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Sipuleucel-T Side Effects

Medically reviewed by Drugs.com. Last updated on Apr 8, 2023.

Applies to sipuleucel-T: intravenous suspension.

Serious side effects of Sipuleucel-T

Along with its needed effects, sipuleucel-T may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking sipuleucel-T:

More common

Other side effects of Sipuleucel-T

Some side effects of sipuleucel-T may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

For Healthcare Professionals

Applies to sipuleucel-T: intravenous suspension.

Other

Very common (10% or more): Acute infusion reactions (71.2%), chills (53.1%), fatigue (41.1%), fever (31.3%)

Common (1% to 10%): Influenza-like illness, peripheral edema, hot flush

Cardiovascular

Common (1% to 10%): Hypertension

Uncommon (0.1% to 1%): Myocardial infarction

Postmarketing reports: Hypotension, thromboembolic events (deep vein thrombosis and pulmonary embolism)[Ref]

Musculoskeletal

Very common (10% or more): Back pain (29.6%), joint ache (19.6%), extremity pain (12.1%)

Common (1% to 10%): Musculoskeletal pain, muscle spasms, bone pain, musculoskeletal chest pain, neck pain[Ref]

Gastrointestinal

Very common (10% or more): Nausea (21.5%), vomiting (13.3%), constipation (12.3%), oral paresthesia (12.3%), diarrhea (10%)[Ref]

Nervous system

Very common (10% or more): Headache (18.1%), paresthesia (14.1%), dizziness (11.8%), muscle ache (11.8%), asthenia (10.8%)

Common (1% to 10%): Insomnia, tremor, cerebrovascular events (hemorrhagic and ischemic strokes)

Postmarketing reports: Transient ischemic attack, syncope[Ref]

Metabolic

Very common (10% or more): Citrate toxicity (14.8%)

Common (1% to 10%): Anorexia, decreased weight

Hematologic

Very common (10% or more): Anemia (12.5%)

Common (1% to 10%): Hematuria[Ref]

Respiratory

Common (1% to 10%): Dyspnea, upper respiratory tract infection, cough[Ref]

Genitourinary

Common (1% to 10%): Urinary tract infection[Ref]

Dermatologic

Common (1% to 10%): Rash, sweating[Ref]

References

1. Product Information. Provenge (sipuleucel-T). Dendreon Corporation. 2022.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.