Skip to Content
Could you or a loved one be experiencing depression?

Isocarboxazid

Generic Name: Isocarboxazid (eye soe kar BOKS a zid)
Brand Name: Marplan

  • Drugs like this one have raised the chance of suicidal thoughts or actions in children and young adults. The risk may be greater in people who have had these thoughts or actions in the past. All people who take isocarboxazid need to be watched closely. Call the doctor right away if signs like low mood (depression), nervousness, restlessness, grouchiness, panic attacks, or changes in mood or actions are new or worse. Call the doctor right away if any thoughts or actions of suicide occur.
  • This medicine is not approved for use in children. Talk with the doctor.

Uses of Isocarboxazid:

  • It is used to treat low mood (depression). It is most often given after other drugs have failed to help.

What do I need to tell my doctor BEFORE I take Isocarboxazid?

  • If you have an allergy to isocarboxazid or any other part of this medicine.
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you have any of these health problems: Heart disease, high blood pressure, kidney disease, pheochromocytoma, or stroke or other brain problems.
  • If you have ever had headaches or liver problems.
  • If you are taking or will be taking another drug like this one.
  • If you take any drugs (prescription or OTC, natural products, vitamins) that must not be taken with isocarboxazid, like certain drugs that are used for low mood (depression) or other mood problems, ADHD, or high blood pressure. There are many drugs that must not be taken with this drug.

This is not a list of all drugs or health problems that interact with this medicine.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take isocarboxazid with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Isocarboxazid?

  • Tell all of your health care providers that you take this medicine. This includes your doctors, nurses, pharmacists, and dentists. This medicine may need to be stopped before certain types of surgery as your doctor has told you. If isocarboxazid is stopped, your doctor will tell you when to start taking this medicine again after your surgery or procedure.
  • Avoid driving and doing other tasks or actions that call for you to be alert until you see how isocarboxazid affects you.
  • To lower the chance of feeling dizzy or passing out, rise slowly over a few minutes when sitting or lying down. Be careful climbing stairs.
  • High blood pressure has happened with this medicine. Sometimes, this has been deadly. Have your blood pressure checked as you have been told by your doctor.
  • Have blood work checked as you have been told by the doctor. Talk with the doctor.
  • Some foods and drinks like cheese and red wine, when taken with isocarboxazid, may cause very risky effects such as sudden high blood pressure. To avoid these problems, get a list of foods to avoid.
  • If this medicine is stopped, follow diet for at least 2 more weeks.
  • If you have high blood sugar (diabetes), you will need to watch your blood sugar closely.
  • Do not take isocarboxazid with other drugs for low mood (depression), diet pills, stimulants like amphetamines, reserpine, or pain drugs without talking with your doctor. There needs to be some time between stopping one drug and starting the other. Talk with your doctor about all the drugs you take.
  • Do not use OTC drugs that have dextromethorphan or pseudoephedrine. They may cause very high blood pressure when used with this medicine.
  • If you are taking isocarboxazid and have high blood pressure, talk with your doctor before using OTC products that may raise blood pressure. These include cough or cold drugs, diet pills, stimulants, ibuprofen or like products, and some natural products or aids.
  • Avoid alcohol or other drugs and natural products that slow your actions.
  • This medicine may raise the chance of seizures in some people, including people who have had seizures in the past. Talk to your doctor to see if you have a greater chance of seizures while taking this medicine.
  • Limit your use of caffeine (for example, tea, coffee, cola) and chocolate. Use with isocarboxazid may cause nervousness, shakiness, and a fast heartbeat.
  • Do not give to a child younger than 16 years of age.
  • Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using this medicine while you are pregnant.
  • Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.

How is this medicine (Isocarboxazid) best taken?

Use isocarboxazid as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • Take with or without food.
  • To gain the most benefit, do not miss doses.
  • Keep taking this medicine as you have been told by your doctor or other health care provider, even if you feel well.

What do I do if I miss a dose?

  • Take a missed dose as soon as you think about it.
  • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
  • Do not take 2 doses at the same time or extra doses.

See also: Dosage Information (in more detail)

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
  • Weakness on 1 side of the body, trouble speaking or thinking, change in balance, drooping on one side of the face, or blurred eyesight.
  • Chest pain or pressure.
  • Fast or slow heartbeat.
  • Very upset stomach or throwing up.
  • Headache.
  • A heartbeat that does not feel normal.
  • Neck stiffness.
  • Sweating a lot.
  • Larger pupils.
  • If bright lights bother your eyes.
  • Very bad dizziness or passing out.
  • Seizures.

What are some other side effects of Isocarboxazid?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Upset stomach.
  • Dry mouth.
  • Dizziness.
  • Feeling sleepy.
  • Hard stools (constipation).
  • Not able to sleep.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

See also: Side effects (in more detail)

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Isocarboxazid?

  • Store at room temperature.
  • Protect from light.
  • Store in a dry place. Do not store in a bathroom.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Check with your pharmacist about how to throw out unused drugs.

Consumer Information Use and Disclaimer

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • This medicine comes with an extra patient fact sheet called a Medication Guide. Read it with care. Read it again each time isocarboxazid is refilled. If you have any questions about this medicine, please talk with the doctor, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

This information should not be used to decide whether or not to take isocarboxazid or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to isocarboxazid. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine.

Review Date: September 6, 2017

Hide