Trimethadione Dosage
Applies to the following strengths: 300 mg; 150 mg
Usual Adult Dose for:
Usual Pediatric Dose for:
Additional dosage information:
Usual Adult Dose for Seizures
-Initial dose: 900 mg orally per day in equally divided doses 3 to 4 times a day; increase this dose by 300 mg at weekly intervals until therapeutic results are seen or until toxic symptoms appear
-Maintenance dose: 900 to 2400 mg orally per day in 3 or 4 equally divided doses (i.e., 300 to 600 mg orally 3 or 4 times a day
Comment:
-Maintenance dosage should be the least amount of drug required to maintain control.
Use: For the control of petit mal seizures that are refractory to treatment with other drugs
Usual Pediatric Dose for Seizures
300 to 900 mg orally per day in 3 or 4 equally divided doses
Use: For the control of petit mal seizures that are refractory to treatment with other drugs
Renal Dose Adjustments
Mild to moderate renal dysfunction: Frequent monitoring recommended.
Severe renal dysfunction: Use is not recommended.
Liver Dose Adjustments
Mild to moderate liver dysfunction: Frequent monitoring recommended.
Severe liver dysfunction: Use is not recommended.
Dose Adjustments
Ocular Dysfunction:
-A reduction in dosage may be necessary in the presence of hemeralopia.
-If scotomata develop therapy should be discontinued
Precautions
Consult WARNINGS section for additional precautions.
Dialysis
Data not available
Other Comments
General:
-This drug may cause serious side effects; therefore, patients should be monitored closely, especially during the first year of therapy.
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Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.