Naloxone Alternatives Compared
| Naloxone | Narcan (naloxone) | Kloxxado (naloxone) |
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| Naloxone | Narcan (naloxone) | Kloxxado (naloxone) |
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Prescription and OTC
Naloxone can be used by consumers and the lay-public, first-responders and healthcare providers to help reverse an overdose due to opioids (narcotics) like heroin and prescription opioids. It can be... View more |
Over-the-counter
Prescribed for Opioid Overdose. Narcan may also be used for purposes not listed in this medication guide. |
Prescription only
Prescribed for Reversal of Opioid Sedation, Opioid Overdose. Kloxxado may also be used for purposes not listed in this medication guide. |
Related suggestions |
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| More about Naloxone | More about Narcan (naloxone) | More about Kloxxado (naloxone) | ||||||||||||||||||||||||
| Ratings & Reviews | ||||||||||||||||||||||||||
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Naloxone has an average rating of 7.7 out of 10 from a total of 27 ratings on Drugs.com. 70% of reviewers reported a positive effect, while 22% reported a negative effect. |
Narcan has an average rating of 8.2 out of 10 from a total of 5 ratings on Drugs.com. 80% of reviewers reported a positive effect, while 20% reported a negative effect. |
Kloxxado has an average rating of 10.0 out of 10 from a total of 1 ratings on Drugs.com. 100% of reviewers reported a positive effect, while 0% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | ||||||||||||||||||||||||||
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View all Naloxone side effects |
View all Narcan side effects |
View all Kloxxado side effects |
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| Drug Class | ||||||||||||||||||||||||||
| Generic Availability | ||||||||||||||||||||||||||
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Lower cost generic |
Lower cost generic approved | |||||||||||||||||||||||||
| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||||||||||
View all Naloxone prices |
View all Narcan prices |
View all Kloxxado prices |
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| Dosage Forms | ||||||||||||||||||||||||||
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| Brand Names | ||||||||||||||||||||||||||
| Kloxxado, Narcan, Rextovy, Rezenopy, RiVive, Zimhi | Other naloxone brands include: Kloxxado, Rextovy, Rezenopy, RiVive, Zimhi | Other naloxone brands include: Narcan, Rextovy, Rezenopy, RiVive, Zimhi | ||||||||||||||||||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | ||||||||||||||||||||||||||
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3 hours |
3 hours |
3 hours |
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| CSA Schedule 1 View glossary of CSA terms | ||||||||||||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||||||||||||||||||
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | ||||||||||||||||||||||||||
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A total of 30 drugs are known to interact with Naloxone:
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A total of 30 drugs are known to interact with Narcan:
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A total of 30 drugs are known to interact with Kloxxado:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | ||||||||||||||||||||||||||
| First Approval Date | ||||||||||||||||||||||||||
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April 13, 1971 |
N/A |
April 29, 2021 |
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| WADA Class View classifications | ||||||||||||||||||||||||||
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N/A |
N/A |
N/A |
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| Related Treatment Guide | ||||||||||||||||||||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
See also:
Narcan
Narcan (naloxone) nasal spray is used to treat opioid overdose. Includes dosage, instructions ...
Opvee
Opvee Nasal Spray is used to treat opioid overdose in patients 12 years and older. Opvee ...
Botox
Botox is used for cosmetic purposes and to treat overactive bladder symptoms, urinary incontinence ...
Kloxxado
Kloxxado (naloxone hydrochloride) is used for the emergency treatment of opioid overdose. Includes ...
Zimhi
Zimhi is used for the treatment of an opioid emergency such as an overdose or a possible opioid ...
Zurnai
Zurnai (nalmefene) is an opioid antagonist autoinjector that may be used for the emergency ...
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.