Generic Name: esomeprazole (ES-oh-MEP-ra-zole)
Brand Name: Nexium I.V.
Esomeprazole is used for:
Short-term treatment of gastroesophageal reflux disease (GERD) in patients with irritation and swelling of the esophagus when medicine cannot be taken by mouth. It is also used to reduce the risk of bleeding ulcers after a certain procedure (endoscopy). It may also be used for other conditions as determined by your doctor.
Esomeprazole is a proton pump inhibitor (PPI). It works by decreasing the amount of acid produced in the stomach.
Do NOT use esomeprazole if:
- you are allergic to any ingredient in esomeprazole or to any similar medicine (eg, omeprazole)
- you are taking atazanavir, clopidogrel, dasatinib, nelfinavir, rifampin, rilpivirine, or St. John's wort
Contact your doctor or health care provider right away if any of these apply to you.
Before using esomeprazole:
Some medical conditions may interact with esomeprazole. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have low blood potassium or magnesium levels, low blood vitamin B12 levels or vitamin B12 deficiency, liver problems, or stomach or bowel cancer
- if you have osteoporosis (weak bones), a family history of osteoporosis, or other risk factors of osteoporosis (eg, smoking, poor nutrition)
Some MEDICINES MAY INTERACT with esomeprazole. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Diuretics (eg, furosemide, hydrochlorothiazide) because the risk of low blood magnesium levels may be increased
- Voriconazole because it may increase the risk of esomeprazole's side effects
- Ginkgo biloba, rifampin, or St. John's wort because they may decrease esomeprazole's effectiveness
- Anticoagulants (eg, warfarin), cilostazol, diazepam, digoxin, methotrexate, saquinavir, or tacrolimus because the risk of their side effects may be increased by esomeprazole
- Atazanavir, bosutinib, clopidogrel, dasatinib, erlotinib, indinavir, iron, itraconazole, ketoconazole, mycophenolate, nelfinavir, nilotinib, posaconazole, rilpivirine, or sorafenib because their effectiveness may be decreased by esomeprazole
This may not be a complete list of all interactions that may occur. Ask your health care provider if esomeprazole may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use esomeprazole:
Use esomeprazole as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Esomeprazole is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using esomeprazole at home, a health care provider will teach you how to use it. Be sure you understand how to use esomeprazole. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
- Do not use esomeprazole if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
- Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
- Esomeprazole should only be used for a short time (up to 10 days), until you are able to take medicine by mouth. Discuss any questions or concerns with your doctor.
- Continue to use esomeprazole even if you feel well. Do not miss any doses.
- If you miss a dose of esomeprazole, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.
Ask your health care provider any questions you may have about how to use esomeprazole.
Important safety information:
- Esomeprazole may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use esomeprazole with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Do NOT change your dose, stop taking esomeprazole, or take esomeprazole for longer than prescribed without checking with your doctor.
- Contact your doctor if you have any symptoms of a bleeding ulcer, such as black, tarry stools or vomit that looks like coffee grounds, or if you experience throat pain, chest pain, severe stomach pain, or trouble swallowing.
- Esomeprazole may increase the risk of a serious form of diarrhea. Contact your doctor right away if stomach pain or cramps, severe or persistent diarrhea, or bloody or watery stools occur. Discuss any questions or concerns with your doctor.
- Esomeprazole may increase the risk of hip, wrist, and spine fractures in patients with weak bones (osteoporosis). The risk may be greater if you use esomeprazole in high doses, for long periods of time, or if you are older than 50 years old. Contact your doctor if you have any questions about this information.
- Low blood magnesium levels have been reported rarely in patients taking PPIs for at least 3 months. In most cases, this effect was seen after a year of treatment. If you will be taking esomeprazole for a long time, or if you take certain other medicines (eg, digoxin, diuretics), your doctor may perform lab tests to check for low blood magnesium levels. Seek medical attention right away if you experience symptoms of low blood magnesium levels (eg, dizziness; fast or irregular heartbeat; involuntary muscle movements; jitteriness or tremors; muscle aches, cramps, pain, spasms, or weakness; seizures).
- Long-term treatment (eg, longer than 3 years) with medicines like this one has rarely caused low vitamin B12 levels. Discuss any questions or concerns with your doctor.
- Check with your doctor to see whether you should take a calcium and vitamin D supplement while you use esomeprazole.
- Esomeprazole may interfere with certain lab tests. Be sure your doctor and lab personnel know you are using esomeprazole.
- Use esomeprazole with caution in the ELDERLY; they may be more sensitive to its effects, especially hip, wrist, and spine fractures.
- PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using esomeprazole while you are pregnant. It is not known if this medicine is found in breast milk. Do not breast-feed while using esomeprazole.
Possible side effects of esomeprazole:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Constipation; drowsiness; dry mouth; gas; headache; mild diarrhea or stomach pain; nausea.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest or throat; swelling of the mouth, face, lips, or tongue; unusual hoarseness); bloody or watery stools; bone pain; chest pain; confusion; dark urine; difficult or painful urination; fast heartbeat; fever, chills, or persistent sore throat; mental or mood changes (eg, depression); pain, swelling, or redness at the injection site; red, swollen, blistered, or peeling skin; severe or persistent diarrhea or stomach pain; severe or persistent nausea or vomiting; shortness of breath; sluggishness; sore joints; stomach cramps; swelling of the hands, ankles, or feet; symptoms of kidney problems (eg, not able to pass urine, change in the amount of urine produced, blood in the urine, a big weight gain); unexplained weight loss; unusual bruising or bleeding; unusual tiredness or weakness; vision changes; yellowing of the eyes or skin.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.Proper storage of esomeprazole:
Esomeprazole is usually handled and stored by a health care provider. If you are using esomeprazole at home, store esomeprazole as directed by your pharmacist or health care provider. Keep esomeprazole out of the reach of children and away from pets.
- If you have any questions about esomeprazole, please talk with your doctor, pharmacist, or other health care provider.
- Esomeprazole is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take esomeprazole or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about esomeprazole. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to esomeprazole. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your health care provider for complete information about the risks and benefits of using esomeprazole.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.
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