Drugs containing Naloxone: Suboxone, Zubsolv, Narcan Nasal Spray, Evzio, Kloxxado, Zimhi, Talwin Nx, Narcan Injection, Targiniq ER, Cassipa, Show all 11 »Bunavail
Naloxone Levels and Effects while Breastfeeding
Summary of Use during Lactation
No information is available on the excretion of naloxone into breastmilk. Because it is not orally bioavailable, it is unlikely to affect the breastfed infant. However, if naloxone is required by the mother for an opiate overdose, she should withhold nursing until the opiate is out of her system.
Drug Levels
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
In contrast to its effect in some animal species, naloxone does not affect suckling-induced secretion of oxytocin or prolactin in postpartum women.[1,2]
Cholst IN, Wardlaw SL, Newman CB, et al. Prolactin response to breast stimulation in lactating women is not mediated by endogenous opioids. Am J Obstet Gynecol. 1984;150:558–61. [PubMed: 6496587]
2.
Johnson MR, Andrews MA, Seckl JR, et al. Effect of naloxone on neurohypophyseal peptide responses to breast feeding and breast stimulation in man. Clin Endocrinol (Oxf). 1990;33:81–6. [PubMed: 2401100]
Substance Identification
Substance Name
Naloxone
CAS Registry Number
465-65-6
Drug Class
Breast Feeding
Lactation
Narcotic Antagonists
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
