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Cabazitaxel Side Effects

Medically reviewed by Last updated on May 22, 2022.


Commonly reported side effects of cabazitaxel include: neutropenia, diarrhea, nausea, and vomiting. Other side effects include: febrile neutropenia, hypotension, and dehydration. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to cabazitaxel: intravenous solution


Intravenous route (Solution)

NeutropeniaNeutropenic deaths have been reported. Monitor for neutropenia with frequent blood cell counts. Cabazitaxel is contraindicated in patients with neutrophil counts of less than or equal to 1500 cells/mm(3). Primary prophylaxis with G-CSF is recommended in patients with high-risk clinical features. Consider primary prophylaxis with G-CSF in all patients receiving a dose of 25 mg/m(2).Severe HypersensitivitySevere hypersensitivity reactions can occur and may include generalized rash/erythema, hypotension and bronchospasm. Severe hypersensitivity reactions require immediate discontinuation of the cabazitaxel infusion and administration of appropriate therapy. Patients should receive premedication. Cabazitaxel is contraindicated in patients who have a history of severe hypersensitivity reactions to cabazitaxel or to drugs formulated with polysorbate 80.

Side effects requiring immediate medical attention

Along with its needed effects, cabazitaxel may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking cabazitaxel:

More common

  • Black, tarry stools
  • bleeding gums
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • blood in the urine or stools
  • burning, numbness, tingling, or painful sensations
  • chest pain
  • chills
  • cough
  • difficult or labored breathing
  • difficult or painful urination
  • fever
  • lower back or side pain
  • pale skin
  • pinpoint red spots on the skin
  • rapid weight gain
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • swollen glands
  • tightness in the chest
  • unsteadiness or awkwardness
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • unusual weight gain or loss
  • weakness in the arms, hands, legs, or feet

Less common

  • Blurred vision
  • confusion
  • decreased urination
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • dry mouth
  • fainting
  • fast, slow, or irregular heartbeat
  • lightheadedness
  • rapid breathing
  • sunken eyes
  • sweating
  • thirst
  • wrinkled skin

Incidence not known

  • Blue lips, fingernails, or skin
  • burning feeling in the chest or stomach
  • fast breathing
  • frequent urination
  • general feeling of discomfort or illness
  • indigestion
  • lower abdominal cramping
  • nausea
  • severe constipation
  • stomach pain or upset
  • tenderness in the stomach area
  • thickening of bronchial secretions
  • vomiting

Side effects not requiring immediate medical attention

Some side effects of cabazitaxel may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

  • Back pain
  • difficulty with moving
  • muscle pain, spasm, or stiffness
  • pain in the joints
  • pain, itching, burning, swelling, or a lump under your skin where the needle is placed

For Healthcare Professionals

Applies to cabazitaxel: intravenous solution


The most common adverse events were anemia, leukopenia, neutropenia, thrombocytopenia, and diarrhea.[Ref]


Very common (10% or more): Anemia (98%), leukopenia (96%), neutropenia (94%), thrombocytopenia (48%)

Common (1% to 10%): Febrile neutropenia[Ref]


Very common (10% or more): Diarrhea (47%), nausea (34%), vomiting (22%), constipation (20%), abdominal pain (17%), dyspepsia (10%)

Common (1% to 10%): Abdominal pain upper, hemorrhoids, gastroesophageal reflux disease, rectal hemorrhage, dry mouth, abdominal distension

Frequency not reported: Death related to diarrhea and electrolyte imbalance, GI hemorrhage and perforation, ileus, enterocolitis, neutropenic enterocolitis, colitis

Postmarketing reports: Gastritis, intestinal obstruction[Ref]

Nervous system

Very common (10% or more): Fatigue (37%), dysgeusia (11%)

Common (1% to 10%): Dizziness, peripheral neuropathy, headache, peripheral sensory neuropathy, paresthesia, lethargy, hypoesthesia, tinnitus, vertigo, sciatica

Frequency not reported: Peripheral motor neuropathy, fatal cerebral hemorrhage[Ref]


Very common (10% or more): Asthenia (20%), pyrexia (12%)

Common (1% to 10%): Mucosal inflammation, pain, death due to causes other than disease progression, malaise[Ref]


Very common (10% or more): Dyspnea (12%), cough (11%)

Common (1% to 10%): Oropharyngeal pain[Ref]


Common (1% to 10%): Peripheral edema, arrhythmia, hypotension, deep vein thrombosis, hypertension, tachycardia, grade 3 or higher arrhythmias, orthostatic hypotension, hot flush, flushing, atrial fibrillation

Uncommon (0.1% to 1%): Cardiac failure, cardiac arrest, fatal ventricular fibrillation[Ref]


Uncommon (0.1% to 1%): Grade 3 to 4 increased AST, grade 3 to 4 increased ALT, increased bilirubin

Frequency not reported: Fatal renal failure[Ref]


Very common (10% or more): Anorexia (16%)

Common (1% to 10%): Weight decreased, dehydration, edema, hyperglycemia, hypokalemia[Ref]


Very common (10% or more): Hematuria (17%)

Common (1% to 10%): Dysuria, pollakiuria, urinary retention, urinary incontinence, ureteric obstruction, pelvic pain[Ref]


Common (1% to 10%): AST increased, transaminases increased

Uncommon (0.1% to 1%): ALT increased, bilirubin increased[Ref]


Common (1% to 10%): Hypersensitivity[Ref]


Very common (10% or more): Back pain (16%), arthralgia (10.5%)

Common (1% to 10%): Pain in extremity, muscle spasms, myalgia, musculoskeletal chest pain, flank pain, chills[Ref]


Common (1% to 10%): Urinary tract infection, influenza, cystitis, upper respiratory tract infection, pneumonia, cellulitis, herpes zoster, septic shock, sepsis, candidiasis

Uncommon (0.1% to 1%): Neutropenic sepsis, neutropenic infections

Frequency not reported: Fatal infection[Ref]


Very common (10% or more): Alopecia (10%)

Common (1% to 10%): Dry skin, erythema[Ref]


Common (1% to 10%): Conjunctivitis, increased lacrimation[Ref]


Common (1% to 10%): Anxiety, confusional state[Ref]


1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. "Product Information. Jevtana (cabazitaxel)." sanofi-aventis (2010):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.