Acetazolamide Side Effects
For the Consumer
Applies to acetazolamide: oral capsules, oral tablets, parenteral powder for injection
Side effects include:
Paresthesias, hearing dysfunction or tinnitus, anorexia, altered taste, nausea, vomiting, diarrhea, polyuria, drowsiness, confusion.
For Healthcare Professionals
Applies to acetazolamide: compounding powder, injectable powder for injection, intravenous powder for injection, oral capsule extended release, oral tablet
Adverse reactions occurring early in therapy have included paresthesias, tinnitus, nausea, vomiting, diarrhea, and drowsiness.[Ref]
Frequency not reported: Anaphylactic/anaphylactoid reactions including shock and fatalities[Ref]
Frequency not reported: Blood dyscrasias such as aplastic anemia, agranulocytosis, leucopenia, thrombocytopenia, and thrombocytopenia purpura[Ref]
Frequency not reported: Loss of appetite, electrolyte disturbances, metabolic acidosis and hypokalemia with long term therapy, hyponatremia osteomalacia with long-term therapy, hyper/hypoglycemia[Ref]
Rare (0.01% to 0.1%): Photosensitivity
Frequency not reported: Skin reactions, Stevens-Johnson syndrome, toxic epidermal necrolysis, urticaria, rash including erythema multiforme[Ref]
Frequency not reported: Nausea, vomiting, diarrhea, melena[Ref]
Frequency not reported: Abnormal liver function, cholestatic jaundice, fulminant hepatic necrosis, hepatitis[Ref]
Very common (10% or more): Paresthesias (up to 20%)
Frequency not reported: Drowsiness, headache, dizziness, taste alteration, ataxia, flaccid paralysis, convulsions, sensory disturbances[Ref]
Frequency not reported: Confusion, irritability, depression, excitement, reduced libido[Ref]
Frequency not reported: Transient myopia[Ref]
Frequency not reported: Renal colic, increased risk of nephrolithiasis, renal failure[Ref]
Frequency not reported: Polyuria, polydipsia, crystalluria, renal calculi, hematuria, glycosuria[Ref]
Frequency not reported: Growth retardation in children[Ref]
Frequency not reported: Flushing, malaise, thirst, fatigue, fever, hearing disturbances[Ref]
Frequency not reported: Injection site pain[Ref]
1. "Product Information. Diamox Sequels (acetaZOLAMIDE (acetazolamide))." Barr Pharmaceuticals Inc, Pomona, NY.
2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
3. "Product Information. Acetazolamide for Injection (acetaZOLAMIDE (acetazolamide))." Sterimax Inc, Kingston, OR.
4. "Product Information. AcetaZOLAMIDE (acetaZOLAMIDE (acetazolamide))." Taro Pharmaceuticals U.S.A. Inc, Hawthorne, NY.
5. Cerner Multum, Inc. "Australian Product Information." O 0
Some side effects of acetazolamide may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
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