Trimethadione Dosage

Usual Adult Dose for Seizures

• Initial dose: 900 mg orally per day in equally divided doses 3 to 4 times a day; increase this dose by 300 mg at weekly intervals until therapeutic results are seen or until toxic symptoms appear
• Maintenance dose: 900 to 2400 mg orally per day in 3 or 4 equally divided doses (i.e., 300 to 600 mg orally 3 or 4 times a day

Comment:

• Maintenance dosage should be the least amount of drug required to maintain control.

Use: For the control of petit mal seizures that are refractory to treatment with other drugs

Usual Pediatric Dose for Seizures

300 to 900 mg orally per day in 3 or 4 equally divided doses

Use: For the control of petit mal seizures that are refractory to treatment with other drugs

Renal Dose Adjustments

Mild to moderate renal dysfunction: Frequent monitoring recommended.
Severe renal dysfunction: Use is not recommended.

Liver Dose Adjustments

Mild to moderate liver dysfunction: Frequent monitoring recommended.
Severe liver dysfunction: Use is not recommended.

Dose Adjustments

Ocular Dysfunction:

• A reduction in dosage may be necessary in the presence of hemeralopia.
• If scotomata develop therapy should be discontinued

Precautions

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

General:

• This drug may cause serious side effects; therefore, patients should be monitored closely, especially during the first year of therapy.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer