Revefenacin Side Effects

Medically reviewed by Drugs.com. Last updated on Mar 5, 2025.

Applies to revefenacin: inhalation solution.

Precautions

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly and to check for unwanted effects.

Tell your doctor if you are also using other medicines for your COPD. Your doctor may want you to stop using the other medicine and use it only during a severe COPD attack. Follow your doctor's instructions on how you should take your medicine.

This medicine should not be used if you are having a severe COPD attack, or if symptoms of COPD attack have already started. Your doctor may prescribe another medicine for you to use in case of an acute COPD attack. If the other medicine does not work as well, tell your doctor right away.

Talk to your doctor or get medical care right away if your symptoms do not improve after using this medicine within a few days or if they become worse, or your short-acting inhaler does not seem to be working as well as usual and you need to use it more often.

This medicine may cause paradoxical bronchospasm, which means your breathing or wheezing will get worse. Paradoxical bronchospasm may be life-threatening. Check with your doctor right away if you are having a cough, difficulty with breathing, shortness of breath, or wheezing after using this medicine.

If you develop a skin rash, hives, swelling of the tongue, lips, or face, or any allergic reaction to this medicine, check with your doctor right away.

Check with your doctor right away if blurred vision, difficulty in reading, seeing halos around lights, or any other change in vision occurs during or after treatment. Your doctor may want you to have your eyes checked by an ophthalmologist (eye doctor).

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Serious side effects of revefenacin

Along with its needed effects, revefenacin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking revefenacin:

Get emergency help immediately if any of the following symptoms of overdose occur while taking revefenacin:

Symptoms of overdose

• change in vision
• eye pain or redness
• loss of vision
• nausea
• severe constipation
• vomiting

Other side effects of revefenacin

Some side effects of revefenacin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to revefenacin: inhalation solution.

Hypersensitivity adverse events

• Frequency not reported: Immediate hypersensitivity^[Ref]

Respiratory

• Common (1% to 10%): Cough, oropharyngeal pain
• Frequency not reported: Paradoxical bronchospasm^[Ref]

Cardiovascular

• Common (1% to 10%): Hypertension^[Ref]

Immunologic

• Common (1% to 10%): Nasopharyngitis, upper respiratory tract infection, bronchitis^[Ref]

Ocular

• Frequency not reported: Worsening of narrow angle glaucoma^[Ref]

Nervous system

• Common (1% to 10%): Headache, dizziness^[Ref]

Genitourinary

• Frequency not reported: Worsening of urinary retention^[Ref]

Musculoskeletal

• Common (1% to 10%): Back pain^[Ref]

See also:

Frequently asked questions

• How do you use Yupelri inhalation solution?

Further information

Revefenacin side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer