Omeprazole and Sodium Bicarbonate Capsules
Generic name: Omeprazole and Sodium Bicarbonate Capsules [ oh-MEP-ra-zole-& SOW-dee-um-bye-KAR-bun-ate ]
Brand names: Zegerid, Zegerid OTC
Drug class: Proton pump inhibitors
Medically reviewed by Drugs.com. Last updated on Jan 24, 2023.
Uses of Omeprazole and Sodium Bicarbonate Capsules:
- It is used to treat gastroesophageal reflux disease (GERD; acid reflux).
- It is used to treat heartburn.
- It is used to treat GI (gastrointestinal) ulcers.
- It is used to treat or prevent ulcers of the swallowing tube (esophagus).
- It may be given to you for other reasons. Talk with the doctor.
What do I need to tell my doctor BEFORE I take Omeprazole and Sodium Bicarbonate Capsules?
- If you are allergic to this medicine (omeprazole and sodium bicarbonate capsules); any part of this medicine (omeprazole and sodium bicarbonate capsules); or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
- If you have any of these health problems: Bartter's syndrome, low calcium or potassium levels, or acid-base problems in the blood.
- If you are taking any of these drugs: Atazanavir, clopidogrel, nelfinavir, rifampin, rilpivirine, or St. John's wort.
This is not a list of all drugs or health problems that interact with this medicine (omeprazole and sodium bicarbonate capsules).
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this medicine (omeprazole and sodium bicarbonate capsules) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
What are some things I need to know or do while I take Omeprazole and Sodium Bicarbonate Capsules?
- Tell all of your health care providers that you take this medicine (omeprazole and sodium bicarbonate capsules). This includes your doctors, nurses, pharmacists, and dentists.
- If you have high blood sugar (diabetes), you will need to watch your blood sugar closely.
- Call your doctor if you have throat pain, chest pain, very bad belly pain, trouble swallowing, or signs of a bleeding ulcer like black, tarry, or bloody stools, throwing up blood, or throw up that looks like coffee grounds. These may be signs of a worse health problem.
- Do not take this medicine (omeprazole and sodium bicarbonate capsules) for longer than you were told by your doctor.
- This medicine may raise the chance of hip, spine, and wrist fractures in people with weak bones (osteoporosis). The chance may be higher if you take this medicine (omeprazole and sodium bicarbonate capsules) in high doses or for longer than a year, or if you are older than 50 years old.
- Use care if you have risks for soft, brittle bones (osteoporosis). Some of these risks include drinking alcohol, smoking, taking steroids, taking drugs to treat seizures, or having family members with osteoporosis. Talk with your doctor about your risks of osteoporosis.
- Rarely, low magnesium levels have happened in people taking drugs like this one for at least 3 months. Most of the time, this happened after 1 year of treatment. You will need to have blood work if you take this medicine (omeprazole and sodium bicarbonate capsules) for a long time or with certain other drugs.
- Lupus has happened with this medicine (omeprazole and sodium bicarbonate capsules), as well as lupus that has gotten worse in people who already have it. Tell your doctor if you have lupus. Call your doctor right away if you have signs of lupus like a rash on the cheeks or other body parts, sunburn easy, muscle or joint pain, chest pain or shortness of breath, or swelling in the arms or legs.
- Very bad pancreas, liver, and white blood cell problems have happened in people who were taking this medicine (omeprazole and sodium bicarbonate capsules). Rarely, these have been fatal. Talk with the doctor if you have questions.
- This medicine may raise the chance of a severe form of diarrhea called C diff-associated diarrhea (CDAD). Call your doctor right away if you have stomach pain or cramps, very loose or watery stools, or bloody stools. Do not try to treat diarrhea without first checking with your doctor.
- A very bad skin reaction (Stevens-Johnson syndrome/toxic epidermal necrolysis) may happen. It can cause very bad health problems that may not go away, and sometimes death. Get medical help right away if you have signs like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in your mouth, throat, nose, or eyes.
- If you are of Asian descent, use this medicine (omeprazole and sodium bicarbonate capsules) with care. You could have more side effects.
- Tell your doctor if you are pregnant, plan on getting pregnant, or are breast-feeding. You will need to talk about the benefits and risks to you and the baby.
How is this medicine (Omeprazole and Sodium Bicarbonate Capsules) best taken?
Use this medicine (omeprazole and sodium bicarbonate capsules) as ordered by your doctor. Read all information given to you. Follow all instructions closely.
- Take 1 hour before a meal.
- Take with water only; do not take with other drinks.
- Swallow whole. Do not chew, break, or crush.
- Do not open the capsules.
- Ask your doctor before you take antacids with this medicine (omeprazole and sodium bicarbonate capsules).
- Keep taking this medicine (omeprazole and sodium bicarbonate capsules) as you have been told by your doctor or other health care provider, even if you feel well.
- It may take a few days to see the full effect.
- Long-term treatment (for instance longer than 3 years) with drugs like this one has rarely caused low vitamin B-12 levels. Talk with the doctor.
- This medicine may affect certain lab tests. Tell all of your health care providers and lab workers that you take this medicine (omeprazole and sodium bicarbonate capsules).
- If you are on a low-sodium or sodium-free diet, talk with your doctor. Some of these products have sodium.
What do I do if I miss a dose?
- Take a missed dose as soon as you think about it.
- If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
- Do not take 2 doses at the same time or extra doses.
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of low magnesium levels like mood changes, muscle pain or weakness, muscle cramps or spasms, seizures, shakiness, not hungry, very bad upset stomach or throwing up, or a heartbeat that does not feel normal.
- Signs of low potassium levels like muscle pain or weakness, muscle cramps, or a heartbeat that does not feel normal.
- Signs of kidney problems like unable to pass urine, change in how much urine is passed, blood in the urine, or a big weight gain.
- Signs of high blood sugar like confusion, feeling sleepy, more thirst, more hungry, passing urine more often, flushing, fast breathing, or breath that smells like fruit.
- Signs of a pancreas problem (pancreatitis) like very bad stomach pain, very bad back pain, or very bad upset stomach or throwing up.
- Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
- Signs of high or low blood pressure like very bad headache or dizziness, passing out, or change in eyesight.
- Feeling confused.
- A burning, numbness, or tingling feeling that is not normal.
- Bone pain.
- Fever, chills, or sore throat; any unexplained bruising or bleeding; or feeling very tired or weak.
- Weight gain.
What are some other side effects of Omeprazole and Sodium Bicarbonate Capsules?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Stomach pain or diarrhea.
- Upset stomach or throwing up.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch.
If OVERDOSE is suspected:
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
How do I store and/or throw out Omeprazole and Sodium Bicarbonate Capsules?
- Store at room temperature protected from light. Store in a dry place. Do not store in a bathroom.
- Keep lid tightly closed.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
Consumer Information Use and Disclaimer
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else's drugs.
- This medicine comes with an extra patient fact sheet called a Medication Guide. Read it with care. Read it again each time this medicine (omeprazole and sodium bicarbonate capsules) is refilled. If you have any questions about this medicine (omeprazole and sodium bicarbonate capsules), please talk with the doctor, pharmacist, or other health care provider.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
More about omeprazole / sodium bicarbonate
- Check interactions
- Compare alternatives
- Pricing & coupons
- Reviews (38)
- Drug images
- Side effects
- Dosage information
- During pregnancy
- Drug class: proton pump inhibitors
- En español
- Drug Information
- Omeprazole and sodium bicarbonate (Advanced Reading)
- Omeprazole and Sodium Bicarbonate Powder Packets
Related treatment guides
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.