Generic Name: ticagrelor (tye-KA-grel-or)
Brand Name: Brilinta
Brilinta can cause serious and sometimes fatal bleeding problems. Do not use Brilinta if you have an active bleeding problem or a history of bleeding in the brain.
Tell your doctor if you have recently had surgery or if you are scheduled to have surgery. You may need to stop taking Brilinta before you have surgery. Try to stop at least 5 days before any surgery. Do not stop taking Brilinta without checking with your doctor. This may increase the risk of certain heart problems. If you need to stop taking Brilinta, follow your doctor's directions carefully. Discuss any questions or concerns with your doctor.
Brilinta should be taken along with aspirin. Do not take more than 100 mg of aspirin a day. Taking doses of aspirin that are higher than the dose recommended while you are taking Brilinta may decrease Brilinta's effectiveness.
Brilinta is used for:
Reducing the risk of stroke, heart attack, or death in certain patients who have had a heart attack or who have angina (chest pain). It should be used along with aspirin as directed by your doctor. It also may be used for other conditions as determined by your doctor.
Brilinta is a platelet aggregation inhibitor. It works by slowing or stopping platelets from sticking to blood vessel walls or injured tissues.
Do NOT use Brilinta if:
- you are allergic to any ingredient in Brilinta
- you have an active bleeding problem (eg, bleeding stomach ulcer, bleeding in the brain) or a history of bleeding in the brain
- you have severe liver problems
- you are taking certain azole antifungals (eg, itraconazole, ketoconazole, voriconazole), carbamazepine, dexamethasone, certain macrolide antibiotics (eg, clarithromycin), nefazodone, phenobarbital, phenytoin, certain protease inhibitors (eg, atazanavir, ritonavir), rifampin, or telithromycin
Contact your doctor or health care provider right away if any of these apply to you.
Before using Brilinta:
Some medical conditions may interact with Brilinta. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have liver or kidney problems, lung or breathing problems (eg, asthma, chronic obstructive pulmonary disease [COPD]), recent stomach or bowel bleeding, or a history of ulcers or bowel polyps
- if you have had a recent injury or surgery, including dental surgery; if you will be having surgery or a dental procedure; or if you are on dialysis
- if you have certain irregular heartbeat problems (eg, sick sinus syndrome, second- or third-degree heart block), or you have fainting caused by slow heartbeat and you do not have a permanent pacemaker
- if you have a history of bleeding or clotting problems, stroke, gouty arthritis, or high blood uric acid levels
- if you have received medicine to dissolve a blood clot (eg, alteplase) within 24 hours of taking Brilinta
- if you take another medicine to prevent or treat blood clots
Some MEDICINES MAY INTERACT with Brilinta. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Anticoagulants (eg, heparin, warfarin), direct thrombin inhibitors (eg, dabigatran, desirudin), nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, celecoxib, ibuprofen), rivaroxaban, or salicylates (eg, aspirin) because the risk of bleeding may be increased
- Azole antifungals (eg, fluconazole, ketoconazole, voriconazole), macrolide antibiotics (eg, clarithromycin, erythromycin), nefazodone, protease inhibitors (eg, amprenavir, atazanavir, ritonavir), or telithromycin because they may increase the risk of Brilinta's side effects
- Carbamazepine, dexamethasone, efavirenz, hydantoins (eg, phenytoin), phenobarbital, primidone, rifamycins (eg, rifampin), or St. John's wort because they may decrease Brilinta's effectiveness
- Digoxin, lovastatin, or simvastatin because the risk of their side effects may be increased by Brilinta
This may not be a complete list of all interactions that may occur. Ask your health care provider if Brilinta may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Brilinta:
Use Brilinta as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Brilinta comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Brilinta refilled.
- Take Brilinta by mouth with or without food.
- If you cannot swallow the tablet whole, the tablet can be crushed and mixed with water. Drink right away after mixing. Refill the glass with water, stir, and drink.
- People who have feeding tubes may use the tablet. Crush the tablet and mix it with water. Flush the feeding tube after Brilinta is given.
- Take at the same time each day.
- To gain the most benefit, do not miss doses.
- If you miss a dose of Brilinta, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Brilinta.
Important safety information:
- Tell your doctor or dentist that you take Brilinta before you receive any medical or dental care, emergency care, or surgery. You may need to stop Brilinta before you have certain types of surgery.
- Do not exceed the dose of aspirin recommended by your doctor while you are taking Brilinta. Before you start any new medicine, check the label to see if it has aspirin in it too. If it does or if you are not sure, check with your doctor or pharmacist.
- Brilinta reduces the action of the clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.
- Use Brilinta with caution in the ELDERLY; they may be more sensitive to its effects, especially bleeding problems.
- PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of taking Brilinta while you are pregnant. It is not known if this medicine is found in breast milk. Do not breast-feed while taking Brilinta.
Possible side effects of Brilinta:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if you have any side effects that persist or become bothersome. Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); bleeding in the eye; chest pain; fainting; fast, slow, or irregular heartbeat; light-headedness; purple skin patches; shortness of breath; symptoms of stroke (eg, sudden numbness or weakness of an arm, leg, or the face; one-sided weakness; sudden confusion, trouble speaking, or trouble understanding others; loss of balance, coordination, or trouble walking; sudden severe headache or dizziness with no known cause); symptoms of bleeding (eg, vomiting blood or vomit that looks like coffee grounds; coughing up blood; blood in the urine; black, red, or tarry stools; bleeding from the gums; unusual vaginal bleeding; bruises without a reason or that get bigger; any bleeding that is severe or that you cannot stop).
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.Proper storage of Brilinta:
Store Brilinta at room temperature, between 59 and 86 degrees F (15 and 30 degrees C) in its original container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Brilinta out of the reach of children and away from pets.
- If you have any questions about Brilinta, please talk with your doctor, pharmacist, or other health care provider.
- Brilinta is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take Brilinta or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Brilinta. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Brilinta. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Brilinta.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.
More about Brilinta (ticagrelor)
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Images
- Drug Interactions
- Support Group
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- Drug class: platelet aggregation inhibitors