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Omeprazole and sodium bicarbonate

Generic Name: omeprazole and sodium bicarbonate (oh ME pray zol and SO dee um by KAR bon ate)
Brand Name: Zegerid, Zegerid OTC

Medically reviewed by Drugs.com on Jun 26, 2018 – Written by Cerner Multum

What is omeprazole and sodium bicarbonate?

Omeprazole is a proton pump inhibitor that decreases the amount of acid your stomach produces. Sodium bicarbonate is an antacid that raises the pH in your stomach to keep the omeprazole from breaking down in stomach acid.

Omeprazole and sodium bicarbonate is a combination medicine used to treat heartburn and other symptoms of gastroesophageal reflux disease (GERD). omeprazole and sodium bicarbonate is also used to treat ulcers and other conditions involving excessive stomach acid production.

Omeprazole and sodium bicarbonate is not for immediate relief of heartburn symptoms.

Omeprazole and sodium bicarbonate may also be used for purposes not listed in this medication guide.

Important Information

Omeprazole can cause kidney problems. Tell your doctor if you are urinating less than usual, or if you have blood in your urine.

Diarrhea may be a sign of a new infection. Call your doctor if you have diarrhea that is watery or has blood in it.

Omeprazole may cause new or worsening symptoms of lupus. Tell your doctor if you have joint pain and a skin rash on your cheeks or arms that worsens in sunlight.

You may be more likely to have a broken bone while taking this medicine long term or more than once per day.

This medicine contains sodium bicarbonate, a form of salt. Tell your doctor if you have Bartter's syndrome (a rare kidney disorder), or if you are on a low-salt diet.

Before taking this medicine

Heartburn can mimic early symptoms of a heart attack. Get emergency medical help if you have chest pain that spreads to your jaw or shoulder and you feel anxious or light-headed.

You should not take omeprazole and sodium bicarbonate if you are allergic to omeprazole or sodium bicarbonate.

This medicine contains sodium bicarbonate, a form of salt. Each capsule contains the equivalent of 300 mg of sodium. Each packet of powder contains the equivalent of 460 mg of sodium. If you are on a low-sodium diet, you may not be able to use omeprazole and sodium bicarbonate. Talk with your doctor.

Ask a doctor or pharmacist if this medicine is safe to use if you have:

  • a rare kidney disorder called Bartter's syndrome;

  • liver disease;

  • any allergies;

  • heart problems; or

  • low levels of calcium, magnesium, or potassium levels in your blood.

You may be more likely to have a broken bone in your hip, wrist, or spine while taking a proton pump inhibitor long-term or more than once per day. Talk with your doctor about ways to keep your bones healthy.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

You should not breast-feed while using this medicine.

Omeprazole and sodium bicarbonate is not approved for use by anyone younger than 18 years old.

How should I take omeprazole and sodium bicarbonate?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Take this medicine on an empty stomach, at least 1 hour before eating a meal. If this medicine is given to a person who is fed through a nasogastric (NG) tube, the feeding should be stopped at least 3 hours before giving the medicine. Do not restart nasogastric feeding for at least 1 hour after giving omeprazole and sodium bicarbonate.

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.

Take the omeprazole and sodium bicarbonate capsule with a full glass of water. Do not use any other type of liquid or food.

Swallow the capsule whole and do not crush, chew, break, or open it.

Do not use two 20-mg capsules to equal one 40-mg capsule. Do not use two 20-mg powder packets to equal one 40-mg powder packet. If you do not use the exact capsule or powder packet your doctor has prescribed, you may receive too much sodium bicarbonate.

To use the powder form, open a packet and pour all of the powder into a small cup with 1 or 2 tablespoons of water. Do not use any other type of liquid. Stir and drink this mixture right away. Add a little more water to the glass, swirl gently and drink right away.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Use the medicine as soon as you can, but skip the missed dose if your next dose is due in less than 12 hours. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include confusion, drowsiness, dry mouth, blurred vision, fast heartbeats, sweating, vomiting, and warmth or tingling.

What should I avoid while taking omeprazole and sodium bicarbonate?

omeprazole and sodium bicarbonate can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor before using anti-diarrhea medicine.

Omeprazole and sodium bicarbonate side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • severe stomach pain, diarrhea that is watery or bloody;

  • new or unusual pain in your wrist, back, hip, or thigh;

  • stomach pain, nausea, vomiting, weight loss;

  • confusion, dizziness, seizure (convulsions);

  • numbness or tingling in your face, arms, or legs;

  • kidney problems--little or no urination, blood in your urine, swelling, rapid weight gain;

  • low magnesium--dizziness, fast or irregular heart rate, tremors (shaking) or jerking muscle movements, feeling jittery, muscle cramps, muscle spasms in your hands and feet, cough or choking feeling; or

  • new or worsening symptoms of lupus--joint pain, and a skin rash on your cheeks or arms that worsens in sunlight.

Taking this medicine long-term may cause you to develop stomach growths called fundic gland polyps. Talk with your doctor about this risk.

If you use omeprazole and sodium bicarbonate for longer than 3 years, you could develop a vitamin B-12 deficiency. Talk to your doctor about how to manage this condition if you develop it.

Common side effects may include:

  • headache;

  • nausea, vomiting, stomach pain, gas; or

  • diarrhea.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Omeprazole and sodium bicarbonate dosing information

Usual Adult Dose for Duodenal Ulcer:

Omeprazole 20 mg orally once a day
-Duration of therapy: 4 weeks

Comment: If patients are not healed after 4 weeks, treatment for another 4 weeks may be considered.

Use: Short-term treatment of active duodenal ulcer

Usual Adult Dose for Gastric Ulcer:

Omeprazole 40 mg orally once a day
-Duration of therapy: 4 to 8 weeks

Use: Short-term treatment of active benign gastric ulcer

Usual Adult Dose for Gastroesophageal Reflux Disease:

Omeprazole 20 mg orally once a day
-Duration of therapy: Up to 14 days (Over-the-Counter [OTC] formulations); Up to 4 weeks (prescription formulations)

Comments:
-The OTC formulation course of treatment may be repeated every 4 months as necessary.
-The full effect of treatment may not be reached for up to 4 days.

Uses:
-Treatment of symptomatic gastroesophageal reflux disease (GERD) without esophageal erosions (prescription formulations)
-Treatment of frequent heartburn occurring at least 2 days a week (OTC formulations)

Usual Adult Dose for Erosive Esophagitis:

Treatment: Omeprazole 20 mg orally once a day
-Duration of therapy: 4 to 8 weeks

Maintenance: Omeprazole 20 mg orally once a day

Comments:
Controlled studies for the efficacy in treatment of erosive esophagitis did not extend beyond 8 weeks.
-An additional 4 to 8-week course of therapy may be considered in patients with a recurrence of erosive esophagitis or GERD symptoms after initial treatment.
-Controlled studies for maintenance therapy did not extend beyond 12 months.

Uses:
-Short-term treatment of erosive esophagitis diagnosed by endoscopy
-Maintenance of healing of erosive esophagitis

Usual Adult Dose for Gastrointestinal Hemorrhage:

Oral suspension: Omeprazole 40 mg orally, followed by 40 mg 6 to 8 hours later, and 40 mg orally once a day thereafter
-Duration of therapy: 14 days

Comment: Controlled studies did not extend past 12 months.

Use: Reduction of risk of upper gastrointestinal bleeding in critically ill patients

What other drugs will affect omeprazole and sodium bicarbonate?

Tell your doctor about all your current medicines. Many drugs can affect omeprazole and sodium bicarbonate, especially:

This list is not complete and many other drugs may affect omeprazole and sodium bicarbonate. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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