Naloxone Alternatives Compared
| Naloxone | Narcan (naloxone) | Kloxxado (naloxone) |
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| Naloxone | Narcan (naloxone) | Kloxxado (naloxone) |
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Prescription and OTC
Naloxone can be used by consumers and the lay-public, first-responders and healthcare providers to help reverse an overdose due to opioids (narcotics) like heroin and prescription opioids. It can be... View more |
Over-the-counter
Prescribed for Opioid Overdose. Narcan may also be used for purposes not listed in this medication guide. |
Prescription only
Prescribed for Reversal of Opioid Sedation, Opioid Overdose. Kloxxado may also be used for purposes not listed in this medication guide. |
Related suggestions |
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| More about Naloxone | More about Narcan (naloxone) | More about Kloxxado (naloxone) | ||||||||||||||||||||||||
| Ratings & Reviews | ||||||||||||||||||||||||||
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Naloxone has an average rating of 7.7 out of 10 from a total of 27 ratings on Drugs.com. 70% of reviewers reported a positive effect, while 22% reported a negative effect. |
Narcan has an average rating of 8.2 out of 10 from a total of 5 ratings on Drugs.com. 80% of reviewers reported a positive effect, while 20% reported a negative effect. |
Kloxxado has an average rating of 10.0 out of 10 from a total of 1 ratings on Drugs.com. 100% of reviewers reported a positive effect, while 0% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | ||||||||||||||||||||||||||
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View all Naloxone side effects |
View all Narcan side effects |
View all Kloxxado side effects |
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| Drug Class | ||||||||||||||||||||||||||
| Generic Availability | ||||||||||||||||||||||||||
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Lower cost generic |
Lower cost generic approved | |||||||||||||||||||||||||
| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||||||||||
View all Naloxone prices |
View all Narcan prices |
View all Kloxxado prices |
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| Dosage Forms | ||||||||||||||||||||||||||
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| Brand Names | ||||||||||||||||||||||||||
| Kloxxado, Narcan, Rextovy, Rezenopy, RiVive, Zimhi | Other naloxone brands include: Kloxxado, Rextovy, Rezenopy, RiVive, Zimhi | Other naloxone brands include: Narcan, Rextovy, Rezenopy, RiVive, Zimhi | ||||||||||||||||||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | ||||||||||||||||||||||||||
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3 hours |
3 hours |
3 hours |
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| CSA Schedule 1 View glossary of CSA terms | ||||||||||||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||||||||||||||||||
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | ||||||||||||||||||||||||||
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A total of 30 drugs are known to interact with Naloxone:
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A total of 30 drugs are known to interact with Narcan:
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A total of 30 drugs are known to interact with Kloxxado:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | ||||||||||||||||||||||||||
| First Approval Date | ||||||||||||||||||||||||||
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April 13, 1971 |
N/A |
April 29, 2021 |
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| WADA Class View classifications | ||||||||||||||||||||||||||
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N/A |
N/A |
N/A |
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| Related Treatment Guide | ||||||||||||||||||||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
See also:
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.