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Terconazole topical Side Effects

Medically reviewed by Drugs.com. Last updated on Nov 15, 2023.

Applies to terconazole topical: vaginal cream, vaginal suppository.

Serious side effects of Terconazole topical

Along with its needed effects, terconazole topical may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking terconazole topical:

More common

Less common

Incidence not known

Other side effects of Terconazole topical

Some side effects of terconazole topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

Incidence not known

For Healthcare Professionals

Applies to terconazole topical: vaginal cream, vaginal suppository.

Nervous system

Headache was reported in 26%, 21%, and 30.3% of patients using the 0.4% vaginal cream, 0.8% vaginal cream, and vaginal suppositories, respectively. In clinical trials with the suppository, headache occurred in up to 20.7% of patients given placebo.[Ref]

Very common (10% or more): Headache (up to 30.3%)

Postmarketing reports: Dizziness[Ref]

Local

The suppository formulation was discontinued most often due to burning and pruritus.[Ref]

Frequency nor reported: Pain, rash

Vaginal suppositories:

-Very common (10% or more): Burning (15.2%)

-Common (1% to 10%): Pruritus[Ref]

Genitourinary

The cream formulations were discontinued most often due to vulvovaginal itching.[Ref]

Vaginal cream 0.4%:

-Frequency not reported: Vulvovaginal burning/itching/irritation

Vaginal cream 0.8%:

-Common (1% to 10%): Dysmenorrhea, genital burning and itching

-Frequency not reported: Vulvovaginal itching

Vaginal suppositories:

-Common (1% to 10%): Pain of the female genitalia[Ref]

Other

Frequency not reported: Influenza-like illness (consisting of fever, chills, nausea, dizziness)

Postmarketing reports: Asthenia, influenza-like illness (consisting of multiple reactions including fever, chills, nausea, vomiting, myalgia, arthralgia, malaise), face edema

Vaginal cream 0.4%

-Common (1% to 10%): Body pain, fever

-Uncommon (0.1% to 1%): Chills

Vaginal cream 0.8%

-Uncommon (0.1% to 1%): Fever

Vaginal suppositories

-Common (1% to 10%): Body pain, fever, chills[Ref]

Gastrointestinal

Vaginal cream 0.8%:

-Common (1% to 10%): Abdominal pain[Ref]

Hypersensitivity

Postmarketing reports: Hypersensitivity, anaphylaxis[Ref]

Dermatologic

Photosensitivity reactions were reported after repeated dermal application of 2% and 0.8% cream formulations under conditions of filtered artificial ultraviolet light. During US and foreign clinical trials, photosensitivity reactions were not reported in patients who were treated with the suppositories or vaginal cream (0.4% and 0.8%).[Ref]

Frequency not reported: Photosensitivity reactions

Postmarketing reports: Rash, toxic epidermal necrolysis, urticaria[Ref]

Respiratory

Frequency not reported: Dyspnea

Postmarketing reports: Bronchospasm[Ref]

At least 1 patient developed leukocytosis and dyspnea.[Ref]

Hematologic

At least 1 patient developed leukocytosis and dyspnea.[Ref]

Frequency not reported: Leukocytosis[Ref]

References

1. Product Information. Terazol 3 (terconazole topical). Apothecon Inc. 2022.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.