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Caduet Side Effects

Generic name: amlodipine / atorvastatin

Medically reviewed by Last updated on Apr 9, 2023.

Note: This document contains side effect information about amlodipine / atorvastatin. Some dosage forms listed on this page may not apply to the brand name Caduet.

Applies to amlodipine / atorvastatin: oral tablet.

Serious side effects of Caduet

Along with its needed effects, amlodipine/atorvastatin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking amlodipine / atorvastatin:

More common


Incidence not known

Get emergency help immediately if any of the following symptoms of overdose occur while taking amlodipine / atorvastatin:

Symptoms of overdose

Other side effects of Caduet

Some side effects of amlodipine / atorvastatin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common


For Healthcare Professionals

Applies to amlodipine / atorvastatin: oral tablet.


The most common side effect of amlodipine was edema. The most common side effects of atorvastatin were diarrhea, nasopharyngitis, and arthralgia.[Ref]


Common (1% to 10%): Abdominal pain, constipation, diarrhea, dyspepsia, nausea

Uncommon (0.1% to 1%): Flatulence


Common (1% to 10%): Nausea, abdominal pain, constipation, dyspepsia

Uncommon (0.1% to 1%): Dysphagia, diarrhea, flatulence, pancreatitis, vomiting, gingival hyperplasia, dry mouth, flatulence, altered bowel habits

Frequency not reported: Gastritis, loose stools


Very common (10% or more): Diarrhea (up to 14.1%)

Common (1% to 10%): Dyspepsia, nausea, abdominal pain, constipation, flatulence

Uncommon (0.1% to 1%): Abdominal discomfort, vomiting

Rare (less than 0.1%): Eructation[Ref]


Common (1% to 10%): Respiratory tract infection

Uncommon (0.1% to 1%): Pharyngitis, rhinitis


Common (1% to 10%): Epistaxis, respiratory tract infection

Uncommon (0.1% to 1%): Dyspnea, pharyngitis, rhinitis

Frequency not reported: Coughing


Very common (10% or more): Nasopharyngitis (up to 12.9%)

Common (1% to 10%): Pharyngolaryngeal pain, respiratory tract infection, rhinitis

Uncommon (0.1% to 1%): Pharyngitis, asthma

Rare (less than 0.1%): Sinusitis

Frequency not reported: Epistaxis, interstitial lung disease[Ref]


Common (1% to 10%): Back pain, arthralgia, myalgia

Uncommon (0.1% to 1%): Leg cramps


Common (1% to 10%): Back pain, myalgia, arthralgia

Uncommon (0.1% to 1%): Arthrosis, muscle cramps, leg cramps

Frequency not reported: Muscle weakness, twitching


Very common (10% or more): Arthralgia (up to 11.7%)

Common (1% to 10%): Pain in extremity, musculoskeletal pain, muscle spasms, myalgia, back pain

Uncommon (0.1% to 1%): Creatine kinase elevations 10 times the upper limit of normal or greater, leg cramps, neck pain

Rare (less than 0.1%): Myositis, myopathy, muscle fatigue

Frequency not reported: Joint swelling, blood creatine phosphokinase increased

Postmarketing reports: Rhabdomyolysis, tendon rupture, immune-mediated necrotizing myopathy[Ref]


Common (1% to 10%): Accidental injury, asthenia, pain

Uncommon (0.1% to 1%): Vertigo


Very common (10% or more): Edema (up to 10.8%)

Common (1% to 10%): Fatigue, accidental injury, asthenia, pain

Uncommon (0.1% to 1%): Vertigo, malaise, rigors, tinnitus, gynecomastia


Common (1% to 10%): Accidental injury, asthenia

Uncommon (0.1% to 1%): Pain, vertigo, deafness, malaise

Rare (less than 0.1%): Tinnitus, pyrexia

Postmarketing reports: Fatigue, gynecomastia[Ref]


Common (1% to 10%): Palpitation, vasodilation, peripheral edema

Uncommon (0.1% to 1%): Hypertension


Common (1% to 10%): Flushing, palpitation, peripheral edema

Uncommon (0.1% to 1%): Arrhythmia, bradycardia, chest pain, peripheral ischemia, tachycardia, vasculitis, hot flushes, vasodilation, hypotension, postural hypotension

Frequency not reported: Cardiac failure, pulse irregularity, extrasystoles, myocardial infarction


Common (1% to 10%): Hypertension, palpitation

Uncommon (0.1% to 1%): Vasodilation

Postmarketing reports: Chest pain, peripheral edema[Ref]


Common (1% to 10%): GGT increased, ALT increased, AST increased


Uncommon (0.1% to 1%): GGT increased, ALT increased, AST increased, pancreatitis

Postmarketing reports: Jaundice, hepatic enzyme elevations, hepatitis


Common (1% to 10%): Transaminase elevations 3 times the upper limit of normal or greater twice within 4 to 10 days

Uncommon (0.1% to 1%): GGT increased, ALT increased, AST increased

Rare (less than 0.1%): Pancreatitis, hepatitis, cholestasis

Frequency not reported: Transaminases increased, liver function test abnormal, blood alkaline phosphatase increased

Postmarketing reports: Fatal and non-fatal hepatic failure[Ref]

Nervous system

Common (1% to 10%): Headache, dizziness

Uncommon (0.1% to 1%): Paresthesia


Common (1% to 10%): Dizziness, somnolence, headache

Uncommon (0.1% to 1%): Syncope, hypoesthesia, neuropathy peripheral, paresthesia, tremor, postural dizziness

Frequency not reported: Ataxia, hypertonia, migraine, amnesia, parosmia, taste perversion

Postmarketing reports: Extrapyramidal disorder


Common (1% to 10%): Hemorrhagic stroke, headache, dizziness

Uncommon (0.1% to 1%): Hypoesthesia, paresthesia

Rare (less than 0.1%): Peripheral neuropathy

Postmarketing reports: Cognitive impairment, amnesia, dysgeusia[Ref]


Common (1% to 10%): Flu syndrome

Uncommon (0.1% to 1%): Allergic reaction


Common (1% to 10%): Allergic reaction

Uncommon (0.1% to 1%): Flu syndrome


Common (1% to 10%): Flu syndrome

Uncommon (0.1% to 1%): Allergic reaction, infection, influenza

Rare (less than 0.1%): Hypersensitivity, anaphylaxis[Ref]


Common (1% to 10%): Rash


Common (1% to 10%): Rash, rash erythematous

Uncommon (0.1% to 1%): Angioedema, erythema multiforme, pruritus, rash maculopapular, sweating increased, purpura, alopecia

Frequency not reported: Skin discoloration, urticaria, skin dryness, dermatitis, cold and clammy skin


Uncommon (0.1% to 1%): Rash, pruritus, urticaria

Rare (less than 0.1%): Angioedema, alopecia

Postmarketing reports: Angioneurotic edema, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis[Ref]


Uncommon (0.1% to 1%): Depression, insomnia


Uncommon (0.1% to 1%): Insomnia, nervousness, depression, abnormal dreams, anxiety, depersonalization, mood changes

Frequency not reported: Apathy, agitation


Common (1% to 10%): Insomnia

Uncommon (0.1% to 1%): Depression, nightmare[Ref]


Uncommon (0.1% to 1%): Urinary frequency


Common (1% to 10%): Male sexual dysfunction, urinary frequency

Uncommon (0.1% to 1%): Female sexual dysfunction, micturition frequency, micturition disorder, nocturia

Frequency not reported: Dysuria, polyuria


Common (1% to 10%): Urinary tract infection

Uncommon (0.1% to 1%): Urinary frequency, erectile dysfunction

Rare (less than 0.1%): White blood cells urine positive[Ref]



Uncommon (0.1% to 1%): Anorexia, weight gain, weight decrease, hyperglycemia, thirst

Frequency not reported: Increased appetite


Common (1% to 10%): Diabetes

Uncommon (0.1% to 1%): Anorexia

Rare (less than 0.1%): Hypoglycemia

Frequency not reported: Hyperglycemia

Postmarketing reports: Weight increased[Ref]



Uncommon (0.1% to 1%): Abnormal vision, conjunctivitis, diplopia, eye pain

Frequency not reported: Abnormal visual accommodation, xerophthalmia


Uncommon (0.1% to 1%): Vision blurred[Ref]



Uncommon (0.1% to 1%): Leukopenia, thrombocytopenia


Postmarketing reports: Thrombocytopenia[Ref]


1. Product Information. Caduet (amlodipine-atorvastatin). Pfizer U.S. Pharmaceuticals Group. 2004.

2. Cerner Multum, Inc. Australian Product Information.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.