MEFENAMIC ACID 500 MG FILM-COATED TABLETS
Active substance(s): MEFENAMIC ACID / MEFENAMIC ACID
Your medicine is known by the above name but will be referred to as Mefenamic
Tablets throughout this leaflet.
Read all of this leaflet carefully before you start using this medicine.
• Keep this leaflet. You may need to read it again.
• If you have any further questions, ask your doctor or pharmacist.
• This medicine has been prescribed for you. Do not pass it on to others. It may harm them, even if their symptoms are the same as
• If any of the side effects get serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.
In this leaflet:
1. What this medicine is and what it is used for
2. Before you take
3. How to take
4. Possible side effects
5. How to store
6. Further information
1. What this medicine is and what
it is used for
Mefenamic Tablets contain mefenamic acid which is a
non-steroidal anti-inflammatory drug (NSAID).
They can help to relieve:
• symptoms of inflammation, such as redness and swelling
• pain and discomfort caused by arthritis, muscular or
• headache, muscle ache or toothache
• pain after operations, trauma
• childbirth pain
• painful or heavy periods.
2. Before you take
Do NOT take Mefenamic Tablets if you:
• are allergic to mefenamic acid, to any other anti-inflammatory
medicines (such as aspirin, ibuprofen, celecoxib), or to any of
the other ingredients (see Section 6)
• have, or have ever had, stomach or intestinal conditions such
as peptic ulcer, bleeding in the stomach or severe gastritis
• have an inflammatory bowel disease (e.g. ulcerative colitis,
• have severe heart, liver or kidney problems
• have just had heart bypass surgery
• are more than 6 months pregnant.
If any of the above apply to you, speak to your doctor or
Take special care with Mefenamic Tablets
Before taking the tablets, tell your doctor if you:
• are taking any other NSAIDs (e.g. ibuprofen, diclofenac)
• are taking any other anti-inflammatory medicines including
steroids (e.g. prednisolone)
• are taking aspirin or medicines that thin the blood (e.g.
• are taking antidepressants called selective serotonin reuptake inhibitors (SSRIs) (e.g. paroxetine)
• have kidney or liver problems. Your doctor may check your
kidney or liver function before and during treatment
• are elderly (see Section 3)
• are trying to become pregnant (see Section on Fertility)
• have stomach or digestive tract problems or if you ever had
an upset stomach after taking pain killers such as aspirin.
Bleeding in the stomach or gut can occur in patients taking
• have a bleeding disorder or if you are going to have a major
operation. Mefenamic Tablets can affect the clotting of your
blood. It can make you bleed more and for longer than usual
• have asthma, or a history of asthma, as this medicine may
cause breathing difficulties
• have a connective tissue disorder, e.g. Systemic Lupus
• have epilepsy
• are dehydrated (thirsty with dry skin, dark urine, dry mouth,
• have heart problems, previous stroke or think that you might
be at risk of these conditions (e.g. if you have high blood
pressure, diabetes or high cholesterol or are a smoker).
Additional monitoring may be carried out by your doctor.
Medicines such as Mefenamic Tablets may be associated
with a small increased risk of heart attack or stroke. Any risk is
more likely with high doses and prolonged treatment. Do not
exceed the recommended dose or duration of treatment.
Taking other medicines
Please tell your doctor or pharmacist if you are taking or have
recently taken any other medicines, including medicines obtained
without a prescription, and herbal preparations.
Some medicines may be affected by Mefenamic Tablets or
they may affect how well Mefenamic Tablets will work. Tell your
doctor or pharmacist if you are taking:
• medicines that can increase the chance of getting ulcers or a
bleed in the stomach or gut, such as:
--corticosteroids used to treat arthritis and inflammation
--medicines such as anti-platelet agents, used to thin the
blood (e.g. warfarin, aspirin, clopidogrel)
--antidepressants called selective serotonin re-uptake
inhibitors (SSRIs) (e.g. paroxetine)
--any other anti-inflammatory medicines (e.g. diclofenac,
• aspirin including low doses of aspirin used to prevent your
blood from clotting in certain heart conditions.
• medicines used for high blood pressure (e.g. atenolol,
• diuretics (water tablets) or heart medicines (e.g. digoxin,
• some diabetic medicines (e.g. glipizide, glibenclamide)
• medicines which suppress the immune system (e.g.
ciclosporin, tacrolimus, methotrexate)
• lithium, a medicine used to treat mood swings and some
types of depression
• a medicine usually prescribed through hospitals, called
mifepristone (taken within the last 12 days)
• quinolone antibiotics (antibiotics used to treat infections)
• aminoglycoside antibiotics, used under medical supervision
• zidovudine, a medicine used for HIV
• probenecid, a medicine used in special cases, to protect the
• medicines which bind to protein in the blood - (check with
Your doctor may test your blood during treatment.
Pregnancy and breast-feeding
Mefenamic acid will be passed to your unborn baby. It is not
known how much it will affect your unborn baby in the first
6 months of pregnancy.
DO NOT take the tablets in the last 3 months of pregnancy as
they may delay the onset of labour and prolong its duration.
They may also increase the likelihood of bleeding in the mother
and in the baby.
If you need to take these tablets, your doctor can help you
decide whether or not to take them during the first 6 months of
Mefenamic acid passes into breast milk and can affect the
baby. You should not take the tablets while breast-feeding
unless advised by your doctor.
DO NOT take the tablets if you are trying to become pregnant,
as they may make it more difficult to get pregnant. You should
inform your doctor if you are planning to become pregnant or if
you have problems becoming pregnant.
Ask your doctor for advice before taking any medicine.
Driving and using machines
Mefenamic Tablets may cause drowsiness, dizziness, fatigue
or affect your vision. If any of these occur do not drive, use
machinery, or perform any tasks that may require you to be alert.
Important information about some of the ingredients of
If you have been told by your doctor that you have an
intolerance to some sugars, contact your doctor before taking
• sunset yellow
This may cause allergic reactions.
Continued over page
3. How to take
Always take Mefenamic Tablets exactly as your doctor has
told you and always read the label. Your doctor will decide on
the appropriate dose to suit your condition. Ask your doctor or
pharmacist if you are not sure.
• Take the tablets with or immediately after a meal.
• Do NOT drink alcohol while taking Mefenamic Tablets.
Alcohol and smoking can irritate the stomach and make some
of the side effects worse.
Adults and the elderly: the usual dose is 1 tablet three times
Elderly patients are at a higher risk of side effects and should
take the lowest effective dose for the shortest possible time,
with additional monitoring carried out by their doctor.
Children: this medicine is NOT suitable for children under 12
If you take more than you should
If you take more tablets than you should you may harm your
stomach, kidneys and you may get seizures (fits).
1. Tell your doctor, pharmacist or nearest hospital casualty
2. Take the container and any remaining tablets with you so
that people can see what you have taken.
3. Do this even if you feel well.
If you forget to take
If you forget to take a dose take it as soon as you remember, but
if it is almost time for your next dose, skip the missed dose and
continue as usual.
Do not use a double dose to make up for a missed dose.
If you have any further questions on the use of this product, ask
your doctor or pharmacist
4. Possible side effects
Like all medicines, Mefenamic Tablets can cause side effects,
although not everybody gets them. Do not be alarmed by this list
of possible side effects. You may not experience any of them.
Tell your doctor if you get any of the following side effects:
• head-spins (vertigo)
• fatty stools
• inability to sleep
• rapid heartbeat (palpitations)
• mental confusion
• loss of appetite
• ear pain
• constipation or bloating
• blurred vision, eye irritation
• feeling ill (malaise)
• ringing or buzzing in the ears (tinnitus)
• numbness or tingling in hands or feet
• sudden poor blood sugar control if you have
diabetes. Your doctor or pharmacist can
measure your sugar levels
• asthma or asthma that is worse than usual
• swelling of your hands and feet (around the ankles)
• sore mouth (pain or ulcers on the tongue, cheeks, lips, throat
• dizziness, drowsiness, feeling lethargic and tired
• signs of low blood pressure such as light-headedness
• reactions to the sun. Your skin may become red, painful and
swollen - do not sunbathe, use a sun bed, or expose your
skin to artificial UV light.
Medicines such as Mefenamic Tablets may be associated with a
small increased risk of heart attack or stroke. (See Section 2 - end
of ‘Take special care’).
Urine tests: Tell the doctor if you are having urine tests, as your
medicine may affect the results.
Reporting of side effects
If you get any side effects, talk to your doctor, pharmacist or
nurse. This includes any possible side effects not listed in this
leaflet. You can also report side effects directly via the Yellow
Card Scheme at: www.mhra.gov.uk/yellowcard
By reporting side effects you can help provide more information
on the safety of this medicine.
5. How to store
STOP taking the tablets and seek medical help immediately if
you have any of the following allergic reactions:
• difficulty breathing or swallowing, swelling of the face, lips,
tongue or throat
• severe itching of the skin, with a red rash or raised lumps
• blistering of the mouth, eyes, and genital region, and patchy
areas of rash, peeling skin
or any of the following reactions
• passing blood in your stools (faeces/motions)
• passing black tarry stools
• vomiting any blood or dark particles that look like coffee
Keep out of the sight and reach of children.
Do not store above 30°C. Store in the original package.
Do not use your tablets after the expiry date which is stated on
the carton and blister. The expiry date refers to the last day of
If your tablets become discoloured or show signs of deterioration
seek the advice of your pharmacist who will tell you what to do.
Seek immediate medical attention if you have any of the
• indigestion or heartburn, abdominal pain (pain in your
stomach) or other abnormal stomach symptoms, nausea
(feeling sick), vomiting
• any unusual bruising or bleeding, for example nose-bleeds,
pinpoint red spots on the skin, unusual purple bruise-like
rash on the skin or in the mouth
• signs of anaemia such as feeling tired, breathless, and
• fever, sore throat, mouth ulcers, repeated infections or
infections that will not go away. This may be due to a low
level of white blood cells
• seizures (fits)
• signs of low sodium levels such as headache, nausea,
vomiting, tiredness, muscle cramps
• sudden headache, stiff neck, fever, sensitivity to bright light,
drowsiness and muscle pain, with or without a rash
• fever, rash, nausea, aches and pains, passing more or less
urine than usual, passing red urine or passing urine at night.
This may be due to changes in your kidneys
• sudden loss or blurring of vision, loss of colour vision, eye
pain which worsens with eye movement
• headache, in particular on waking in the morning. This may
be due to high blood pressure
• pain behind the ribs radiating towards the back, often worse
when lying down, nausea, vomiting, fever. This may be due
to inflammation of your pancreas
• yellowing of your skin or eyes, pale faeces and dark urine,
unexplained persistent nausea, stomach problems, loss of
appetite or unusual tiredness. This may be due to changes
in your liver.
What Mefenamic Tablets contain
Medicines should not be disposed of via wastewater or
household waste. Ask your pharmacist how to dispose of
medicines that are no longer required. This will help to protect
6. Further information
Each tablet contains 500mg mefenamic acid.
Also includes lactose monohydrate, pregelatinised maize
starch, maize starch, povidone, silicon dioxide, talc, magnesium
stearate, croscarmellose sodium type A, sodium laurilsulfate.
The film-coating contains hypromellose, titanium dioxide (E171),
lactose monohydrate, macrogol 4000, vanillin, quinoline yellow
(E104), sunset yellow (E110).
The polish contains purified water, beeswax, carnauba wax
yellow, polysorbate 20 and sorbic acid (E200).
(See end of Section 2 for further information on lactose and
What Mefenamic Tablets look like and contents of the pack
Yellow, film-coated tablets marked ‘PONSTAN FORTE’ on one
side and plain on the reverse.
Available in blister packs of 30 tablets
Who manufactured your medicine
Manufactured by Dales Pharmaceuticals Ltd, Snaygill Industrial
Estate, Keighley Road, Skipton, BD23 2RW, UK.
Procured from within the EU and repackaged by Product Licence
holder Ennogen Healthcare Ltd, Unit G4 Riverside Industrial
Estate, Riverside Way, Dartford, Kent, DA1 5BS.
Leaflet date: 20 January 2017
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Ponstan and Chemidex are registered trademarks of Chemidex
Source: Medicines and Healthcare Products Regulatory Agency
Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.