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Trimethadione Side Effects

Medically reviewed by Drugs.com. Last updated on Aug 2, 2023.

Applies to trimethadione: oral capsule, oral tablet chewable.

Warning

You should not stop using trimethadione suddenly. Stopping suddenly may make your condition worse.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have:

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to trimethadione: oral capsule, oral tablet chewable.

Dermatologic

Frequency not reported: Acneiform or morbilliform skin rash that may progress to exfoliative dermatitis or to severe forms of erythema multiforme, lupus erythematosus and lymphadenopathies simulating malignant lymphoma, pruritus (associated with lymphadenopathy and hepatosplenomegaly)[Ref]

Gastrointestinal

Frequency not reported: Nausea, vomiting, abdominal pain, gastric distress, bleeding gums[Ref]

Genitourinary

Frequency not reported: Vaginal bleeding, albuminuria[Ref]

Hematologic

Frequency not reported: Neutropenia, leukopenia, eosinophilia, thrombocytopenia, pancytopenia, agranulocytosis, hypoplastic anemia, fatal aplastic anemia[Ref]

Hepatic

Rare (less than 0.1%): Hepatitis[Ref]

Musculoskeletal

Frequency not reported: Myasthenia gravis-like syndrome[Ref]

Nervous system

Frequency not reported: Drowsiness, fatigue, malaise, insomnia, vertigo, headache, paresthesias, precipitation of grand mal seizures, increased irritability[Ref]

Ocular

Frequency not reported: Hemeralopia, photophobia, diplopia, retinal and petechial hemorrhages[Ref]

Other

Frequency not reported: Hiccups, anorexia, weight loss, hair loss, changes in blood pressure, albuminuria[Ref]

Psychiatric

Frequency not reported: Personality changes[Ref]

Respiratory

Frequency not reported: Epistaxis[Ref]

More about trimethadione

Patient resources

Professional resources

Other brands

Tridione

Related treatment guides

References

1. Product Information. Tridione (trimethadione). Abbott Pharmaceutical. 2001.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.