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Tranxene Side Effects

Generic Name: clorazepate

Note: This page contains side effects data for the generic drug clorazepate. It is possible that some of the dosage forms included below may not apply to the brand name Tranxene.

For the Consumer

Applies to clorazepate: oral capsule, oral tablet, oral tablet extended release

As well as its needed effects, clorazepate (the active ingredient contained in Tranxene) may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking clorazepate, check with your doctor immediately:

Less common:
  • Bladder pain
  • bloody or cloudy urine
  • difficult, burning, or painful urination
  • frequent urge to urinate
  • lower back or side pain
  • shakiness and unsteady walk
  • slurred speech
  • trembling or shaking of the hands or feet
  • unsteadiness, trembling, or other problems with muscle control or coordination

If any of the following symptoms of overdose occur while taking clorazepate, get emergency help immediately:

Symptoms of overdose:
  • Change in consciousness
  • drowsiness
  • loss of consciousness
  • relaxed and calm
  • sleepiness

Minor Side Effects

Some clorazepate side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Less common:
  • Blurred vision
  • diarrhea
  • discouragement
  • dizziness
  • double vision
  • dry mouth
  • feeling sad or empty
  • headache
  • indigestion
  • irritability
  • loss of appetite
  • loss of interest or pleasure
  • mental confusion
  • nausea or vomiting
  • nervousness
  • passing of gas
  • seeing double
  • skin rash
  • stomach pain, fullness, or discomfort
  • trouble with concentrating
  • trouble with sleeping
  • unusual tiredness or weakness

For Healthcare Professionals

Applies to clorazepate: oral tablet


The most commonly reported side effect was dizziness.


Frequency not reported: Insomnia, suicidal ideation/behavior, irritability, depression

Nervous system

Frequency not reported: Dizziness, nervousness, headache, mental confusion, tremor, slurred speech, ataxia[Ref]


Frequency not reported: Abnormal liver function tests


Frequency not reported: Abnormal kidney function tests


Frequency not reported: Decreased hematocrit


Frequency not reported: Fatigue[Ref]


Frequency not reported: Transient skin rash


Frequency not reported: Decrease in systolic blood pressure


Frequency not reported: Gastrointestinal complaints, dry mouth


Frequency not reported: Genitourinary complaints


Frequency not reported: Blurred vision, diplopia


1. "Product Information. Tranxene (clorazepate)." Abbott Pharmaceutical, Abbott Park, IL.

It is possible that some side effects of Tranxene may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.