEL IT! I hope you can too.”

10 / 10
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Jobella April 13, 2016

For Anxiety: “For years I silently suffered from depression and bouts of anxiety. I just though this is who I am and accept it. I tried anti depressants only a couple times on and off again when I felt desperate or overwhelmed only too make me feel even worse. I was extremely tired all the time, pissed off at everything, became less social, eating more, and just never feeling a day of happiness without really trying. Until 5-HTP. For me it has worked wonders in just 24 hours of many years of not feeling right. I wake up and feel good! I am not tired one bit. I feel human again. Like someone gave me my life back as an unexpected gift. Never did I think it would help or work as amazing as It does and I feel. No side effects.”

10 / 10
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Kelleyp83 · Taken for 1 to 6 months July 17, 2016

For Anxiety: “I started taking 300 mg/day about a month ago, and it has drastically changed my quality of life (though it did not happen in one day for me, as other people have noted). I've been on a series of antidepressants over the last 5-6 years, but could never reconcile the side effects with the minimal improvements I got from the medications. Over the past 2-3 weeks, I've stopped the daily crying jags I was experiencing before, and I actually feel like I'm in a good mood a couple times a week. Even my child has commented that I'm more fun.”

9 / 10
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BASIL48 April 13, 2020

For Anxiety: “Have had anxiety for as long as I can remember. Always nervous and in a fearful state. Facing my fears did not help.The only relieve I got from anxiety was when I exercised and afterwards for couples of hours. I had a gut feeling it was a chemical balance and tried numerous natural aids, some helped a little. Then I tried 5 htp 100 mg and my anxiety was gone. I take 50 mg 3 times per day. As someone who was using benzos on and off for15 years I tapered off using niacinamide and l theanine then finally came across 5 htp. 5 HTP is better than benzos for me. Better mood and no anxiety.”

9 / 10
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Revelation in a bottle. March 19, 2013

For Anxiety: “After years of trying supplements that had no appreciable effect and being adamantly opposed to taking antidepressants after researching them, I'd given up on feeling "good" and tried to accept my anxious, depressed, miserable, irritable state as my personality. But, on a whim, I gave 5-HTP a shot. And... just wow. WOW. No placebo, no question, no nonsense. 5-HTP has a very strong, STRONG positive effect on me. My mind feels cushioned and clear, my anxieties fade away, and I feel just... collected, calm, comfortable, positive, eager to laugh. It's like night and day off and on. And again, 5-HTP hits hard and immediately, but with no side effects aside from mild gastrointestinal distress.”

9 / 10
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joruby · Taken for 6 months to 1 year April 18, 2016

For Anxiety: “5 htp worked straight away for me after been recommended by a friend .after losing my father suddenly , I found I was no longer normal felt so lost .unhappy .not sleeping .tearful .nothing in life made me happy .tried the doctors .they wanted to give me anti depression tablets .I did not want to go there .so I went shopping bumped into a friend .she recommend 5-htp.so the same day went and got them .haven't looked back since.that was 11 months ago .thamk you to 5htp”

10 / 10
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Bigkev · Taken for less than 1 month August 28, 2019

For Anxiety: “I was reluctant to try this at first but after a failed attempt at getting relief from depression and anxiety with , I almost lost all hope. I saw a reference to it on the website for recovering addicts, and me being a recovering opioid addict ,realized that maybe it might help my serotonin levels go back up . I’ve also been taking suboxone for approx 2 years. Really am convince that this stuff 5HTP does work! I’m very aware of placebo effects of taking something . I feel clearer mentally and overall more like someone pulled the shades open!”

8 / 10
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Duhka May 1, 2016

For Anxiety: “I just started taking it.The results have so far been fantastic.I take 100 mgs./4 times a day. The depression has lifted and I have more energy.I think you have to be careful with it. Do a lot of reading and monitor yourself--keep a journal.I will take it for one month;see How I do and then maybe back off a bit.I have suffered severe depression my entire adult Life,I hope this is finally the miracle I have been praying for.”

9 / 10
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Kate M. November 29, 2013

For Anxiety: “I have always suffered from mild mood disorder, general anxiety, stress-induced panic attacks, mixed with ups and downs. My chiropractor mentioned L-5-HTP, so I gave it a try. Within 48 hours, I was feeling a night & day difference. Since I discovered this supplement, I take it in a cycle of a few months on and then a month off. I find that my body builds a tolerance after awhile, and I will stop and restart again with no side effects in the meantime. After taking L-5-HTP, I feel happy, calm, and my life is in perspective. Make sure you purchase the L-5-HTP, not just cheap HTP. The L-tryptophan is the active ingredient on a molecular level, with vitamin C to help your body absorb the supplement.”

9 / 10
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A November 15, 2019

For Anxiety: “Wanted to share my experience with 5-HTP in case it helped anyone. I've used 50mg once daily for the past few years to help with depression/anxiety/sleep issues and it did help for a while, especially with sleeping better. Unfortunately, I now have to stop after realizing it has been making symptoms worse after taking it probably too long. Too much serotonin in your system will cause worse anxiety, so just know that just because this product is sold in the health food section - I would definitely consider it a natural drug you should do your research on. If the dose is too high it will cause worse anxiety issues. This drug can also interact with other medications and alcohol, so just be aware. Buy a brand with good reviews and figure out what time of day taking it works best for you. It made me a bit too relaxed to take it in the morning, but taking it right before bed caused crazy dreams - so taking it with dinner at least a few hours before bed worked best for me personally.”

7 / 10
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TKahler · Taken for less than 1 month June 16, 2019

For Anxiety: “I was at Walgreen's buying some Melatonin to help me sleep and I just happened to see the bottle of 5 HTP in the same section advertising anti-anxiety properties. I was skeptical but decided that it was worth the 20 bucks to see if it would help alleviate my anxiety issues. I was teaching a class that night and took one of the 5 HTP pills (50 mg) and kind of forgot about it. Several hours had passed and I was on my way home from said class and realized I felt pretty good and relaxed and then remembered the pill I had taken. I was still skeptical however and decided to try another one the next day and I got the same feeling. It's not a tired or groggy feeling, it's actual relief from anxiety and it really works. The only drawback is it can cause your stomach to churn a bit when you first start taking them so make sure you take them with food.”

9 / 10
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JohnG89 December 25, 2016

For Anxiety: “5-HTP HAS CHANGED MY LIFE!!! I'm 27 and have suffered from chronic depression since I was 13. Have attempted to take my life several times and by age 17 I took to drugs to get away from my depression. I spent years searching for a substance/experience to help me feel "normal" Once I got clean the depression came back worse than ever. I tried several meds cymbalta/prozac/effecxor and they all made me worse or no effect. Once I started 5-htp I started to feel better within 3 days. I play around between 100-300mg and they just work like magic for me. I feel totally normal on them I buy mine off internet and I can honestly say I have suffered no side effects whatsoever other than very vivid dreams. I would highly recommend everyone to try.”

10 / 10
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Helen March 13, 2019

For Anxiety: “I have been suffering with anxiety & depression for 16 years. 10 years ago I took Zoloft & had therapy for a few years but have been on my own with it for 6 years. Recently it was getting hard to deal with again. I tried some herbal routes and St. John’s wort & ashwagandha make me manic. A few months ago someone suggested 5-htp which I eventually went out & got some. Game changer. I’m small (4’10” 95lbs) so I take 50mg every other day- or every three days. If I’m still experiencing a mildly uplifting mood or lack of intrusive thoughts I just keep going without taking another pill. It’s been super helpful & I never thought I’d be able to live like this. This is the first relief I have found that actually feels healthy & not that I’m just masking part of my sensitivity.”

10 / 10
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Anonomous · Taken for less than 1 month May 28, 2020

For Anxiety: “I came off my anti depressants about 6 months ago with medical supervison, and decided to try 5 HTP about a month after. I got the impression it made me a lot more anxious and a bit paranoid so I stopped using it after a couple of weeks and wondered if it was too close to coming off my medication. Six months later I thought I would give it another go, it has been 4 days since I started and today I feel much more anxious and paranoid again. I think 5 HTP works well for some people but for others it makes anxiety worse.”

1 / 10
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T G · Taken for less than 1 month July 1, 2019

For Anxiety: “33 year old male. Started having nocturnal anxiety attacks. Happened for a couple weeks. Would wake up after falling asleep (usually with a late meal) not being able to breath, chest pain, feeling heavy, and weak. I actually went to the ER the first night it happened because I thought I was dying. Doctor originally thought the issue was caused by stomach acid getting into lungs but antacids did nothing. Doctor then suggested 5 HTP a week later. No more attacks (other than the one night I forgot to take the pill) after I started taking 100mg before bed. If you plan on taking 5HTP, get quality product (don’t go cheap trying to save a dollar). Some of the lower quality stuff can have its own side effects. Good luck.”

10 / 10
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Earthmumma October 18, 2016

For Anxiety: “I suffer from depression, anxiety, ptsd, panic attacks, insomnia & migraines. I prefer holistic treatments so after some research tried 5HTP. All my "issues" have either improved massively or disappeared completely. I take 100mg time release each morning. In times of extra stress I take another 100mg at night just to stay on top of everything. Note: Your body needs a break from 5HTP every now & then or it will become used it & not be as effective. I usually take it for 3 months then take a 1 to 2 month break (during which I supplement with St John's Wort if I find I'm having any "head space" or stress issues). IMPORTANT: Check with dr if you are already on antiD meds as it can interract with some nasty side effects.”

10 / 10
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Tina Byrd · Taken for 1 to 6 months April 13, 2016

For Anxiety: “I have suffered from social/generalized anxiety for as long as I can remember, it got really bad as I entered puberty and I think I went out a maximum of 10 times my entire high school career. I also suffer from depression and when I went on the depo birth control shot both mental illness were the worst they have ever been, even my husband became concerned and spent hours a day researching ways to get me up and about again. I would spend my entire day in bed and the shot also caused me to gain 30lbs which distroyed any self esteem I had left. A customer and friend suggested 5-htp and I'm never looking back! I can enjoy life again, I can feel and I'm not having anxiety attacks from leaving my house any more. I've also lost 10lbs. It works!”

7 / 10
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This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare professionals.

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