Naloxone Alternatives Compared
| Naloxone | Narcan Nasal Spray | Kloxxado |
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| Naloxone | Narcan Nasal Spray naloxone | Kloxxado naloxone |
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Prescribed for Reversal of Opioid Sedation, Opioid Overdose. naloxone may also be used for purposes not listed in this medication guide. |
Prescribed for Reversal of Opioid Sedation, Opioid Overdose. Narcan Nasal Spray may also be used for purposes not listed in this medication guide. |
Prescribed for Reversal of Opioid Sedation, Opioid Overdose. Kloxxado may also be used for purposes not listed in this medication guide. |
Choose a suggestion below Opioid Overdose
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| More about Naloxone | More about Narcan Nasal Spray (naloxone) | More about Kloxxado (naloxone) | ||||||||||||||||||||||||
| Generic Status | ||||||||||||||||||||||||||
| Availability | ||||||||||||||||||||||||||
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Prescription only |
Prescription only |
Prescription only |
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| Ratings & Reviews | ||||||||||||||||||||||||||
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Naloxone has an average rating of 8.1 out of 10 from a total of 22 ratings on Drugs.com. 77% of reviewers reported a positive effect, while 18% reported a negative effect. |
Narcan Nasal Spray has an average rating of 10.0 out of 10 from a total of 3 ratings on Drugs.com. 100% of reviewers reported a positive effect, while 0% reported a negative effect. |
Be the first to share your experience with this drug. |
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| Drug Class | ||||||||||||||||||||||||||
| Side Effects | ||||||||||||||||||||||||||
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See the full naloxone side effects document. |
See the full Narcan Nasal Spray side effects document. |
See the full Kloxxado side effects document. |
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| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||||||||||
View all naloxone prices |
View all Narcan Nasal Spray prices and generic prices |
View all Kloxxado prices and generic prices |
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| Dosage Form(s) Available | ||||||||||||||||||||||||||
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| Brand Names | ||||||||||||||||||||||||||
| Kloxxado, Narcan Nasal Spray, Zimhi | Other naloxone brands include: Kloxxado, Zimhi | Other naloxone brands include: Narcan Nasal Spray, Zimhi | ||||||||||||||||||||||||
| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | ||||||||||||||||||||||||||
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3 hours |
3 hours |
3 hours |
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| CSA Schedule** View glossary of terms | ||||||||||||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||||||||||||||||||
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Category C
Risk cannot be ruled out
See the full Pregnancy Warnings document. |
Category C
Risk cannot be ruled out
See the full Pregnancy Warnings document. |
Category C
Risk cannot be ruled out
See the full Pregnancy Warnings document. |
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| Drug Interactions | ||||||||||||||||||||||||||
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A total of 30 drugs are known to interact with naloxone:
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A total of 30 drugs are known to interact with Narcan Nasal Spray:
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A total of 30 drugs are known to interact with Kloxxado:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | ||||||||||||||||||||||||||
| First Approval Date | ||||||||||||||||||||||||||
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April 13, 1971 |
N/A |
April 29, 2021 |
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| WADA Class View World Anti-Doping Agency classifications. | ||||||||||||||||||||||||||
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N/A |
N/A |
N/A |
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| More Information | ||||||||||||||||||||||||||
| Patient resources | ||||||||||||||||||||||||||
| Professional Resources | ||||||||||||||||||||||||||
| Related Treatment Guide | ||||||||||||||||||||||||||
** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.