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Cabazitaxel

Generic Name: Cabazitaxel (ca baz i TAKS el)
Brand Name: Jevtana

Warning

  • The bone marrow may not be able to make cells found in the blood as well as it used to for a few weeks. Sometimes, this has been deadly. Your white blood cell count will be watched closely while you are taking cabazitaxel. Talk with your doctor.
  • If you have a low white blood cell count, talk with your doctor. This medicine must not be used in people with certain low white blood cell counts.
  • Very bad and sometimes deadly allergic side effects have rarely happened. Talk with your doctor.
  • Other drugs may be given to help with infusion side effects.
  • Do not take this medicine if you are allergic to polysorbate 80.

Uses of Cabazitaxel:

  • It is used to treat prostate cancer.
  • It may be given to you for other reasons. Talk with the doctor.

What do I need to tell my doctor BEFORE I take Cabazitaxel?

  • If you have an allergy to cabazitaxel or any other part of cabazitaxel.
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you have liver disease.
  • If you are a woman. This medicine is not approved for use in women. If you are a woman using this medicine, talk with your doctor if you are pregnant, plan on getting pregnant, or are breast-feeding.

This is not a list of all drugs or health problems that interact with cabazitaxel.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this medicine with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Cabazitaxel?

  • Tell all of your health care providers that you take cabazitaxel. This includes your doctors, nurses, pharmacists, and dentists.
  • Avoid driving and doing other tasks or actions that call for you to be alert until you see how this medicine affects you.
  • You may have more of a chance of getting an infection. Wash hands often. Stay away from people with infections, colds, or flu. Some infections have been very bad and even deadly.
  • You may bleed more easily. Be careful and avoid injury. Use a soft toothbrush and an electric razor.
  • If you have upset stomach, throwing up, loose stools (diarrhea), or are not hungry, talk with your doctor. There may be ways to lower these side effects.
  • Have blood work checked as you have been told by the doctor. Talk with the doctor.
  • Very loose stools (diarrhea) and fluid and electrolyte problems have sometimes led to death in people taking cabazitaxel. Talk with your doctor.
  • Very bad and sometimes deadly stomach or bowel problems have happened with this medicine. This includes stomach or bowel bleeding, blockage, holes or tears, and swelling. Call your doctor right away if you have bloody stools, change in stool color, constipation, diarrhea, fever or chills, stomach pain, or stomach swelling. Call your doctor right away if you are throwing up or if any of your signs get worse or do not get better.
  • Very bad and sometimes deadly lung problems have happened with cabazitaxel. Call your doctor right away if you have lung or breathing problems that are new or worse like cough or shortness of breath.
  • Talk with your doctor before getting any vaccines. Use with this medicine may either raise the chance of an infection or make the vaccine not work as well.
  • If you are 65 or older, use cabazitaxel with care. You could have more side effects.
  • This medicine may affect being able to father a child. Talk with the doctor.
  • If you are a man and have sex with a female who could get pregnant, protect her from pregnancy during care and for 3 months after care ends. Use a condom.
  • If you are a man and your sex partner gets pregnant while you take this medicine or within 3 months after your last dose, call your doctor right away.
  • This medicine is not approved for use in women.
  • This medicine may cause harm to the unborn baby or loss of the unborn baby if you take it while you are pregnant.

How is this medicine (Cabazitaxel) best taken?

Use cabazitaxel as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • It is given as an infusion into a vein over a period of time.
  • Take with prednisone as you have been told by your doctor.
  • If you have not taken prednisone as you have been told, talk with your doctor.

What do I do if I miss a dose?

  • Call your doctor to find out what to do.

Dosage Information (comprehensive)

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of infection like fever, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, or wound that will not heal.
  • Signs of fluid and electrolyte problems like mood changes, confusion, muscle pain or weakness, a heartbeat that does not feel normal, very bad dizziness or passing out, fast heartbeat, more thirst, seizures, feeling very tired or weak, not hungry, unable to pass urine or change in the amount of urine produced, dry mouth, dry eyes, or very bad upset stomach or throwing up.
  • Signs of bleeding like throwing up blood or throw up that looks like coffee grounds; coughing up blood; blood in the urine; black, red, or tarry stools; bleeding from the gums; vaginal bleeding that is not normal; bruises without a reason or that get bigger; or any bleeding that is very bad or that you cannot stop.
  • Weakness on 1 side of the body, trouble speaking or thinking, change in balance, drooping on one side of the face, or blurred eyesight.
  • Dizziness or passing out.
  • Shortness of breath, a big weight gain, or swelling in the arms or legs.
  • A heartbeat that does not feel normal.
  • Feeling very tired or weak.
  • Very bad and sometimes deadly kidney problems have happened with this medicine. Call your doctor right away if you are unable to pass urine or if you have blood in the urine or a change in the amount of urine passed.

What are some other side effects of Cabazitaxel?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Headache.
  • Upset stomach.
  • Not hungry.
  • Weight loss.
  • Feeling tired or weak.
  • Back pain.
  • Bone or joint pain.
  • Hair loss.
  • Change in taste.
  • A burning, numbness, or tingling feeling that is not normal.
  • Muscle spasm.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

Side Effects (complete list)

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Cabazitaxel?

  • If you need to store cabazitaxel at home, talk with your doctor, nurse, or pharmacist about how to store it.

Consumer Information Use and Disclaimer

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Check with your pharmacist about how to throw out unused drugs.
  • Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about this medicine, please talk with your doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

This information should not be used to decide whether or not to take cabazitaxel or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to cabazitaxel. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine.

Review Date: December 6, 2017

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