DIAMOX 250MG TABLETS
Active substance(s): ACETAZOLAMIDE / ACETAZOLAMIDE / ACETAZOLAMIDE
Diamox® 250mg Tablets
Read all of this leaflet carefully before you start taking this medicine.
Keep this leaflet. You may need to read it again. If you have any further questions, ask your doctor or pharmacist. This
medicine has been prescribed for you. Do not pass it on to others. It may harm them, even if their symptoms are the same
as yours. If any of the side effects become serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or
What Diamox 250mg Tablets are and what they are used for
Before you take Diamox 250mg Tablets
How to take Diamox 250mg Tablets
Possible side effects
How to store Diamox 250mg Tablets
1. WHAT DIAMOX 250MG TABLETS ARE AND WHAT THEY ARE USED FOR
Diamox 250mg Tablets (referred to as Diamox 250mg Tablets throughout this leaflet) contain the active substance
Acetazolamide. This belongs to a group of medicines known as carbonic anhydrase inhibitors.
Diamox 250mg Tablets are used to treat:
• glaucoma (a condition of the eye), by reducing the pressure within the eye
• abnormal retention of fluids (Diamox 250mg Tablets acts as a diuretic)
• epilepsy (fits or convulsions).
2. BEFORE YOU TAKE DIAMOX 250MG TABLETS
DO NOT take Diamox 250mg Tablets if:
• you know you are allergic to sulphonamides, sulphonamide derivatives including acetazolamide or to any of the
ingredients in the medicine (listed in Section 6 at the end of this leaflet)
• you have severe liver problems
• you have or have ever had severe kidney problems
• you have a particular type of glaucoma known as chronic non congestive angle closure glaucoma (your doctor will be able to advise
• you have reduced function of the adrenal glands – glands above the kidneys – (also known as Addison’s disease)
• you have low blood levels of sodium and/or potassium or high blood levels of chlorine (your doctor will advise you).
Speak to your doctor if any of the above applies to you.
Take special care and speak to your doctor before taking Diamox 250mg Tablets if:
• you have or have ever had kidney problems such as kidney stones
• you have lung problems such as chronic bronchitis or emphysema, which cause difficulty in breathing
• you are over the age of 65
• a small number of people being treated with anti-epileptics such as Acetazolamide have had thoughts of harming or killing
themselves, if at any time you have these thoughts, immediately contact your doctor.
Diamox 250mg Tablets may affect some medical tests. If you visit a hospital or clinic for any medical tests, you should tell the
doctor concerned that you are taking Diamox 250mg Tablets.
Taking other medicines:
Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained
without a prescription. The effects of any of these medicines may change, particularly if you are taking, or using, any of the following:
• medicines for your heart such as cardiac glycosides (e.g. digoxin)
• medicines to reduce blood pressure
• medicines to thin your blood (e.g. warfarin)
• medicines to lower the sugar in your blood (e.g. metformin, gliclazide)
• medicines for epilepsy or fits (in particular, phenytoin, primidone or carbamazepine or topiramate)
• drugs which interfere with folic acid, e.g. methotrexate, pyrimethamine, or trimethoprim
• steroids such as prednisolone
• aspirin and related medicines, e.g. salicylic acid or choline salicylate for mouth ulcers
• other drugs in the group of medicines called carbonic anhydrase inhibitors (e.g. dorzolamide or brinzolamide which are
also used to treat glaucoma)
• amphetamines (a stimulant), quinidine (treats an irregular heart beat), methenamine (prevents urine infections) or lithium
(treats severe mental problems)
• sodium bicarbonate therapy (used to treat high states of acid in your body)
• ciclosporin (used to suppress the immune system).
Pregnancy and breast feeding:
Ask your doctor or pharmacist for advice before taking any medicines.
Diamox 250mg Tablets SHOULD NOT be taken if you are pregnant, think you are pregnant or are planning to become pregnant.
It may be taken when breast feeding but only on the advice of the doctor.
Driving and using machines:
If Diamox 250mg Tablets make you feel drowsy or confused you should not drive or operate machines. Diamox 250mg Tablets
can occasionally cause short-sightedness; if this happens and you feel that you can no longer drive safely, you should stop
driving and contact your doctor.
3. HOW TO TAKE DIAMOX 250MG TABLETS
• Always take the number of tablets your doctor has told you to take. This information will also be on the label.
• Diamox 250mg Tablets should be swallowed whole with a drink of water, just before or just after a meal. Do not chew or
crush the tablets.
• The dose varies from person to person depending on their condition. Your doctor will decide on the most appropriate
dose. If you are not sure how many tablets to take or when to take them, ask your doctor or pharmacist.
Adults: 250mg-1000mg (1-4 tablets) every 24 hours, in divided doses.
Retention of fluid:
Adults: starting dose is 250-375mg (1-1.5 tablets) once daily in the morning. Your doctor will adjust the dose and tell you how
often to take your dose.
Adults: 250-1000mg daily in divided doses.
Children: the dose will depend on the bodyweight of the child, to be taken in divided doses. Dose should not be more than
750mg (3 tablets) per day.
• Before starting and during treatment your doctor may monitor your blood to check that treatment with Diamox 250mg Tablets
is suitable for you.
If you take more Diamox 250mg Tablets than you should:
Get medical help immediately, either by calling your doctor or going to the nearest hospital casualty department. Take any
remaining tablets and this leaflet with you so that the medical staff know exactly what you have taken.
If you forget to take your Diamox 250mg Tablets:
You should take it as soon as you remember. However, if this is within two hours of your next dose you should skip the missed
tablets and carry on taking the rest of your tablets as usual.
DO NOT take a double dose of tablets to make up the missed dose.
If you have any further questions about these tablets, ask your doctor or pharmacist.
4. POSSIBLE SIDE EFFECTS
Like all medicines, Diamox 250mg Tablets can cause side effects, although not everybody gets them.
All medicines can cause allergic reactions although serious allergic reactions are very rare. Any sudden
wheeziness, difficulty in breathing, swelling of the eyelids, face or lips, rash or itching (especially affecting your
whole body) should be reported to a doctor immediately.
Extremely rarely, Diamox 250mg Tablets can affect the cells in your blood. This could mean that you are more likely to catch
infections and that your blood may not clot properly. If you have a sore throat or fever or you notice bruises or tiny red or purple
spots on your skin you should contact your doctor immediately. If your muscles feel weak or you have fits, you should see your
Very rarely, Diamox 250mg Tablets can affect the liver and kidneys. If you experience pain in your lower back, pain or burning
when you pass urine, have difficulty in passing urine, or you stop passing urine, have blood in your urine, pale stools, or if your
skin or eyes look slightly yellow, you should contact your doctor. You should also contact your doctor if your stools are black
or tarry, or if you notice blood in your stools.
Common side effects are:
• feeling or being sick, loss of appetite, thirst, or a metallic taste in the mouth
• dizziness, loss of full control of arms or legs
• looking flushed
• a need to pass urine more often than normal
• tiredness or irritability
• feeling over-excited
• a tingling or numbness in the fingers or toes, or coldness in the extremities.
Uncommon side effects are:
• drowsiness or confusion
• a loss of interest in sex
• ringing in the ears or difficulty in hearing
• temporary short-sightedness which subsides when the dosage is reduced or treatment is stopped.
Rare cases of skin rashes including an increased sensitivity to sunlight have been reported. If you experience any unusual
skin rashes, inform your doctor.
If you take Diamox 250mg Tablets for a long time it can occasionally affect the amount of potassium, or sodium in your blood.
Your doctor will probably take blood tests to check that this does not happen. You might also experience bone thinning or the
risk of kidney stones with long-term therapy. High or low blood sugar levels may occasionally occur.
If any of the side effects becomes serious, or if you notice any side effects not listed in this leaflet, please tell your
doctor or pharmacist.
Reporting of side effects:
If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in
this leaflet. You can also report side effects directly via the Yellow Card Scheme at: www.mhra.gov.uk/yellowcard.
By reporting side effects you can help provide more information on the safety of this medicine
5. HOW TO STORE DIAMOX 250MG TABLETS
Do not store above 25oC. Store in the original pack or in containers which prevents the access of moisture.
Keep this medicine out of the sight and reach of children.
Do not use after the expiry date. This date is printed on your pack. The Expiry date refers to last day of that month.
Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no
longer required. These measures will help to protect the environment.
This medicine is for you. Only a doctor can prescribe it for you. Never give this medicine to someone else; it could harm them,
even if their symptoms seem the same as yours.
6. FURTHER INFORMATION
What Diamox 250mg Tablets Contain:
The active substance is acetazolamide. Each tablet contains 250mg acetazolamide.
The other ingredients are dicalcium phosphate, corn starch, magnesium stearate, sodium starch glycolate, povidone.
What Diamox 250mg Tablets look like and contents of the pack:
Diamox 250mg Tablets are white, round, convex tablets with “FW 147” on one side and scored in quarters on the other. They
usually come in amber glass bottles with metal screw on caps or plastic bottles with plastic caps, containing 112 tablets.
Marketing Authorisation Holder: Mercury Pharmaceuticals Ltd., Capital House, 85 King William Street, London EC4N 7BL, UK
Manufacturer: Custom Pharmaceuticals Limited, Conway Street, Hove, East Sussex, BN3 3LW, UK
This leaflet was last revised in September 2014.
Mercury Pharma Group Ltd. is licensed to use the registered trademark Diamox
Source: Medicines and Healthcare Products Regulatory Agency
Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.