Trimethadione Dosage

Usual Adult Dose for Seizures

-Initial dose: 900 mg orally per day in equally divided doses 3 to 4 times a day; increase this dose by 300 mg at weekly intervals until therapeutic results are seen or until toxic symptoms appear
-Maintenance dose: 900 to 2400 mg orally per day in 3 or 4 equally divided doses (i.e., 300 to 600 mg orally 3 or 4 times a day

Comment:
-Maintenance dosage should be the least amount of drug required to maintain control.

Use: For the control of petit mal seizures that are refractory to treatment with other drugs

Usual Pediatric Dose for Seizures

300 to 900 mg orally per day in 3 or 4 equally divided doses

Use: For the control of petit mal seizures that are refractory to treatment with other drugs

Renal Dose Adjustments

Mild to moderate renal dysfunction: Frequent monitoring recommended.
Severe renal dysfunction: Use is not recommended.

Liver Dose Adjustments

Mild to moderate liver dysfunction: Frequent monitoring recommended.
Severe liver dysfunction: Use is not recommended.

Dose Adjustments

Ocular Dysfunction:
-A reduction in dosage may be necessary in the presence of hemeralopia.
-If scotomata develop therapy should be discontinued

Precautions

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

General:
-This drug may cause serious side effects; therefore, patients should be monitored closely, especially during the first year of therapy.