Salsalate Side Effects

Medically reviewed by Drugs.com. Last updated on Nov 20, 2023.

Applies to salsalate: oral tablets.

Important warnings This medicine can cause some serious health issues

Cardiovascular Risk
• Possible increased risk of serious (sometimes fatal) cardiovascular thrombotic events (e.g., MI, stroke).^b Risk may increase with duration of use.^b Individuals with cardiovascular disease or risk factors for cardiovascular disease may be at increased risk.^b (See Cardiovascular Effects under Cautions.)

• Contraindicated for the treatment of pain in the setting of CABG surgery.^b

GI Risk
• Increased risk of serious (sometimes fatal) GI events (e.g., bleeding, ulceration, perforation of the stomach or intestine).^b Serious GI events can occur at any time and may not be preceded by warning signs and symptoms.^b Geriatric individuals are at greater risk for serious GI events.^b (See GI Effects under Cautions.)

Side effects include:

Tinnitus, nausea, hearing impairment, rash, vertigo.

For healthcare professionals

Applies to salsalate: oral capsule, oral tablet.

General

The most frequently reported side effects were usually reversible and included tinnitus, nausea, hearing impairment, rash, and vertigo.^[Ref]

Gastrointestinal

• Frequency not reported: Nausea, abdominal pain, diarrhea, gastrointestinal bleeding^[Ref]

Cardiovascular

• Frequency not reported: Hypotension^[Ref]

Dermatologic

• Frequency not reported: Rash, angioedema, urticaria^[Ref]

Hepatic

• Frequency not reported: Hepatic function abnormal, hepatitis^[Ref]

Renal

• Frequency not reported: Nephritis^[Ref]

Respiratory

• Frequency not reported: Bronchospasm^[Ref]

Other

• Frequency not reported: Tinnitus, hearing impaired, vertigo, creatinine clearance decreased^[Ref]

Immunologic

• Frequency not reported: Anaphylactic shock^[Ref]

Further information

Salsalate side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer