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Desflurane use while Breastfeeding

Drugs containing Desflurane: Suprane

Desflurane Levels and Effects while Breastfeeding

Summary of Use during Lactation

There is no published experience with desflurane during breastfeeding. Because the serum half-life of desflurane in the mother is short and the drug is not expected to be absorbed by the infant, no waiting period or discarding of milk is required. Breastfeeding can be resumed as soon as the mother has recovered sufficiently from general anesthesia to nurse.[1] When a combination of anesthetic agents is used for a procedure, follow the recommendations for the most problematic medication used during the procedure. In one study, breastfeeding before general anesthesia induction reduced requirements of sevoflurane and propofol compared to those of nursing mothers whose breastfeeding was withheld or nonnursing women.[2] It is possible that requirements for other anesthetic agents would be affected similarly.

Drug Levels

The serum half-life of desflurane is less than 3 minutes, so extensive passage into milk is unlikely.

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

Alternate Drugs to Consider

Enflurane, Isoflurane, Sevoflurane

References

1. Dalal PG, Bosak J, Berlin C. Safety of the breast-feeding infant after maternal anesthesia. Paediatr Anaesth. 2014;24:359-71. PMID: 24372776

2. Bhaskara B, Dayananda VP, Kannan S et al. Effect of breastfeeding on haemodynamics and consumption of propofol and sevoflurane: A state entropy guided comparative study. Indian J Anaesth. 2016;60:180-6. PMID: 27053781

Desflurane Identification

Substance Name

Desflurane

CAS Registry Number

57041-67-5

Drug Class

Anesthetics, Inhalation

Administrative Information

LactMed Record Number

611

Last Revision Date

20160426

Disclaimer

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