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Generic name: naloxone hydrochloride
Dosage form: nasal spray
Drug class: Antidotes

Medically reviewed by Judith Stewart, BPharm. Last updated on Sep 1, 2021.

What is Kloxxado nasal spray?

  • Kloxxado nasal spray is a prescription medicine used for the treatment of an opioid emergency such as an overdose or a possible opioid overdose with signs of breathing problems and severe sleepiness or not being able to respond.
  • Kloxxado nasal spray is to be given right away and does not take the place of emergency medical care.
  • Get emergency medical help right away after giving the first dose of Kloxxado nasal spray, even if the person wakes up.
  • Kloxxado nasal spray is safe and effective in children for known or suspected opioid overdose.

You and your family members or caregivers should read this Patient Information leaflet before an opioid emergency happens. This information does not take the place of talking with your healthcare provider about your medical condition or your treatment.

Important information

Kloxxado nasal spray is used to temporarily reverse the effects of opioid medicines. The medicine in the nasal spray has no effect in people who are not taking opioid medicines. Always carry Kloxxado nasal spray with you in case of an opioid emergency.

1. Use Kloxxado nasal spray right away if you or your caregiver think signs or symptoms of an opioid emergency are present, even if you are not sure, because an opioid emergency can cause severe injury or death. Signs and symptoms of an opioid emergency may include:

    • unusual sleepiness and you are not able to awaken the person with a loud voice or by rubbing firmly on the middle of their chest (sternum)
    • breathing problems including slow or shallow breathing in someone difficult to awaken or who looks like they are not breathing
    • the black circle in the center of the colored part of the eye (pupil) is very small, sometimes called “pinpoint pupils,” in someone difficult to awaken

2. Family members, caregivers, or other people who may have to use Kloxxado nasal spray in an opioid emergency should know where the nasal spray is stored and how to give the nasal spray before an opioid emergency happens.
3. Get emergency medical help right away after giving the first dose of nasal spray. Rescue breathing or CPR (cardiopulmonary resuscitation) may be given while waiting for emergency medical help.
4. The signs and symptoms of an opioid emergency can return after Kloxxado nasal spray is given. If this happens, give another dose after 2 to 3 minutes using a new Kloxxado nasal spray and watch the person closely until emergency help is received.

Who should not use Kloxxado nasal spray?

Do not use Kloxxado nasal spray:

  • if you are allergic to naloxone hydrochloride or any of the ingredients in the nasal spray. See the end of this page for a complete list of ingredients.

Before using Kloxxado nasal spray

Before using Kloxxado nasal spray, tell your healthcare provider about all of your medical conditions, including if you:

  • have heart problems
  • are pregnant or plan to become pregnant. Use of Kloxxado nasal spray may cause withdrawal symptoms in your unborn baby. Your unborn baby should be examined by a healthcare provider right away after you use Kloxxado nasal spray.
  • are breastfeeding or plan to breastfeed. It is not known if Kloxxado nasal spray passes into your breast milk.

Tell your healthcare provider about the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

How do I use Kloxxado nasal spray?

Read the “Instructions for Use” at the end of this Patient Information leaflet for detailed information about the right way to use the nasal spray.

  • Use Kloxxado nasal spray exactly as prescribed by your healthcare provider.
  • Each nasal spray contains only 1 dose of medicine and cannot be reused.
  • Lay the person on their back. Support their neck with your hand and allow the head to tilt back before giving the nasal spray.
  • The nasal spray should be given into one nostril.
  • If additional doses are needed, give Kloxxado nasal spray in the other nostril.

Kloxxado side effects

Kloxxado nasal spray may cause serious side effects, including:

  • Sudden opioid withdrawal symptoms. In someone who has been using opioids regularly, opioid withdrawal symptoms can happen suddenly after receiving Kloxxado nasal spray and may include:
    • body aches
    • diarrhea
    • increased heart rate
    • fever
    • runny nose
    • sneezing
    • goose bumps
    • sweating
    • yawning
    • nausea or vomiting
    • nervousness
    • restlessness or irritability
    • shivering or trembling
    • stomach cramping
    • weakness
    • increased blood pressure

In infants under 4 weeks old who have been receiving opioids regularly, sudden opioid withdrawal may be lifethreatening if not treated the right way. Signs and symptoms include: seizures, crying more than usual, and increased reflexes.

The most common side effects in adults include: stomach-area (abdomen) pain, weakness, dizziness, headache, nose (nasal) discomfort and a feeling like you are going to faint.

These are not all of the possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

How should I store Kloxxado nasal spray?

  • Store at room temperature 68ºF to 77ºF (20°C to 25°C).
  • Do not freeze. Do not expose to temperatures below 41°F (5°C) or above 104°F (40°C).
  • Keep the nasal spray in its box until ready to use. Protect from light.
  • Replace the nasal spray before the expiration date on the box.

Keep all medicines out of the reach of children and pets.

General information about the safe and effective use of Kloxxado nasal spray.

Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. Do not use Kloxxado nasal spray for a condition for which it was not prescribed. You can ask your pharmacist or healthcare provider for information that is written for health professionals.

What other drugs will affect Kloxxado?

Other drugs may interact with naloxone, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.

What are the ingredients in Kloxxado nasal spray?

Active ingredient: naloxone hydrochloride
Inactive ingredients: dehydrated alcohol (20% (w/w)) edetate disodium dihydrate, propylene glycol, purified water, and sodium hydroxide and hydrochloric acid to adjust pH.
Kloxxado nasal spray is not made with natural rubber latex.


You and your family members or caregivers should read the Instructions for Use that comes with Kloxxado nasal spray before using it. Talk to your healthcare provider if you and your family members or caregivers have any questions about the use of Kloxxado nasal spray.

Use Kloxxado nasal spray for known or suspected opioid overdose in adults and children.

Important: For use in the nose only.

  • Do not remove or test the Kloxxado nasal spray until ready to use.
  • Each nasal spray has 1 dose and cannot be reused.
  • You do not need to prime the nasal spray.

How to use Kloxxado nasal spray:

Step 1. Lay the person on their back to receive a dose of Kloxxado nasal spray.
Step 2. Remove the nasal spray from the box. Peel back the tab with the black triangle to open the the nasal spray blister.
Note: Kloxxado freezes at temperatures below 5°F (-15°C). If this happens, the device will not spray. Get emergency medical help right away if this happens. Do not wait for it to thaw. Kloxxado may still be used if it has been thawed after being previously frozen.
Step 3. Hold the nasal spray with your thumb on the bottom of the plunger and your first and middle fingers on either side of the nozzle. Do not apply any pressure until you are ready to give the dose.
Step 4. Tilt the person’s head back and provide support under the neck with your hand.
Gently insert the tip of the nozzle into one nostril until your fingers on either side of the nozzle are against the bottom of
Step 5. Press the plunger firmly to give the dose of nasal spray.
Step 6. Remove the nasal spray from the nostril after giving the dose.
What to do after Kloxxado nasal spray has been used:
Step 7. Get emergency help right away.

  • Move the person on their side (recovery position) after giving the nasal spray.
  • Watch the person closely.
  • If the person does not respond by waking up, to voice or touch, or start breathing normally, another dose may be given.
  • Repeat Steps 2 through 6 using a new Kloxxado nasal spray to give another dose in the other nostril.

If additional Kloxxado nasal sprays are available, Steps 2 through 6 may be repeated every 2 to 3 minutes until the person responds or emergency medical help is received.
Step 8. Put the used nasal spray back into its box.
Step 9. Throw away (dispose of) the used nasal spray in a place that is away from children.

Popular FAQ

Is naloxone an opioid antagonist?

Naloxone is a centrally acting opioid receptor antagonist. Naloxone binds with the highest affinity to the mu-opioid receptor subtype in the central nervous system (CNS). Naloxone works to reverse opioid overdose.

Is naloxone a controlled substance?

Naloxone is not a controlled substance, according to the US Drug Enforcement Administration (DEA). It is an opioid antagonist used to treat known or suspected opioid overdose.

Naloxone blocks opioid receptors from 30 to 120 minutes, but this can be variable and depends upon the dose and how it is given. Some patients may need repeat doses of naloxone. Continue reading

Naloxone works in an overdose by reversing serious or deadly central nervous system (CNS) depression due to opioids (narcotics), including depressed breathing, extreme drowsiness and loss of consciousness. This effect usually occurs in minutes. Naloxone is considered a pure opioid antagonist and it works by blocking opioid receptors in the body. Continue reading

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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.