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Cabazitaxel Dosage

Medically reviewed by Last updated on Jan 15, 2024.

Applies to the following strengths: 60 mg/1.5 mL

Usual Adult Dose for Prostate Cancer

20 mg/m2 IV over one-hour every three weeks


Use: In combination with prednisone for the treatment of patients with metastatic castration-resistant prostate cancer previously treated with a docetaxel-containing treatment regimen

Renal Dose Adjustments

CrCl 15 mL/min to less than 90 mL/min not requiring hemodialysis: No adjustment necessary
End stage renal dysfunction (CrCl less than 15 mL/min): Use with caution and monitor carefully during treatment.

Liver Dose Adjustments

Mild hepatic dysfunction (total bilirubin greater than 1 to 1.5 times upper limit of normal [x ULN] or AST greater than 1.5 x ULN): Maximum dose 20 mg/m2
Moderate hepatic dysfunction (total bilirubin greater than 1.5 to 3 x ULN and any AST): Maximum tolerated dose 15 mg/m2; however, efficacy of this dose is unknown
Severe hepatic dysfunction (total bilirubin greater than 3 x ULN): Contraindicated

Dose Adjustments

Dose modifications:

Adjust dosage for the following adverse events:

Adjust dosage for use with strong CYP450 3A inhibitors:





Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.


Data not available

Other Comments

Administration advice:

Storage requirements:

Reconstitution/preparation techniques: The manufacturer product information should be consulted.

IV compatibility: Do not mix with other medications.



Patient advice:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.