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Secukinumab

Generic Name: secukinumab (SEK-ue-KIN-ue-mab)
Brand Name: Cosentyx

Secukinumab is used for:

Treating moderate to severe plaque psoriasis in certain patients. It may also be used for other conditions as determined by your doctor.

Secukinumab is a monoclonal antibody. It works by blocking certain substances in the body that affect inflammation and the body's immune system.

Do NOT use secukinumab if:

  • you are allergic to any ingredient in secukinumab

Contact your doctor or health care provider right away if any of these apply to you.

Before using secukinumab:

Some medical conditions may interact with secukinumab. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances, including rubber or latex
  • if you have a history of an infection that does not go away, an infection that keeps coming back, tuberculosis (TB) infection, or positive TB skin test
  • if you have recently received a vaccine or you are scheduled to receive a vaccine
  • if you have Crohn disease
  • if you have open cuts or sores on your body, you have flu-like symptoms or other signs of infection (eg, fever; chills; cough; warm, red, or painful skin), or are using medicine to treat an infection
  • if you have ever lived in or traveled to an area where TB is common, or if you have come into close contact with a person with active TB

Some MEDICINES MAY INTERACT with secukinumab. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Cyclosporine or warfarin because the risk of their side effects may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if secukinumab may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use secukinumab:

Use secukinumab as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Secukinumab comes with an extra patient information sheet called a Medication Guide. It also comes with an extra patient leaflet with detailed instructions for use. Read them carefully. Read them again each time you get secukinumab refilled. Ask your doctor, nurse, or pharmacist any questions that you may have about this information.
  • Secukinumab is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using secukinumab at home, a health care provider will teach you how to use it. Be sure you understand how to use secukinumab. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
  • Use the proper technique taught to you by your doctor. Inject deep under the skin, NOT into muscle or a vein.
  • Injection sites within an injection area (stomach area or thighs; outer area of the upper arm if someone else is giving you secukinumab) must be rotated from one injection to the next. Do not inject secukinumab within 2 inches of the belly button. Do not inject secukinumab into an area that is irritated, bruised, red, hard, infected, scarred, or has stretch marks.
  • Before using secukinumab, take it out of the refrigerator. Allow to reach room temperature (15 to 30 minutes) without taking off the needle cap. Do not heat secukinumab.
  • Do not shake secukinumab. Secukinumab is colorless to light yellow. Do not use secukinumab if it contains particles, is cloudy or discolored, or if the pen or syringe is cracked or damaged.
  • Use secukinumab within 1 hour after taking out of the refrigerator. After you use secukinumab, throw away any medicine left in the pen or syringe.
  • Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
  • If you miss a dose of secukinumab, call your doctor to find out what do.

Ask your health care provider any questions you may have about how to use secukinumab.

Important safety information:

  • Tell your doctor or dentist that you take secukinumab before you receive any medical or dental care, emergency care, or surgery.
  • Patients should receive a TB skin test before using secukinumab. Patients who test positive for TB should begin treatment for TB before starting secukinumab. All patients should also be monitored for signs of TB while using secukinumab even if their TB test is negative.
  • Secukinumab may lower the ability of your body to fight infection and increase your risk of infections. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.
  • Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.
  • If you have Crohn disease, talk with your doctor. Worsening of Crohn disease can happen with secukinumab. Sometimes this may be serious. Discuss any questions or concerns with your doctor.
  • Make sure you are up to date with all your vaccines.
  • Do not receive a live vaccine (eg, measles, mumps) while you are taking secukinumab. Talk with your doctor before you receive any vaccine.
  • Lab tests, including TB tests, may be performed while you use secukinumab. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using secukinumab while you are pregnant. It is unknown if secukinumab is found in breast milk. If you are or will be breast-feeding while you use secukinumab, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of secukinumab:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Cold symptoms; diarrhea; nose or throat irritation; symptoms of upper respiratory infection (eg, mild cough, runny or stuffy nose, sneezing, mild sore throat).

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; feeling faint; tightness in the chest or throat; swelling of the mouth, face, lips, throat, or tongue); symptoms of infection (eg, fever, sweats, chills, or persistent sore throat; cough; muscle aches; shortness of breath; warm, red, or painful skin or sores on your body; increased or painful urination; stomach pain or diarrhea; blood in phlegm; unexplained weight loss).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of secukinumab:

Store secukinumab in the refrigerator, between 36 and 46 degrees F (2 and 8 degrees C). Do not freeze. Store in the original carton to protect from light. Keep secukinumab out of the reach of children and away from pets.

General information:

  • If you have any questions about secukinumab, please talk with your doctor, pharmacist, or other health care provider.
  • Secukinumab is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take secukinumab or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about secukinumab. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to secukinumab. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your health care provider for complete information about the risks and benefits of using secukinumab.

Review Date: August 8, 2016

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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