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Desflurane Dosage

Applies to the following strengths: 100%

Usual Adult Dose for:

Usual Geriatric Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Anesthesia

The administration of general anesthesia must be individualized based on the patient's response.

Inhalation: The minimum alveolar concentration (MAC), the concentration at which 50% of patients do not respond to surgical incision, ranges from 7.3% (25 years of age) to 6.0% (45 years of age). The concentration at which amnesia and loss of awareness occur (MAC - awake) is 2.4%. Surgical levels of anesthesia are achieved with concentrations between 2.5% and 8.5%.

Usual Geriatric Dose for Anesthesia

The administration of general anesthesia must be individualized based on the patient's response.

MAC is reduced (5.2% at 70 years of age).

Usual Pediatric Dose for Anesthesia

The administration of general anesthesia must be individualized based on the patient's response.

Surgical levels of anesthesia range between 5.2% to 10%.

Renal Dose Adjustments

No adjustment recommended

Liver Dose Adjustments

No adjustment recommended

Dose Adjustments

In patients with intracranial space occupying lesions desflurane should be administered at 0.8 MAC or less, in conjunction with a barbiturate induction and hyperventilation (hypocapnia). Appropriate measures should be taken to maintain cerebral perfusion pressure.

Dialysis

Data not available

Other Comments

Because of the higher vapor pressure of desflurane, its vaporizer is heated in order to deliver a constant concentration.

Desflurane should be delivered from a vaporizer specifically designed and designated for use with desflurane.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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