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Acetazolamide Dosage

Applies to the following strength(s): 500 mg ; 125 mg ; 250 mg

The information at is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for Edema

250 to 375 mg oral or IV once a day.

When continued acetazolamide therapy for edema is desired, it is recommended that every second or third dose be skipped to allow the kidney to recover.

Usual Adult Dose for Acute Mountain Sickness

Oral tablet: 125 to 250 mg orally every 6 to 12 hours.
SR capsule: 500 mg orally every 12 to 24 hours.

The maximum recommended dose is 1 gram/day.
For rapid ascent, higher doses are beneficial for preventing acute mountain sickness beginning 24 to 48 hours before ascent and continuing for 48 hours while at high altitude.

Usual Adult Dose for Glaucoma

Open-angle Glaucoma:

tablet or IV injection: 250 mg 1 to 4 times a day.
- or-
SR capsule: 500 mg once or twice a day.

Closed-angle glaucoma:

250 to 500 mg IV, may repeat in 2 to 4 hours to a maximum of I gram/day.

Usual Adult Dose for Seizure Prophylaxis

8 to 30 mg/kg/day in 1 to 4 divided doses. Do not exceed 1 gram per day.

If this patient is already taking other anticonvulsants, the recommended starting dosage is 250 mg once a day. If acetazolamide is used alone, most patients with good renal function respond to daily doses ranging from 375 to 1000 mg. The optimum dosage for this patient with renal dysfunction is not known, and will depend on this patient's clinical response and tolerance.

Acetazolamide is primarily used for the treatment of refractory epilepsy in combination with other drugs. Although it may be useful in partial, myoclonic, absence, and primary generalized tonic-clonic seizures uncontrolled by other marketed agents, it has been inadequately studied by current standards for these conditions.

Usual Pediatric Dose for Glaucoma

>= 1 year:

Oral: 8 to 30 mg/kg/day or 300 to 900 mg/m²/day divided every 8 hours.
IV: 20 to 40 mg/kg/day divided every 6 hours.

Maximum dose: 1 gram/day.

Usual Pediatric Dose for Edema

>= 1 year:

Oral or IV: 5 mg/kg or 150 mg/m² once a day.

Usual Pediatric Dose for Epilepsy

>= 1 year:

Oral: 8 to 30 mg/kg/day in 1 to 4 divided doses. Maximum dose is 1 gram/day.

Usual Pediatric Dose for Hydrocephalus


Oral or IV: 20 to 100 mg/kg/day divided every 6 to 8 hours. Maximum dose is 2 grams/day.

Renal Dose Adjustments

CrCl < 10 mL/min: Not recommended.

CrCl 10 to 50 mL/min: The dosage interval should be doubled.

Liver Dose Adjustments

Not recommended for patients with severe liver disease. Patients with mild liver disease should be monitored carefully.


Acetazolamide is moderately dialyzable (20 to 50%).