Mitotic inhibitors are drugs derived from natural plant sources. They inhibit cell division or mitosis, where a single cell divides into two genetically identical daughter cells. Mitotic inhibitors bind to tubulin and inhibit its polymerization into microtubules. Microtubules are structures responsible for pulling the cell apart when it divides.
Mitotic inhibitors affect cancer cells more than normal cells because cancer cells divide (mitotic cell division) more rapidly therefore are more susceptible to mitotic inhibition.
Subscribe to receive email notifications whenever new articles are published.
Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include Micromedex® (updated Apr 12th, 2018), Cerner Multum™ (updated Apr 5th, 2018), Wolters Kluwer™ (updated Apr 6th, 2018) and others. To view content sources and attributions, please refer to our editorial policy.