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Omeprazole / Sodium Bicarbonate Dosage

Applies to the following strength(s): 20 mg-1100 mg ; 40 mg-1100 mg ; 20 mg-1680 mg ; 40 mg-1680 mg

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Duodenal Ulcer

Recommended dose: 20 mg orally once a day
Duration of therapy: 4 weeks

Comment:
-If patients are not healed after 4 weeks, treatment for another 4 weeks may be considered.

Use: Short-term treatment of active duodenal ulcer

Usual Adult Dose for Gastric Ulcer

Recommended dose: 40 mg orally once a day
Duration of therapy: 4 to 8 weeks

Use: Short-term treatment of active benign gastric ulcer

Usual Adult Dose for Gastroesophageal Reflux Disease

Recommended dose: 20 mg orally once a day
Duration of therapy: Up to 14 days (Over-the-Counter [OTC] formulations) and up to 4 weeks (prescription formulations)

Comments:
-The OTC formulation course of treatment may be repeated every 4 months as necessary.
-The full effect of treatment may not be reached for up to 4 days.

Uses:
-Treatment of symptomatic gastroesophageal reflux disease (GERD) without esophageal erosions
-Treatment of frequent heartburn occurring at least 2 days a week

Usual Adult Dose for Erosive Esophagitis

Treatment:
-Recommended dose: 20 mg orally once a day
-Duration of therapy: 4 to 8 weeks

Maintenance:
-Recommended dose: 20 mg orally once a day

Comment:
-Controlled studies for maintenance therapy did not extend beyond 12 months.

Uses:
-Treatment of erosive esophagitis
-Maintenance of healing of erosive esophagitis

Usual Adult Dose for Gastrointestinal Hemorrhage

ORAL SUSPENSION:
-Recommended dose: 40 mg orally, followed by 40 mg 6 to 8 hours later, and 40 mg orally once a day thereafter
-Duration of therapy: 14 days

Comment:
-Controlled studies did not extend past 12 months.

Use: Reduction of risk of upper gastrointestinal bleeding in critically ill patients

Renal Dose Adjustments

No adjustment recommended.

Liver Dose Adjustments

Dose reductions should be considered, especially when used to maintain healing of erosive esophagitis:

Dose Adjustments

Asian patients: Dose reductions should be considered, especially when used to maintain healing of erosive esophagitis.

Precautions

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:
-This drug should be taken on an empty stomach at least 1 hour before a meal. The capsule should be swallowed whole, without chewing or crushing; patients should not open the capsule and sprinkle the contents into food or other liquids.
-Patients receiving continuous nasogastric/orogastric tube feeding should stop feeding 3 hours before and 1 hour after taking this drug.

Reconstitution/preparation techniques:
-The manufacturer product information should be consulted.

Storage requirements:
-The manufacturer product information should be consulted.

General:
-The dose of sodium bicarbonate is the same in the 20 and 40 mg formulations; thus, two 20 mg capsules/packets are not equivalent to a single 40 mg capsule/packet. The manufacturer product information should be consulted for more information on sodium content.

Monitoring:
-Magnesium levels, especially in patients taking other drugs that could result in hypomagnesemia or those on long-term therapy
-Vitamin B12 levels, especially in patients on long-term therapy
-Bone fractures, especially in patients at high-risk for osteoporosis-related events

Patient advice:
-Patients should be advised that use is not intended for immediate relief. Patients may not experience full effects for up to 4 days.
-If using this drug to treat H pylori, tell patients that it is important to complete the full regimen.
-Instruct patients to seek medical attention if signs/symptoms of hypersensitivity, Clostridium difficile, or systemic cutaneous lupus erythematosus occur.
-Inform patients that this drug may cause drowsiness, dizziness, vertigo, and/or visual disturbances. They should avoid driving or operating machinery until the full effects of the drug are seen.
-Advise patients to speak to their healthcare provider if they become pregnant, intend to become pregnant, or are breastfeeding.

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