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Vancocin HCl Pulvules Side Effects

Generic name: vancomycin

Medically reviewed by Last updated on Dec 13, 2023.

Note: This document contains side effect information about vancomycin. Some dosage forms listed on this page may not apply to the brand name Vancocin HCl Pulvules.

Applies to vancomycin: oral capsule, oral powder for solution, oral powder for suspension. Other dosage forms:

Serious side effects

Along with its needed effects, vancomycin (the active ingredient contained in Vancocin HCl Pulvules) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking vancomycin:

More common

Less common


Incidence not known

Other side effects

Some side effects of vancomycin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Incidence not known

For Healthcare Professionals

Applies to vancomycin: compounding powder, intravenous powder for injection, intravenous solution, oral capsule, oral powder for reconstitution, oral solution.


The most commonly reported side effects include nausea, abdominal pain, and hypokalemia.[Ref]


Very common (10% or more): Nausea (up to 17%), abdominal pain (up to 15%)

Common (1% to 10%): Vomiting, diarrhea, flatulence

Uncommon (0.1% to 1%): Mild gastrointestinal tract disturbances

Very rare (less than 0.01%): Pseudomembranous enterocolitis/colitis

Frequency not reported: Chemical peritonitis, constipation, indigestion, stomachache[Ref]

Chemical peritonitis occurred with intraperitoneal administration.

Mild gastrointestinal tract disturbances occurred with oral administration.[Ref]


Very common (10% or more): Hypokalemia (up to 13%)[Ref]


Common (1% to 10%): Exanthema, pruritus, vancomycin (the active ingredient contained in Vancocin HCl Pulvules) infusion reaction, redness of the face/upper arms, urticaria

Uncommon (0.1% to 1%): Erythema, itch

Rare (0.01% to 0.1%): Toxic epidermal necrolysis

Very rare (less than 0.01%): Exfoliative dermatitis, linear IgA bullous dermatosis, Lyell's syndrome, Stevens-Johnson syndrome

Frequency not reported: Acute generalized exanthematous pustulosis (AGEP), erythematous macular rash with intense pruritus over face/neck/upper body, rash, red neck[Ref]


Common (1% to 10%): Decrease in blood pressure, flushing of the upper body, peripheral edema, phlebitis

Uncommon (0.1% to 1%): Thrombophlebitis

Rare (0.01% to 0.1%): Vasculitis

Very rare (less than 0.01%): Cardiac arrest

Frequency not reported: Bradycardia, cardiogenic shock, generalized flushing, hypotension, palpitations, substernal pressure, tachycardia

Postmarketing reports: Chest pain[Ref]

Hypotension, bradycardia, cardiogenic shock, and cardiac arrest have occurred with rapid bolus administration.[Ref]


Common (1% to 10%): Increased serum creatinine, increased serum urea, nephrotoxicity, renal insufficiency

Rare (0.01% to 0.1%): Acute renal failure, interstitial nephritis

Frequency not reported: Acute kidney injury, Acute tubular necrosis, azotemia, blood urea nitrogen (BUN) concentrations increased, uremia, transient increased urea[Ref]

Renal failure was most commonly characterized by increased serum creatinine levels or BUN concentrations.

Azotemia usually resolved upon discontinuation of treatment.[Ref]


Common (1% to 10%): Fatigue, mucosal inflammation, pyrexia

Uncommon (0.1% to 1%): Chills, fever, pain, permanent hearing loss, transient hearing loss

Rare (0.01% to 0.1%): Drug fever, ototoxicity, rigors, shivering, tinnitus[Ref]


Common (1% to 10%): Dyspnea, stridor

Frequency not reported: Wheezing[Ref]


Common (1% to 10%): Back pain

Rare (0.01% to 0.1%): Back and chest muscle pain and spasm[Ref]

Nervous system

Common (1% to 10%): Headache

Rare (0.01% to 0.1%): Dizziness, vertigo[Ref]


Common (1% to 10%): Urinary tract infection

Frequency not reported: Granular urinary casts[Ref]


Uncommon (0.1% to 1%): Eosinophilia,

Rare (0.01% to 0.1%): Agranulocytosis, leukopenia, pancytopenia, reversible agranulocytosis, reversible neutropenia, thrombocytopenia

Frequency not reported: Anemia[Ref]


Rare (0.01% to 0.1%): Anaphylactic reactions, anaphylaxis, hypersensitivity reactions

Frequency not reported: Anaphylactoid reaction[Ref]


Rare (0.01% to 0.1%): Superinfection

Frequency not reported: Drug rash with eosinophilia and systemic symptoms (DRESS), non-susceptible organism overgrowth[Ref]


Frequency not reported: Injection site inflammation, injection site pruritus, necrosis, tissue irritation[Ref]


Frequency not reported: Hemorrhagic occlusive retinal vasculitis (HORV), permanent vision loss[Ref]

HORV occurred in patients given this drug via intracameral or intravitreal route during/after cataract surgery.[Ref]


Frequency not reported: Depression, insomnia[Ref]


Frequency not reported: Transaminase elevations[Ref]

Frequently asked questions


1. Product Information. Vancocin (vancomycin). Lilly, Eli and Company. 2001;PROD.

2. Cerner Multum, Inc. UK Summary of Product Characteristics.

3. Cerner Multum, Inc. Australian Product Information.

4. Infectious Diseases Society of America. Position on Terminology for Vancomycin Flushing Reactions. 2021.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.