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Terazole 3 Side Effects

Generic name: terconazole topical

Medically reviewed by Drugs.com. Last updated on Jan 19, 2024.

Note: This document provides detailed information about Terazole 3 Side Effects associated with terconazole topical. Some dosage forms listed on this page may not apply specifically to the brand name Terazole 3.

Applies to terconazole topical: vaginal cream, vaginal suppository.

Serious side effects of Terazole 3

Along with its needed effects, terconazole topical (the active ingredient contained in Terazole 3) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking terconazole topical:

More common

  • burning feeling in the vagina

Less common

Incidence not known

  • blistering, peeling, or loosening of the skin
  • chills
  • cough
  • diarrhea
  • difficulty with swallowing
  • dizziness
  • fast heartbeat
  • fever
  • general feeling of discomfort or illness
  • headache
  • hives or welts
  • hoarseness
  • irritation
  • itching
  • joint or muscle pain
  • joint pain, stiffness or swelling
  • loss of appetite
  • muscle aches and pains
  • nausea
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • rash
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • redness of the skin
  • runny nose
  • shivering
  • skin rash
  • sore throat
  • sores, ulcers, or white spots in the mouth or on the lips
  • sweating
  • swelling of the eyelids, face, lips, hands, or feet
  • tightness in the chest
  • trouble sleeping
  • troubled breathing
  • unusual tiredness or weakness
  • vomiting

Other side effects of Terazole 3

Some side effects of terconazole topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • cramps
  • headache
  • heavy bleeding
  • pain

Less common

  • abdominal or stomach pain
  • body pain

Incidence not known

  • difficulty with moving
  • lack or loss of strength
  • muscle aching or cramping
  • muscle pain or stiffness
  • swollen joints

For healthcare professionals

Applies to terconazole topical: vaginal cream, vaginal suppository.

Nervous system

Headache was reported in 26%, 21%, and 30.3% of patients using the 0.4% vaginal cream, 0.8% vaginal cream, and vaginal suppositories, respectively. In clinical trials with the suppository, headache occurred in up to 20.7% of patients given placebo.[Ref]

Local

Vaginal suppositories:

Frequency nor reported: Pain, rash

The suppository formulation was discontinued most often due to burning and pruritus.[Ref]

Genitourinary

Vaginal cream 0.4%:

Vaginal cream 0.8%:

Vaginal suppositories:

The cream formulations were discontinued most often due to vulvovaginal itching.[Ref]

Other

Vaginal cream 0.4%

Vaginal cream 0.8%

Vaginal suppositories

Gastrointestinal

Vaginal cream 0.8%:

Hypersensitivity

Dermatologic

Photosensitivity reactions were reported after repeated dermal application of 2% and 0.8% cream formulations under conditions of filtered artificial ultraviolet light. During US and foreign clinical trials, photosensitivity reactions were not reported in patients who were treated with the suppositories or vaginal cream (0.4% and 0.8%).[Ref]

Respiratory

At least 1 patient developed leukocytosis and dyspnea.[Ref]

Hematologic

At least 1 patient developed leukocytosis and dyspnea.[Ref]

References

1. (2022) "Product Information. Terazol 3 (terconazole topical)." Apothecon Inc

More about Terazole 3 (terconazole topical)

Patient resources

Other brands

Terazol, Terazol 7, Zazole, Terazol 3

Professional resources

Other brands

Terazol 7

Related treatment guides

Further information

Terazole 3 side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.