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Suprane Side Effects

Generic name: desflurane

Medically reviewed by Drugs.com. Last updated on Mar 16, 2021.

Note: This document contains side effect information about desflurane. Some of the dosage forms listed on this page may not apply to the brand name Suprane.

In Summary

Common side effects of Suprane include: apnea, breath-holding, cough, and laryngospasm. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to desflurane: inhalation liquid, inhalation solution

Side effects requiring immediate medical attention

Along with its needed effects, desflurane (the active ingredient contained in Suprane) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking desflurane:

More common

  • Bluish lips or skin
  • body aches or pain
  • congestion
  • cough
  • dryness or soreness of the throat
  • fever
  • hoarseness
  • not breathing
  • runny nose
  • tender, swollen glands in the neck
  • tightness in the chest
  • trouble breathing
  • trouble swallowing
  • voice changes

Less common

  • Blurred vision
  • chest pain or discomfort
  • dizziness
  • fast, pounding, or irregular heartbeat or pulse
  • headache
  • lightheadedness, dizziness, or fainting
  • nervousness
  • pounding in the ears
  • slow or irregular heartbeat
  • unusual tiredness

Rare

  • Dark urine
  • difficulty with moving
  • feeling of warmth or heat
  • flushing or redness of the skin, especially on the face and neck
  • general tiredness and weakness
  • joint pain
  • light-colored stools
  • muscle aching or cramping
  • muscle pains or stiffness
  • nausea and vomiting
  • noisy breathing
  • pain or discomfort in the arms, jaw, back, or neck
  • sweating
  • swollen joints
  • upper right abdominal or stomach pain
  • yellow eyes and skin

Incidence not known

  • Abdominal or stomach pain
  • confusion
  • convulsions
  • decreased urine
  • dry mouth
  • increased thirst
  • loss of appetite
  • no blood pressure or pulse
  • numbness or tingling in the hands, feet, or lips
  • stopping of heart
  • unconsciousness
  • weakness or heaviness of the legs

Side effects not requiring immediate medical attention

Some side effects of desflurane may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Increased watering of the mouth
  • redness of the white part of the eyes or inside of the eyelids

Rare

  • Anxiety
  • hyperventilation
  • irritability
  • itching skin
  • restlessness
  • shaking
  • trouble sleeping

For Healthcare Professionals

Applies to desflurane: inhalation liquid

Respiratory

Very common (10% or more): Breath holding (27% in adults; 68% in pediatrics), laryngospasm (50% in pediatrics), cough (34%), apnea (15%)

Common (1% to 10%): Pharyngitis, apnea, cough, laryngospasm

Uncommon (0.1% to 1%): Hypoxia

Frequency not reported: Respiratory arrest, respiratory failure, respiratory distress, bronchospasm, hemoptysis[Ref]

Gastrointestinal

Very common (10% or more): Nausea (27%), salivary hypersecretion (21%), vomiting

Frequency not reported: Acute pancreatitis, abdominal pain[Ref]

Cardiovascular

Common (1% to 10%): Nodal arrhythmia, bradycardia, tachycardia, hypertension

Uncommon (0.1% to 1%): Myocardial infarction, myocardial ischemia, arrhythmia, vasodilation, ECG abnormal, electrocardiogram ST-T change, electrocardiogram T wave inversion

Frequency not reported: Cardiac arrest, torsade de pointes, ventricular failure, ventricular hypokinesia, malignant hypertension, hemorrhage, hypotension, shock, tachyarrhythmia, palpitations[Ref]

Nervous system

Common (1% to 10%): Headache

Uncommon (0.1% to 1%): Dizziness

Frequency not reported: Seizures, encephalopathy[Ref]

Hepatic

Frequency not reported: Hepatic necrosis, cytolytic hepatitis, cholestasis, jaundice, hepatic function abnormal, liver disorder, alanine aminotransferase increased, aspartate aminotransferase increased[Ref]

Ocular

Common (1% to 10%): Conjunctivitis

Frequency not reported: Ocular icterus, eye burns, transient blindness, ulcerative keratitis, ocular hyperemia, reduced visual acuity, eye irritation, eye pain[Ref]

Metabolic

Frequency not reported: Hyperkalemia, hypokalemia, metabolic acidosis, ammonia increased[Ref]

Musculoskeletal

Uncommon (0.1% to 1%): Myalgia

Frequency not reported: Rhabdomyolysis[Ref]

Dermatologic

Frequency not reported: Urticaria, erythema, skin burning sensation[Ref]

Hematologic

Frequency not reported: Coagulopathy, coagulation test abnormal[Ref]

Psychiatric

Uncommon (0.1% to 1%): Agitation[Ref]

Other

Common (1% to 10%): Increased creatinine phosphokinase

Frequency not reported: Malignant hyperthermia, asthenia, malaise, migraine, fatigue[Ref]

References

1. "Product Information. Suprane (desflurane)." Baxter Pharmaceutical Products, Inc, New Providence, NJ.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.