Skip to main content

Tridione Side Effects

Generic name: trimethadione

Medically reviewed by Last updated on Apr 11, 2022.

Note: This document contains side effect information about trimethadione. Some of the dosage forms listed on this page may not apply to the brand name Tridione.

Applies to trimethadione: oral capsule, oral tablet chewable


Frequency not reported: Acneiform or morbilliform skin rash that may progress to exfoliative dermatitis or to severe forms of erythema multiforme, lupus erythematosus and lymphadenopathies simulating malignant lymphoma, pruritus (associated with lymphadenopathy and hepatosplenomegaly)[Ref]


Frequency not reported: Nausea, vomiting, abdominal pain, gastric distress, bleeding gums[Ref]


Frequency not reported: Vaginal bleeding, albuminuria[Ref]


Frequency not reported: Neutropenia, leukopenia, eosinophilia, thrombocytopenia, pancytopenia, agranulocytosis, hypoplastic anemia, fatal aplastic anemia[Ref]


Rare (less than 0.1%): Hepatitis[Ref]


Frequency not reported: Myasthenia gravis-like syndrome[Ref]

Nervous system

Frequency not reported: Drowsiness, fatigue, malaise, insomnia, vertigo, headache, paresthesias, precipitation of grand mal seizures, increased irritability[Ref]


Frequency not reported: Hemeralopia, photophobia, diplopia, retinal and petechial hemorrhages[Ref]


Frequency not reported: Hiccups, anorexia, weight loss, hair loss, changes in blood pressure, albuminuria[Ref]


Frequency not reported: Personality changes[Ref]


Frequency not reported: Epistaxis[Ref]

More about Tridione (trimethadione)

Professional resources

Related treatment guides


1. "Product Information. Tridione (trimethadione)." Abbott Pharmaceutical (2001):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.