Generic Name: eplerenone (e-PLER-en-one)
Brand Name: Inspra
Inspra is used for:
Treating high blood pressure alone or along with other medicines. It is also used to improve survival in patients who have certain heart problems (left ventricular systolic dysfunction and congestive heart failure) following a heart attack. It may also be used for other conditions as determined by your doctor.
Inspra is an aldosterone blocker. It works by blocking the hormone aldosterone, which lowers the amount of sodium and water the body retains. This helps to lower blood pressure to help prevent strokes, heart attacks, and kidney problems.
Do NOT use Inspra if:
- you are allergic to any ingredient in Inspra
- you have severe kidney problems or high blood potassium levels
- you are taking Inspra to treat high blood pressure, and you have type 2 diabetes with protein in your urine
- you are taking clarithromycin, itraconazole, ketoconazole, nefazodone, nelfinavir, ritonavir, or troleandomycin
- you are taking Inspra to treat high blood pressure, and you are taking potassium supplements or potassium-sparing diuretics (eg, amiloride, spironolactone, triamterene)
Contact your doctor or health care provider right away if any of these apply to you.
Before using Inspra:
Some medical conditions may interact with Inspra. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have kidney problems, diabetes, or protein in your urine
- if you have a history of high blood potassium levels
Some MEDICINES MAY INTERACT with Inspra. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril), angiotensin-receptor blockers (eg, valsartan), potassium supplements, or potassium-sparing diuretics (eg, amiloride, spironolactone, triamterene) because the risk of high blood potassium levels may be increased
- Azole antifungals (eg, fluconazole, itraconazole, ketoconazole), macrolide antibiotics (eg, clarithromycin, erythromycin, troleandomycin ), nefazodone, protease inhibitors (eg, nelfinavir, ritonavir, saquinavir), or verapamil because they may increase the risk of Inspra's side effects
- Nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen, naproxen) because they may decrease Inspra's effectiveness and increase the risk of high blood potassium levels
- Lithium because the risk of its side effects may be increased by Inspra
How to use Inspra:
Use Inspra as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Take Inspra by mouth with or without food.
- Take Inspra regularly to receive the most benefit from it. Taking Inspra at the same time each day will help you remember to take it.
- If you miss a dose of Inspra, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Inspra.
Important safety information:
- Inspra may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Inspra with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- It may take up to 4 weeks to see the full benefit of Inspra on your blood pressure. Do not stop taking Inspra without checking with your doctor.
- Do not exceed the recommended dose of Inspra. Doing so will not improve your condition faster and may lead to side effects.
- Do not use a salt substitute or a potassium supplement without checking with your doctor.
- Tell your doctor or dentist that you take Inspra before you receive any medical or dental care, emergency care, or surgery.
- Patients who take medicine for high blood pressure often feel tired or rundown for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel quite "normal." Tell your doctor if you develop any new symptoms.
- Lab tests, including blood potassium levels, blood pressure measurements, and kidney function, may be performed while you use Inspra. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
- Use Inspra with caution in the ELDERLY; they may be more sensitive to its effects, especially high blood potassium levels.
- Inspra should be used with extreme caution in CHILDREN younger than 4 years old; safety and effectiveness in these children have not been confirmed.
- PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Inspra while you are pregnant. It is not known if this medicine is found in breast milk. Do not breast-feed while taking Inspra.
Possible side effects of Inspra:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); abnormal vaginal bleeding; chest pain; enlarged or sore breasts in men; fast or irregular heartbeat; severe or persistent diarrhea or dizziness; swelling of the legs, ankles, or feet; vomiting.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include fainting; irregular heartbeat; severe or persistent dizziness or light-headedness.Proper storage of Inspra:
Store Inspra at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Inspra out of the reach of children and away from pets.
- If you have any questions about Inspra, please talk with your doctor, pharmacist, or other health care provider.
- Inspra is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take Inspra or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Inspra. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Inspra. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Inspra.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.
More about Inspra (eplerenone)
- Side Effects
- During Pregnancy
- Dosage Information
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- Drug Interactions
- Support Group
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- En Español
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- Generic Availability
- Drug class: aldosterone receptor antagonists