Umeclidinium Side Effects

Medically reviewed by Drugs.com. Last updated on Apr 2, 2025.

Applies to umeclidinium: inhalation powder.

Precautions

It is very important that your doctor check your progress at regular visits. This will allow your doctor to see if the medicine is working properly and to check for any unwanted effects.

Tell your doctor if you are also using any other medicine for your COPD. Your doctor may want you to use it only during a severe COPD attack. Follow your doctor's instructions on how you should take your medicine.

This medicine should not be used if you are having a severe COPD attack, or if symptoms of a COPD attack has already started. Your doctor may prescribe another medicine for you to use in case of an acute COPD attack. If the other medicine does not work as well, tell your doctor right away.

Talk with your doctor or get medical care right away if:

• Your symptoms do not improve after using this medicine for 1 week or if they become worse.
• Your short-acting inhaler does not seem to work as well as it used to and you need it more often than normal (eg, you use 1 whole canister of the short-acting inhaler in 8 weeks time, or you need to use 4 or more inhalations of the short-acting inhaler for 2 or more days in a row).
• You have a big decrease in your peak flow when measured as directed by your doctor.

This medicine should not be used together with atropine (eg, Atreza®) or similar inhaled medicines, such as aclidinium (eg, Tudorza® Pressair®), ipratropium (eg, Atrovent®, Atrovent® HFA), or tiotropium (eg, Spiriva®).

This medicine may cause paradoxical bronchospasm, which means your breathing or wheezing will get worse. Paradoxical bronchospasm may be life-threatening. Check with your doctor right away if you have coughing, difficulty breathing, shortness of breath, or wheezing after using this medicine.

This medicine may cause serious allergic reactions, including anaphylaxis and angioedema, which can be life-threatening and require immediate medical attention. Tell your doctor right away if you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth after using this medicine.

Check with your doctor right away if blurred vision, difficulty in reading, or any other change in vision occurs during or after treatment. Your doctor may want you to have your eyes checked by an ophthalmologist (eye doctor).

Check with your doctor right away if you have decrease in urine volume, decrease in the frequency of urination, difficulty in passing urine, or painful urination.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Serious side effects of umeclidinium

Along with its needed effects, umeclidinium may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking umeclidinium:

Other side effects of umeclidinium

Some side effects of umeclidinium may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to umeclidinium: inhalation powder.

Cardiovascular adverse events

• Common (1% to 10%): Tachycardia, hypertension, sinus tachycardia (greater than or equal to 1%)
• Uncommon (0.1% to 1%): Atrial fibrillation, idioventricular rhythm, supraventricular tachycardia, supraventricular extrasystoles^[Ref]

Dermatologic

• Common (1% to 10%): Rash^[Ref]

Gastrointestinal

• Common (1% to 10%): Upper abdominal pain, toothache, dyspepsia (greater or equal to 1%), diarrhea (greater or equal to 1%), nausea (greater or equal to 1%)
• Uncommon (0.1% to 1%): Constipation, dry mouth^[Ref]

Genitourinary

• Common (1% to 10%): Urinary tract infection
• Frequency not reported: Worsening of urinary retention^[Ref]

Musculoskeletal

• Common (1% to 10%): Arthralgia, myalgia, back pain, neck pain (greater or equal to 1%), pain in extremity (greater or equal to 1%)^[Ref]

Nervous system

• Common (1% to 10%): Headache, sinus headache (greater or equal to 1%), dizziness (greater or equal to 1%)
• Uncommon (0.1% to 1%): Dysgeusia^[Ref]

Other

• Common (1% to 10%): Contusion, vertigo (greater or equal to 1%)^[Ref]

Psychiatric

• Common (1% to 10%): Depression (greater or equal to 1%)^[Ref]

Respiratory

• Common (1% to 10%): Nasopharyngitis, upper respiratory tract infection, viral respiratory tract infection, cough, sinusitis, pneumonia (greater than or equal to 1%), lower respiratory tract infection (greater than or equal to 1%), rhinitis (greater than or equal to 1%), oropharyngeal pain (greater than or equal to 1%)
• Uncommon (0.1% to 1%): Pharyngitis^[Ref]

Ocular

• Frequency not reported: Worsening of narrow-angle glaucoma (eye pain or discomfort, blurred vision, visual halos or colored images in association with red eyes from conjunctival congestion and corneal edema)^[Ref]

See also:

Further information

Umeclidinium side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

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