Generic Name: amlodipine/atorvastatin (am-LOE-di-peen/a-TOR-va-STAT-in)
Brand Name: Caduet
Caduet is used for:
Treating patients who have high cholesterol and certain other conditions (eg, high blood pressure, heart blood vessel problems, angina [chest pain]). It may also be used for other conditions as determined by your doctor.
Caduet is a calcium channel blocker (amlodipine) and HMG-CoA reductase inhibitor (atorvastatin) combination. Amlodipine works by widening blood vessels to reduce chest pain and high blood pressure. Atorvastatin works to decrease your risk of heart attack, stroke, and chest pain by lowering "bad" cholesterol (eg, triglycerides) and raising "good" cholesterol (eg, high-density lipoprotein [HDL]) in the blood.
Do NOT use Caduet if:
- you are allergic to any ingredient in Caduet
- you have liver problems or unexplained abnormal liver function tests
- you are pregnant, may become pregnant, or are breast-feeding
- you are taking cimetidine, cyclosporine, gemfibrozil, ketoconazole, mibefradil, spironolactone, telaprevir, or tipranavir plus ritonavir
- you take conivaptan or have taken it in within the past 7 days
Contact your doctor or health care provider right away if any of these apply to you.
Before using Caduet:
Some medical conditions may interact with Caduet. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are able to become pregnant
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have low blood pressure; a severe infection; a blood infection; endocrine, metabolic, or electrolyte problems; or trouble swallowing, or if you are very ill
- if you have a history of heart problems (eg, heart failure, coronary artery disease), blood vessel problems, liver problems, diabetes, thyroid problems, kidney problems, muscle problems (eg, pain, weakness), a stroke, or seizures
- if you are scheduled for major surgery, or have recently had major surgery or a serious injury
- if you drink alcohol or have a history of alcohol abuse
Some MEDICINES MAY INTERACT with Caduet. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Amiodarone, azole antifungals (eg, fluconazole, itraconazole, voriconazole), cobicistat, colchicine, conivaptan, cyclosporine, daptomycin, delavirdine, diltiazem, fibrates (eg, fenofibrate, gemfibrozil), fusidic acid, hepatitis C virus (HCV) protease inhibitors (eg, boceprevir, telaprevir), HIV protease inhibitors (eg, nelfinavir, ritonavir), other HMG-CoA reductase inhibitors (statins) (eg, simvastatin), imatinib, macrolide antibiotics (eg, clarithromycin, erythromycin), mibefradil, mifepristone, nefazodone, niacin, quinine, streptogramins (eg, dalfopristin), telithromycin, or verapamil because the risk of side effects, such as severe muscle or kidney problems, may be increased
- Sildenafil because the risk of low blood pressure may be increased
- Bosentan, carbamazepine, efavirenz, rifamycins (eg, rifampin), or St. John's wort because they may decrease Caduet's effectiveness
- Cimetidine, digoxin, certain hormonal contraceptives (eg, birth control pills), ketoconazole, sirolimus, spironolactone, or tacrolimus because the risk of their side effects may be increased by Caduet
This may not be a complete list of all interactions that may occur. Ask your health care provider if Caduet may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Caduet:
Use Caduet as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- An extra patient leaflet is available with Caduet. Talk to your pharmacist if you have questions about this information.
- Take Caduet by mouth with or without food.
- Swallow Caduet whole. Do not break, crush, or chew before swallowing. If you have a problem swallowing tablets, talk with your doctor.
- Take Caduet on a regular schedule to get the most benefit from it.
- Taking Caduet at the same time each day will help you remember to take it.
- Eating grapefruit or drinking grapefruit juice may increase the amount of Caduet in your blood, which may increase your risk of serious side effects. The risk may be greater with large amounts of grapefruit or grapefruit juice. Avoid large amounts of grapefruit juice (more than 1 quart daily). Talk with your doctor or pharmacist if you have questions about including grapefruit or grapefruit juice in your diet while you are taking Caduet.
- Continue to use Caduet even if you feel well. Most people with high blood pressure or high cholesterol do not have symptoms. Do not miss any doses.
- If you miss a dose of Caduet, take it as soon as possible. If it is more than 12 hours since the missed dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Caduet.
Important safety information:
- Caduet may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Caduet with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Caduet may cause dizziness, light-headedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
- Caduet may cause liver problems. Rarely, severe and sometimes fatal liver problems have been reported in patients taking statin medicines, including Caduet. Your risk of developing liver problems may be greater if you drink alcohol daily or in large amounts, or if you have a history of liver problems. Check with your doctor before drinking alcohol while you are taking Caduet. Tell your doctor right away if you experience symptoms of liver problems (eg, dark urine; pale stools; severe or persistent nausea, loss of appetite, or stomach pain; unusual tiredness; yellowing of the skin or eyes).
- Do NOT take more than the recommended dose without checking with your doctor. Doing so may cause an increase in the risk of severe side effects.
- Follow the diet, exercise, and weight reduction program given to you by your health care provider.
- Proper dental care is important while you are taking Caduet. Brush and floss your teeth and visit the dentist regularly.
- Tell your doctor or dentist that you take Caduet before you receive any medical or dental care, emergency care, or surgery.
- It may take several weeks to receive the full benefits of Caduet. Do not stop using Caduet without checking with your doctor.
- Check with your doctor before using any cough-and-cold products or diet aids because they may contain ingredients that could increase your heart rate or blood pressure.
- If you are taking Caduet for chest pain, it will not relieve the pain of a sudden attack if taken at the time of the attack. It prevents or reduces the number of chest pain attacks only if you take it on a regular schedule.
- Although rare, Caduet has been known to increase chest pain and increase the risk of heart attack, mainly in patients with severe heart disease.
- Have your blood pressure checked regularly while taking Caduet.
- Caduet may infrequently cause muscle damage. The risk may be greater when you first begin to take Caduet, whenever your dose is increased, or if you have a history of kidney problems. The risk is also greater when taken with certain other medicines. Untreated, this can lead to a very serious condition known as rhabdomyolysis and kidney damage. Contact your doctor immediately if you develop muscle pain, tenderness, or weakness, especially if they occur with fever or unusual tiredness. Tell your doctor if you have muscle problems that persist even after your doctor has told you to stop taking Caduet.
- It is recommended that women of childbearing age use effective birth control while taking Caduet because it may cause fetal harm. If you have questions about effective birth control, talk with your doctor.
- Diabetes patients - Caduet may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
- Lab tests, including liver function, blood pressure, and blood cholesterol, may be performed while you use Caduet. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
- Use Caduet with caution in the ELDERLY; they may be more sensitive to its effects, especially muscle problems.
- PREGNANCY and BREAST-FEEDING: Do not use Caduet if you are pregnant. It may cause harm to the fetus. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. One of these medicines is found in breast milk. Do not breast-feed while taking Caduet.
Possible side effects of Caduet:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Diarrhea; dizziness; drowsiness; flushing; headache; mild joint pain; mild stomach pain; nausea; stomach upset; tiredness.
Severe allergic reactions (rash; hives; itching; difficulty breathing or swallowing; tightness in the chest; swelling of the mouth, face, lips, throat, or tongue; unusual hoarseness); burning, numbness, or tingling; change in the amount of urine produced or increased urination; changes in vision; chest, jaw, or arm pain; confusion; fainting; fast, slow, or irregular heartbeat; memory problems; mental or mood problems (eg, depression); muscle aches, pain, tenderness, or weakness, especially with fever, unusual tiredness, or general body discomfort; one-sided weakness; persistent pain, soreness, redness, or swelling of a tendon or joint; red, swollen, blistered, or peeling skin; severe or persistent dizziness or light-headedness; severe stomach or back pain (with or without nausea or vomiting); shortness of breath; slurred speech; stiff muscles, tremors, or muscle movements that are not normal; sudden, severe nausea or vomiting; swelling of the hands, arms, feet, or legs; symptoms of liver problems (eg, dark urine; pale stools; severe or persistent nausea, loss of appetite, or stomach pain; unusual tiredness; yellowing of the skin or eyes); tender, bleeding, or swollen gums; tremor; unexplained weight gain; unusual sweating; weakness; worsening angina pain (eg, longer, more often, more severe).
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.Proper storage of Caduet:
Store Caduet at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Caduet out of the reach of children and away from pets.
- If you have any questions about Caduet, please talk with your doctor, pharmacist, or other health care provider.
- Caduet is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take Caduet or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Caduet. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Caduet. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your health care provider for complete information about the risks and benefits of using Caduet.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.
More about Caduet (amlodipine / atorvastatin)
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- Drug class: antihyperlipidemic combinations