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Generic Name: Buprenorphine Implant (byoo pre NOR feen)
Brand Name: Probuphine

Medically reviewed by Last updated on Jul 12, 2019.


  • This medicine may cause very bad and sometimes deadly breathing problems. Call your doctor right away if you have slow, shallow, or trouble breathing.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • This medicine has an opioid drug in it. The use of opioid drugs along with a benzodiazepine drug or other drugs that may make you drowsy or slow your actions has led to very bad side effects. Side effects that have happened include slowed or trouble breathing and deaths. Benzodiazepine drugs include drugs like alprazolam, diazepam, and lorazepam. Benzodiazepine drugs are used to treat many health problems like anxiety, trouble sleeping, or seizures. Talk with the doctor.
  • Many drugs interact with Probuphine (buprenorphine implant) and can raise the chance of side effects like deadly breathing problems. Talk with your doctor and pharmacist to make sure it is safe to use Probuphine (buprenorphine implant) with all of your drugs.
  • Do not take with alcohol or products that have alcohol. Unsafe and sometimes deadly effects may happen.
  • Get medical help right away if you feel very sleepy, very dizzy, or if you pass out. Caregivers or others need to get medical help right away if the patient does not respond, does not answer or react like normal, or will not wake up.
  • Using Probuphine (buprenorphine implant) for a long time during pregnancy may lead to withdrawal in the newborn baby. This can be life-threatening. Talk with the doctor.
  • Very bad problems can happen when Probuphine (buprenorphine implant) is put in or taken out. These include the implant moving, sticking out of the skin, or coming out by itself. This may cause nerve or blood vessel injury in the arm. It could be deadly if the implant or pieces of it move into the blood vessels or your lungs. Call your doctor right away if the implant sticks out of the skin or comes out by itself. Call your doctor right away if you have numbness or weakness in your arm, chest pain, or shortness of breath.
  • It is common to have itching, pain, irritation, redness, swelling, scarring, bleeding, or bruising where the implant is put in or taken out. Call the doctor if you have bleeding, or if any of these effects happen often or get worse.

Uses of Probuphine:

  • It is used to treat pain drug (opioid) addiction.
  • This medicine is only for use by people who have been taking pain drugs (opioids) and are used to their effects. Talk with the doctor.

What do I need to tell my doctor BEFORE I take Probuphine?

  • If you have an allergy to buprenorphine or any other part of Probuphine (buprenorphine implant).
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you have any of these health problems: Lung or breathing problems like asthma, trouble breathing, or sleep apnea; high levels of carbon dioxide in the blood; or stomach or bowel block or narrowing.
  • If you have liver disease.
  • If you or a family member have a long QT on ECG.
  • If you are taking any of these drugs: Butorphanol, nalbuphine, or pentazocine.
  • If you are using another drug that has the same drug in it.
  • If you are taking any of these drugs: Certain drugs to treat a heartbeat that is not normal like amiodarone, disopyramide, dofetilide, procainamide, quinidine, or sotalol.
  • If you are taking any drugs that can cause a certain type of heartbeat that is not normal (prolonged QT interval). There are many drugs that can do this. Ask your doctor or pharmacist if you are not sure.
  • If you have taken certain drugs for depression or Parkinson's disease in the last 14 days. This includes isocarboxazid, phenelzine, tranylcypromine, selegiline, or rasagiline. Very high blood pressure may happen.
  • If you are taking any of these drugs: Linezolid or methylene blue.

This is not a list of all drugs or health problems that interact with Probuphine (buprenorphine implant).

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Probuphine (buprenorphine implant) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Probuphine?

  • Tell all of your health care providers that you take Probuphine (buprenorphine implant). This includes your doctors, nurses, pharmacists, and dentists.
  • Avoid driving and doing other tasks or actions that call for you to be alert until you see how Probuphine (buprenorphine implant) affects you.
  • To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down. Be careful going up and down stairs.
  • Very bad and sometimes deadly liver problems have happened with Probuphine (buprenorphine implant). Call your doctor right away if you have signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
  • Long-term use of an opioid drug may lead to lower sex hormone levels. Call your doctor if you have a lowered interest in sex, fertility problems, no menstrual period (women), or change in sex ability (men).
  • This medicine may raise the chance of seizures in some people, including people who have had seizures in the past. Talk to your doctor to see if you have a greater chance of seizures while taking Probuphine (buprenorphine implant).
  • Taking an opioid drug like Probuphine (buprenorphine implant) may lead to a rare but very bad adrenal gland problem. Call your doctor right away if you have very bad dizziness or passing out, very bad upset stomach or throwing up, or if you feel less hungry, very tired, or very weak.
  • If you are 65 or older, use Probuphine (buprenorphine implant) with care. You could have more side effects.
  • This medicine may cause harm to the unborn baby if you take it while you are pregnant. If you are pregnant or you get pregnant while taking Probuphine (buprenorphine implant), call your doctor right away.
  • Tell your doctor if you are breast-feeding or plan to breast-feed. This medicine passes into breast milk and may harm your baby.
  • This medicine is not approved for use in children. Talk with the doctor.
  • Follow up with the doctor as you have been told.
  • Be sure you know how to treat pain while you take Probuphine (buprenorphine implant). Do not take opioid pain drugs unless your doctor tells you to. Pain drugs may not work as well while you take Probuphine (buprenorphine implant). Do not take more pain drugs to try to get them to work. If you have an emergency, tell your health care provider that you take Probuphine (buprenorphine implant). If you have questions, talk with your doctor.
  • If you need to stop treatment with Probuphine (buprenorphine implant), you will need to watch for signs of withdrawal. Tell your doctor if you have any bad effects. If you have questions, talk with your doctor.
  • If Probuphine (buprenorphine implant) comes out by itself, keep it away from children. Accidental exposure may cause death. If someone else, especially a child, is exposed to Probuphine (buprenorphine implant) by accident, get medical help right away.
  • Do not try to take Probuphine (buprenorphine implant) out by yourself. This could lead to infection and withdrawal. Talk with your doctor.
  • Try not to touch the area where Probuphine (buprenorphine implant) is put in very often. Touching it often may raise the chance of infection.

How is this medicine (Probuphine) best taken?

Use Probuphine (buprenorphine implant) as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • Do not take Probuphine (buprenorphine implant) with other strong pain drugs or if you are using a pain patch without talking to your doctor first.
  • If you drink grapefruit juice or eat grapefruit often, talk with your doctor.
  • Have blood work checked as you have been told by the doctor. Talk with the doctor.
  • This medicine may cause withdrawal symptoms if you are dependent or addicted to narcotics. Talk with your doctor.
  • It is put in as an implant under the skin.
  • If the implant is sticking out of the skin or comes out by itself, call your doctor right away. Follow what your doctor has told you to do.

What do I do if I miss a dose?

  • Call your doctor to find out what to do.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Trouble breathing, slow breathing, or shallow breathing.
  • Too much sweat.
  • Fast or slow heartbeat.
  • A heartbeat that does not feel normal.
  • Very bad constipation.
  • Feeling very tired or weak.
  • Feeling nervous and excitable.
  • Fever or chills.
  • Sore throat.
  • Change in balance.
  • Mood changes.
  • Very bad belly pain.
  • Extra muscle action or slow movement.
  • Swelling in the arms or legs.
  • Change in eyesight.
  • A burning, numbness, or tingling feeling that is not normal.
  • Trouble speaking.
  • Chest pain or pressure or passing out.
  • Trouble passing urine.
  • Hallucinations (seeing or hearing things that are not there).
  • Muscle or joint pain.
  • Memory problems or loss.
  • Seizures.
  • Very bad headache.
  • Shakiness.
  • Slurred speech, stumbling, or feeling confused, very sleepy or dizzy, or drunk.
  • Not able to focus.
  • A severe and sometimes deadly problem called serotonin syndrome may happen if you take Probuphine (buprenorphine implant) with certain other drugs. Call your doctor right away if you have agitation; change in balance; confusion; hallucinations; fever; fast or abnormal heartbeat; flushing; muscle twitching or stiffness; seizures; shivering or shaking; sweating a lot; severe diarrhea, upset stomach, or throwing up; or severe headache.
  • Low mood (depression).
  • Irritation where Probuphine (buprenorphine implant) is given.
  • Swelling, warmth, or redness where Probuphine (buprenorphine implant) was given.

What are some other side effects of Probuphine?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Constipation.
  • Dizziness.
  • Feeling sleepy.
  • Upset stomach or throwing up.
  • Stomach pain or diarrhea.
  • Feeling tired or weak.
  • Headache.
  • Trouble sleeping.
  • Back pain.
  • Dry mouth.
  • Tooth pain.
  • Mouth pain.
  • Throat pain.
  • Signs of a common cold.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Probuphine?

  • If you need to store Probuphine (buprenorphine implant) at home, talk with your doctor, nurse, or pharmacist about how to store it.

Consumer information use

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
  • This medicine comes with an extra patient fact sheet called a Medication Guide. Read it with care. Read it again each time Probuphine (buprenorphine implant) is refilled. If you have any questions about Probuphine (buprenorphine implant), please talk with the doctor, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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