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Tridione Side Effects

Generic Name: trimethadione

Note: This page contains side effects data for the generic drug trimethadione. It is possible that some of the dosage forms included below may not apply to the brand name Tridione.

For the Consumer

Applies to trimethadione: oral tablet chewable

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have:

  • vision problems, droopy eyelids;

  • the first sign of any skin rash, no matter how mild;

  • unusual muscle weakness, trouble speaking or swallowing;

  • swelling in your feet or ankles;

  • low blood cell counts--fever, chills, flu-like symptoms, swollen gums, mouth sores, skin sores, rapid heart rate, pale skin, easy bruising, unusual bleeding, feeling light-headed;

  • lupus-like syndrome--joint pain or swelling with fever, swollen glands, muscle aches, chest pain, butterfly-shaped skin rash on your cheeks;

  • kidney problems--little or no urinating, painful or difficult urination, rapid weight gain;

  • liver problems--nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or

  • severe skin reaction--fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Common side effects may include:

  • nausea;

  • drowsiness;

  • changes in mood or behavior; or

  • increased seizures.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to trimethadione: oral capsule, oral tablet chewable

Dermatologic

Frequency not reported: Acneiform or morbilliform skin rash that may progress to exfoliative dermatitis or to severe forms of erythema multiforme, lupus erythematosus and lymphadenopathies simulating malignant lymphoma, pruritus (associated with lymphadenopathy and hepatosplenomegaly)[Ref]

Gastrointestinal

Frequency not reported: Nausea, vomiting, abdominal pain, gastric distress, bleeding gums[Ref]

Genitourinary

Frequency not reported: Vaginal bleeding, albuminuria[Ref]

Hematologic

Frequency not reported: Neutropenia, leukopenia, eosinophilia, thrombocytopenia, pancytopenia, agranulocytosis, hypoplastic anemia, fatal aplastic anemia[Ref]

Hepatic

Rare (less than 0.1%): Hepatitis[Ref]

Musculoskeletal

Frequency not reported: Myasthenia gravis-like syndrome[Ref]

Nervous system

Frequency not reported: Drowsiness, fatigue, malaise, insomnia, vertigo, headache, paresthesias, precipitation of grand mal seizures, increased irritability[Ref]

Ocular

Frequency not reported: Hemeralopia, photophobia, diplopia, retinal and petechial hemorrhages[Ref]

Other

Frequency not reported: Hiccups, anorexia, weight loss, hair loss, changes in blood pressure, albuminuria[Ref]

Psychiatric

Frequency not reported: Personality changes[Ref]

Respiratory

Frequency not reported: Epistaxis[Ref]

References

1. "Product Information. Tridione (trimethadione)" Abbott Pharmaceutical, Abbott Part, IL.

It is possible that some side effects of Tridione may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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