Generic Name: omeprazole/sodium bicarbonate (oh-MEP-ra-zole/SOE-dee-um bye-KAR-bo-nate)
Brand Name: Examples include Zegerid and Zegerid OTC
Zegerid OTC is used for:
Treating heartburn or irritation of the esophagus caused by gastroesophageal reflux disease (GERD). It may also be used for short-term treatment of ulcers of the stomach or small intestine. It may also be used to decrease the risk of stomach bleeding in severely ill patients. It may also be used for other conditions as determined by your doctor.
Zegerid OTC is a proton pump inhibitor (PPI) and sodium bicarbonate combination. The PPI works by decreasing the amount of acid produced in the stomach. The sodium bicarbonate works by slowing the breakdown of the PPI in the stomach, which helps to increase absorption of the PPI.
Do NOT use Zegerid OTC if:
- you are allergic to any ingredient in Zegerid OTC or to any other PPI (eg, esomeprazole)
- you have low blood calcium levels or metabolic alkalosis
- you are taking atazanavir, clopidogrel, dasatinib, nelfinavir, rifampin, rilpivirine, or St. John's wort
Contact your doctor or health care provider right away if any of these apply to you.
Before using Zegerid OTC:
Some medical conditions may interact with Zegerid OTC. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have trouble or pain swallowing food; black, tarry, or bloody stools; or vomit that looks like blood or coffee grounds
- if you have had heartburn for more than 3 months
- if you have heartburn with light-headedness, sweating, or dizziness
- if you have frequent chest pain, frequent wheezing (especially with heartburn), unexplained weight loss, nausea or vomiting, or stomach pain
- if you have chest or shoulder pain with shortness of breath; sweating; pain spreading to the arms, neck, or shoulders; or light-headedness
- if you are on a low-salt (sodium) diet
- if you have liver problems, heart failure, stomach or bowel cancer, or undiagnosed bleeding from the rectum
- if you have Bartter syndrome; low blood potassium, calcium, or magnesium levels; low blood vitamin B12 levels or vitamin B12 deficiency; acid-base balance problems; or respiratory alkalosis
- if you have osteoporosis (weak bones), a family history of osteoporosis, or other risk factors for osteoporosis (eg, smoking, poor nutrition)
Some MEDICINES MAY INTERACT with Zegerid OTC. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Diuretics (eg, furosemide, hydrochlorothiazide) because the risk of low blood magnesium levels may be increased
- Voriconazole because it may increase the risk of Zegerid OTC's side effects
- Ginkgo biloba, rifampin, or St. John's wort because they may decrease Zegerid OTC's effectiveness
- Anticoagulants (eg, warfarin), benzodiazepines (eg, diazepam), cilostazol, citalopram, cyclosporine, digoxin, disulfiram, escitalopram, hydantoins (eg, phenytoin), methotrexate, saquinavir, or tacrolimus because the risk of their side effects may be increased by Zegerid OTC
- Ampicillin, atazanavir, bosutinib, clopidogrel, dasatinib, erlotinib, indinavir, iron, itraconazole, ketoconazole, mycophenolate, nelfinavir, nilotinib, posaconazole, rilpivirine, or sorafenib because their effectiveness may be decreased by Zegerid OTC
This may not be a complete list of all interactions that may occur. Ask your health care provider if Zegerid OTC may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Zegerid OTC:
Use Zegerid OTC as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Zegerid OTC comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Zegerid OTC refilled.
- Take Zegerid OTC by mouth on an empty stomach at least 1 hour before a meal.
- Take Zegerid OTC with a full glass of water (8 oz [240 mL]). Do not take Zegerid OTC with other liquids.
- Swallow Zegerid OTC whole. Do not break, crush, or chew before swallowing. Do not open the capsule and sprinkle the contents on food.
- You may take antacids while you are using Zegerid OTC if you are directed to do so by your doctor.
- If you miss a dose of Zegerid OTC, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Zegerid OTC.
Important safety information:
- Zegerid OTC may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Zegerid OTC with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Contact your doctor if you have any signs of a bleeding ulcer, such as black, tarry stools or vomit that looks like coffee grounds, or if you experience throat pain, chest pain, severe stomach pain, or trouble swallowing.
- Do NOT change your dose, stop taking Zegerid OTC, or take Zegerid OTC for longer than prescribed without checking with your doctor.
- Zegerid OTC may increase the risk of a serious form of diarrhea. Contact your doctor right away if stomach pain or cramps, severe or persistent diarrhea, or bloody or watery stools occur. Discuss any questions or concerns with your doctor.
- Zegerid OTC may increase the risk of hip, wrist, and spine fractures in patients with weak bones (osteoporosis). The risk may be greater if you use Zegerid OTC in high doses, for longer than a year, or if you are older than 50 years old. Contact your doctor if you have any questions about this information.
- Low blood magnesium levels have been reported rarely in patients taking PPIs for at least 3 months. In most cases, this effect was seen after a year of treatment. If you will be taking Zegerid OTC for a long time, or if you take certain other medicines (eg, digoxin, diuretics), your doctor may perform lab tests to check for low blood magnesium levels. Seek medical attention right away if you experience symptoms of low blood magnesium levels (eg, dizziness; fast or irregular heartbeat; involuntary muscle movements; jitteriness or tremors; muscle aches, cramps, pain, spasms, or weakness; seizures).
- Long-term treatment (eg, longer than 3 years) with medicines like this one has rarely caused low vitamin B12 levels. Discuss any questions or concerns with your doctor.
- Check with your doctor to see whether you should take a calcium and vitamin D supplement while you use Zegerid OTC.
- Certain brands of Zegerid OTC may only be taken for a 14-day course once every 4 months unless your doctor tells you otherwise. Contact your doctor if you have any questions about this information.
- Zegerid OTC has sodium in it. Include this when you count your daily intake of sodium.
- Long-term use of Zegerid OTC with calcium or milk may cause milk-alkali syndrome. Check with your doctor before you take calcium supplements or antacids that contain calcium or drink milk while you are taking Zegerid OTC.
- Both strengths of Zegerid OTC contain the same amount of sodium bicarbonate. Therefore, if your doctor has prescribed the 40 mg dose, do not take 2 of the 20 mg capsules to make a 40 mg dose.
- Zegerid OTC may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking Zegerid OTC.
- Zegerid OTC should be used with extreme caution in Asian patients; the risk of side effects may be increased in these patients.
- Use Zegerid OTC with caution in the ELDERLY; they may be more sensitive to its effects, especially hip, wrist, and spine fractures.
- PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Zegerid OTC while you are pregnant. Zegerid OTC is found in breast milk. Do not breast-feed while taking Zegerid OTC.
Possible side effects of Zegerid OTC:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Gas; headache; mild diarrhea or stomach pain; nausea; vomiting.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest or throat; swelling of the mouth, face, lips, or tongue; unusual hoarseness); bloody or watery stools; bone pain; chest pain; confusion; dark urine; dizziness; fast, slow, or irregular heartbeat; fever, chills, or sore throat; hand tremors; muscle twitching; numbness or tingling in the face, arms, or legs; red, swollen, blistered, or peeling skin; seizures; severe or persistent diarrhea or stomach pain; severe or persistent nausea or vomiting; stomach cramps; swelling of the hands, ankles, or feet; symptoms of kidney problems (eg, not able to pass urine, change in the amount of urine produced, blood in the urine, a big weight gain); unexplained weight loss; unusual bruising or bleeding; unusual or sudden weight increase; unusual tiredness; vision changes; yellowing of the eyes or skin.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.Proper storage of Zegerid OTC:
Store Zegerid OTC at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Zegerid OTC out of the reach of children and away from pets.
- If you have any questions about Zegerid OTC, please talk with your doctor, pharmacist, or other health care provider.
- Zegerid OTC is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take Zegerid OTC or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Zegerid OTC. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Zegerid OTC. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Zegerid OTC.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.
More about Zegerid OTC (omeprazole / sodium bicarbonate)
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
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- Drug class: proton pump inhibitors