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Vancomycin Pregnancy and Breastfeeding Warnings

Vancomycin is also known as: Lyphocin, Vancocin, Vancocin HCl, Vancocin HCl Pulvules

Vancomycin Pregnancy Warnings

Vancomycin oral capsules have been assigned to category B by the FDA. The oral solution and parenteral formulation have been assigned to category C. Animal studies with intravenous administration of vancomycin at dosages 1 to 1.1 times the recommended human dose based on mg/m2 failed to reveal evidence of teratogenicity or fetotoxicity. The potential ototoxic and nephrotoxic effects of vancomycin on infants were evaluated in a limited, controlled study involving intravenous administration of vancomycin during the second and third trimester of pregnancy to women with serious staphylococcus infections. No sensorineural hearing loss or nephrotoxicity was attributed to the vancomycin therapy. Vancomycin is only recommended for use during pregnancy when benefit outweighs the risk.

Fetal harm could not be determined during this study. The number of patients treated was limited and vancomycin was administered only during the second and third trimesters.

See references

Vancomycin Breastfeeding Warnings

Vancomycin is excreted into human milk following intravenous administration. It is not known whether oral vancomycin is excreted in human milk. However, oral vancomycin is generally poorly absorbed and systemic concentrations are very low. The manufacturer recommends that due to the potential for serious adverse reactions in nursing infants, a decision should be made to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.

See references

References for pregnancy information

  1. "Product Information. Vancocin (vancomycin)." Lilly, Eli and Company, Indianapolis, IN.

References for breastfeeding information

  1. Reyes MP, Ostrea EM, Cabinian AE, Schmitt C, Rintelmann W "Vancomycin during pregnancy: does it cause hearing loss or nephrotoxicity in the infant?" Am J Obstet Gynecol 161 (1989): 977-81
  2. "Product Information. Vancocin (vancomycin)." Lilly, Eli and Company, Indianapolis, IN.

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